[Term]
id: PR:000036477
name: Rho-associated protein kinase 2 isoform 1 cleaved 1 (human)
def: "A Rho-associated protein kinase 2 isoform 1 cleaved 1 in human. UniProtKB:O75116-1, 1-1131." [PMID:15699075, PRO:CNA]
comment: Category=organism-modification.
synonym: "hROCK2/iso:1/Clv:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O75116-1, 1-1131" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000564 ! Rho-associated protein kinase 2 isoform 1 cleaved 1

[Term]
id: PR:000000566
name: Rho-associated protein kinase 2 isoform 1 phosphorylated 2
def: "A Rho-associated protein kinase 2 isoform 1 phosphorylated form that has been induced by DNA damage. Example: UniProtKB:O75116-1, Thr-1078, MOD:00047." [PMID:17525332, PRO:CNA, PRO:DAN]
comment: Category=modification.
synonym: "ROCK2/iso:1/Phos:2" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000462 ! Rho-associated protein kinase 2 isoform 1 phosphorylated form
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:000000565
name: Rho-associated protein kinase 2 isoform 1 phosphorylated 1
def: "A Rho-associated protein kinase 2 isoform 1 phosphorylated form in which the phosphorylation occurs within the C-terminal region by the action of serine/threonine-protein kinase PLK1." [PMID:17446864]
comment: Category=modification. Note: Phosphorylation can occur at Ser and/or Thr residues.
synonym: "ROCK2/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000462 ! Rho-associated protein kinase 2 isoform 1 phosphorylated form
relationship: has_part MOD:00696 ! phosphorylated residue

[Term]
id: PR:000000564
name: Rho-associated protein kinase 2 isoform 1 cleaved 1
def: "A Rho-associated protein kinase 2 isoform 1 that has been cleaved in the granzyme B consensus motif [IVL][GE]xD located between the Rho binding and the PH domains, removing the C-terminus." [PRO:CNA]
comment: Category=modification. Note: This form has constitutive kinase activity.
synonym: "ROCK2/iso:1/Clv:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000308 ! Rho-associated protein kinase 2 isoform 1
relationship: output_of GO:0016485 ! protein processing

[Term]
id: PR:O75116
name: Rho-associated protein kinase 2 (human)
def: "A Rho-associated protein kinase 2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:O75116]
comment: Category=organism-gene.
synonym: "ROCK2" RELATED Gene-based [UniProtKB:O75116]
synonym: "hROCK2" EXACT PRO-short-label [PRO:DNx]
synonym: "KIAA0619" RELATED Gene-based [UniProtKB:O75116]
synonym: "ROCK-II (human)" EXACT [UniProtKB:O75116]
synonym: "p164 ROCK-2 (human)" EXACT [UniProtKB:O75116]
synonym: "Rho kinase 2 (human)" EXACT [UniProtKB:O75116]
synonym: "Rho-associated, coiled-coil-containing protein kinase 2 (human)" EXACT [UniProtKB:O75116]
synonym: "Rho-associated, coiled-coil-containing protein kinase II (human)" EXACT [UniProtKB:O75116]
xref: Reactome:R-HSA-419058 "PR:O75116 located_in GO:0005829"
xref: Reactome:R-HSA-4687775 "PR:O75116 located_in GO:0005829"
xref: DTO:03100457
xref: UniProtKB:O75116
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000121 ! Rho-associated protein kinase 2
relationship: has_gene_template HGNC:10252 ! ROCK2 (human)

[Term]
id: PR:P70336-1
name: Rho-associated protein kinase 2 isoform 1 (mouse)
def: "A Rho-associated protein kinase 2 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mROCK2/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P70336-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000308 ! Rho-associated protein kinase 2 isoform 1

[Term]
id: PR:000000121
name: Rho-associated protein kinase 2
def: "A Rho-associated protein kinase that is a translation product of the human ROCK2 gene or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=gene.
synonym: "ROCK2" EXACT PRO-short-label [PRO:DNx]
synonym: "ROCK-II" EXACT []
synonym: "KIAA0619" RELATED Gene-based []
synonym: "p164 ROCK-2" EXACT []
synonym: "rho kinase 2" EXACT []
synonym: "rho-associated, coiled-coil-containing protein kinase 2" EXACT []
synonym: "Rho-associated, coiled-coil-containing protein kinase II" EXACT []
xref: IUPHARobj:1504
is_a: PR:000000024 ! Rho-associated protein kinase

[Term]
id: PR:000002530
name: Rho-associated protein kinase 2 isoform 1 unmodified form
def: "A Rho-associated protein kinase 2 isoform 1 that has not been subjected to any co- or post-translational residue modification or peptide bond cleavage." [PRO:DNx]
comment: Category=modification.
synonym: "ROCK2/iso:1/UnMod" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000000308 ! Rho-associated protein kinase 2 isoform 1
intersection_of: has_part PR:000021935 ! immature protein part
intersection_of: lacks_part PR:000025513 ! modified amino-acid residue
disjoint_from: PR:000018264 ! proteolytic cleavage product

[Term]
id: PR:O75116-1
name: Rho-associated protein kinase 2 isoform 1 (human)
def: "A Rho-associated protein kinase 2 isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hROCK2/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O75116-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000308 ! Rho-associated protein kinase 2 isoform 1

