[Term]
id: PR:000000128
name: smad4
def: "A smad protein that is a translation product of the human SMAD4 gene or a 1:1 ortholog thereof. It lacks the C-terminal SSxS motif, necessary for receptor mediated phosphorylation, that is present in the receptor-regulated smads." [PMID:10708949, PRO:CNA]
comment: Category=gene.
synonym: "DPC4" RELATED Gene-based []
synonym: "MADH4" RELATED Gene-based []
synonym: "SMAD4" EXACT PRO-short-label [PRO:DNx]
synonym: "SMAD 4" EXACT []
synonym: "MAD homolog 4" EXACT []
synonym: "SMAD family member 4" EXACT []
synonym: "mothers against DPP homolog 4" EXACT []
synonym: "deletion target in pancreatic carcinoma 4" EXACT []
synonym: "deletion target in pancreatic carcinoma 4 homolog" EXACT []
xref: PIRSF:PIRSF500408
is_a: PR:000000027 ! smad protein

[Term]
id: PR:000025958
name: mothers against decapentaplegic homolog 4 isoform 1 monoubiquitinated 2 (human)
def: "A smad4 isoform 1 monoubiquitinated 2 in human. UniProtKB:Q13485-1, Lys-519, MOD:01148." [PMID:19135894]
comment: Category=organism-modification.
synonym: "hSMAD4/iso:1/MonoUbiq:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q13485-1, Lys-519, MOD:01148" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000025957 ! smad4 isoform 1 monoubiquitinated 2
relationship: has_part MOD:01148 ! ubiquitinylated lysine

[Term]
id: PR:000025956
name: mothers against decapentaplegic homolog 4 isoform 1 monoubiquitinated 1 (human)
def: "A smad4 isoform 1 monoubiquitinated 1 in human. UniProtKB:Q13485-1, Lys-507, MOD:01148." [PMID:18783722]
comment: Category=organism-modification.
synonym: "hSMAD4/iso:1/MonoUbiq:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q13485-1, Lys-507, MOD:01148" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000025955 ! smad4 isoform 1 monoubiquitinated 1
relationship: has_part MOD:01148 ! ubiquitinylated lysine

[Term]
id: PR:000049288
name: mothers against decapentaplegic homolog 4 ADP-ribosylated form (human)
def: "A mothers against decapentaplegic homolog 4 (human) that includes at least one ADP-ribosylated residue. UniProtKB:Q13485, MOD:00752." [PRO:DNx, Reactome:R-HSA-2187323]
comment: Category=organism-modification.
synonym: "hSMAD4/ADPribRes+" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q13485, MOD:00752" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-2187323 "PR:000049288 located_in GO:0005654"
intersection_of: has_part MOD:00752 ! adenosine diphosphoribosyl (ADP-ribosyl) modified residue
intersection_of: PR:Q13485 ! mothers against decapentaplegic homolog 4 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000045915
name: mothers against decapentaplegic homolog 4 phosphorylated 1 (human)
def: "A mothers against decapentaplegic homolog 4 (human) that has been phosphorylated at Thr-77. UniProtKB:Q13485, Thr-77, MOD:00047." [PMID:20974850, iPTMnet:Q13485]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:20974850). Status=unreviewed.
synonym: "hSMAD4/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q13485, Thr-77, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:Q13485 ! mothers against decapentaplegic homolog 4 (human)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000036483
name: mothers against decapentaplegic homolog 4 isoform 1 phosphorylated 1 (human)
def: "A smad4 isoform 1 phosphorylated 1 in human. UniProtKB:Q13485-1, Thr-277, MOD:00047." [PMID:12801888, PRO:CNA]
comment: Category=organism-modification.
synonym: "hSMAD4/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q13485-1, Thr-277, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000579 ! smad4 isoform 1 phosphorylated 1
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:Q13485
name: mothers against decapentaplegic homolog 4 (human)
def: "A smad4 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q13485]
comment: Category=organism-gene.
synonym: "DPC4" RELATED Gene-based [UniProtKB:Q13485]
synonym: "MADH4" RELATED Gene-based [UniProtKB:Q13485]
synonym: "SMAD4" RELATED Gene-based [UniProtKB:Q13485]
synonym: "hSMAD4" EXACT PRO-short-label [PRO:DNx]
synonym: "Smad4 (human)" EXACT [UniProtKB:Q13485]
synonym: "SMAD 4 (human)" EXACT [UniProtKB:Q13485]
synonym: "MAD homolog 4 (human)" EXACT [UniProtKB:Q13485]
synonym: "SMAD family member 4 (human)" EXACT [UniProtKB:Q13485]
synonym: "mothers against DPP homolog 4 (human)" EXACT [UniProtKB:Q13485]
synonym: "deletion target in pancreatic carcinoma 4 (human)" EXACT [UniProtKB:Q13485]
xref: Reactome:R-HSA-177103 "PR:Q13485 located_in GO:0005654"
xref: Reactome:R-HSA-170862 "PR:Q13485 located_in GO:0005829"
xref: UniProtKB:Q13485
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000128 ! smad4
relationship: has_gene_template HGNC:6770 ! SMAD4 (human)

[Term]
id: PR:Q13485-1
name: mothers against decapentaplegic homolog 4 isoform 1 (human)
def: "A smad4 isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hSMAD4/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q13485-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000366 ! smad4 isoform 1