[Term]
id: PR:Q62868
name: Rho-associated protein kinase 2 (rat)
def: "A Rho-associated protein kinase 2 that is encoded in the genome of rat." [OMA:Q62868, PANTHER:PTHR22988:SF3, PRO:DNx]
comment: Category=organism-gene.
synonym: "Rock2" RELATED Gene-based [UniProtKB:Q62868]
synonym: "rROCK2" EXACT PRO-short-label [PRO:DNx]
synonym: "ROCK-II (rat)" EXACT [UniProtKB:Q62868]
synonym: "ROKalpha (rat)" EXACT [UniProtKB:Q62868]
synonym: "p164 ROCK-2 (rat)" EXACT [UniProtKB:Q62868]
synonym: "p150 ROK-alpha (rat)" EXACT [UniProtKB:Q62868]
synonym: "RhoA-binding kinase 2 (rat)" EXACT [UniProtKB:Q62868]
synonym: "Rho-associated, coiled-coil-containing protein kinase 2 (rat)" EXACT [UniProtKB:Q62868]
synonym: "Rho-associated, coiled-coil-containing protein kinase II (rat)" EXACT [UniProtKB:Q62868]
xref: UniProtKB:Q62868
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000000121 ! Rho-associated protein kinase 2
relationship: has_gene_template RGD:3590 ! Rock2 (rat)

[Term]
id: PR:000036478
name: Rho-associated protein kinase 2 isoform 1 phosphorylated 1 (human)
def: "A Rho-associated protein kinase 2 isoform 1 phosphorylated 1 in human. UniProtKB:O75116-1, Ser-1134/Ser-1137, MOD:00046." [PMID:15302935, PMID:17446864, PRO:CNA]
comment: Category=organism-modification.
synonym: "hROCK2/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O75116-1, Ser-1134/Ser-1137, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:000000565 ! Rho-associated protein kinase 2 isoform 1 phosphorylated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000036479
name: Rho-associated protein kinase 2 isoform 1 phosphorylated 2 (human)
def: "A Rho-associated protein kinase 2 isoform 1 phosphorylated 2 in human. UniProtKB:O75116-1, Thr-1078, MOD:00047." [PMID:17525332, PRO:CNA]
comment: Category=organism-modification.
synonym: "hROCK2/iso:1/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O75116-1, Thr-1078, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000566 ! Rho-associated protein kinase 2 isoform 1 phosphorylated 2
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:P70336
name: Rho-associated protein kinase 2 (mouse)
def: "A Rho-associated protein kinase 2 that is encoded in the genome of mouse." [OMA:P70336, PRO:DNx]
comment: Category=organism-gene.
synonym: "Rock2" RELATED Gene-based [UniProtKB:P70336]
synonym: "mROCK2" EXACT PRO-short-label [PRO:DNx]
synonym: "ROCK-II (mouse)" EXACT [UniProtKB:P70336]
synonym: "p164 ROCK-2 (mouse)" EXACT [UniProtKB:P70336]
synonym: "Rho-associated, coiled-coil-containing protein kinase 2 (mouse)" EXACT [UniProtKB:P70336]
synonym: "Rho-associated, coiled-coil-containing protein kinase II (mouse)" EXACT [UniProtKB:P70336]
xref: UniProtKB:P70336
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000121 ! Rho-associated protein kinase 2
relationship: has_gene_template MGI:107926 ! Rock2 (mouse)

[Term]
id: PR:P70336-2
name: Rho-associated protein kinase 2 isoform 2 (mouse)
def: "A Rho-associated protein kinase 2 isoform 2 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mROCK2/iso:2" EXACT PRO-short-label [PRO:DNx]
synonym: "rho-associated protein kinase 2 isoform ROCK2m (mouse)" EXACT [UniProtKB:P70336]
xref: UniProtKB:P70336-2
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000309 ! Rho-associated protein kinase 2 isoform 2

[Term]
id: PR:000000309
name: Rho-associated protein kinase 2 isoform 2
def: "A Rho-associated protein kinase 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P70336-2 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
comment: Category=sequence.
synonym: "ROCK2M" RELATED []
synonym: "ROCK2/iso:2" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000121 ! Rho-associated protein kinase 2

[Term]
id: PR:000000308
name: Rho-associated protein kinase 2 isoform 1
def: "A Rho-associated protein kinase 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75116-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
comment: Category=sequence. Note: In resting cells, the C-terminal Rho-binding and PH domain mask the protein kinase catalytic domain, activation occurs through a conformational change.
synonym: "ROCK2/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000121 ! Rho-associated protein kinase 2

[Term]
id: PR:000000462
name: Rho-associated protein kinase 2 isoform 1 phosphorylated form
def: "A Rho-associated protein kinase 2 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]
comment: Category=modification.
synonym: "ROCK2/iso:1/PhosRes+" EXACT PRO-short-label [PRO:DNx]
intersection_of: has_part MOD:00696 ! phosphorylated residue
intersection_of: PR:000000308 ! Rho-associated protein kinase 2 isoform 1

[Term]
id: PR:000025436
name: Rho-associated protein kinase 2 proteolytic cleavage product
def: "A Rho-associated protein kinase 2 that has been processed by proteolytic cleavage." [PRO:DNx]
comment: Category=modification.
synonym: "ROCK2/ClvPrd" EXACT PRO-short-label [PRO:DNx]
intersection_of: output_of GO:0016485 ! protein processing
intersection_of: PR:000000121 ! Rho-associated protein kinase 2