[Term]
id: PR:O75116
name: Rho-associated protein kinase 2 (human)
def: "A Rho-associated protein kinase 2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:O75116]
comment: Category=organism-gene.
synonym: "ROCK2" RELATED Gene-based [UniProtKB:O75116]
synonym: "hROCK2" EXACT PRO-short-label [PRO:DNx]
synonym: "KIAA0619" RELATED Gene-based [UniProtKB:O75116]
synonym: "ROCK-II (human)" EXACT [UniProtKB:O75116]
synonym: "p164 ROCK-2 (human)" EXACT [UniProtKB:O75116]
synonym: "Rho kinase 2 (human)" EXACT [UniProtKB:O75116]
synonym: "Rho-associated, coiled-coil-containing protein kinase 2 (human)" EXACT [UniProtKB:O75116]
synonym: "Rho-associated, coiled-coil-containing protein kinase II (human)" EXACT [UniProtKB:O75116]
xref: Reactome:R-HSA-419058 "PR:O75116 located_in GO:0005829"
xref: Reactome:R-HSA-4687775 "PR:O75116 located_in GO:0005829"
xref: DTO:03100457
xref: UniProtKB:O75116
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000121 ! Rho-associated protein kinase 2
relationship: has_gene_template HGNC:10252 ! ROCK2 (human)

[Term]
id: PR:000000121
name: Rho-associated protein kinase 2
def: "A Rho-associated protein kinase that is a translation product of the human ROCK2 gene or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=gene.
synonym: "ROCK2" EXACT PRO-short-label [PRO:DNx]
synonym: "ROCK-II" EXACT []
synonym: "KIAA0619" RELATED Gene-based []
synonym: "p164 ROCK-2" EXACT []
synonym: "rho kinase 2" EXACT []
synonym: "rho-associated, coiled-coil-containing protein kinase 2" EXACT []
synonym: "Rho-associated, coiled-coil-containing protein kinase II" EXACT []
xref: IUPHARobj:1504
is_a: PR:000000024 ! Rho-associated protein kinase

[Term]
id: PR:O75116-1
name: Rho-associated protein kinase 2 isoform 1 (human)
def: "A Rho-associated protein kinase 2 isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hROCK2/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O75116-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000308 ! Rho-associated protein kinase 2 isoform 1

[Term]
id: PR:000036478
name: Rho-associated protein kinase 2 isoform 1 phosphorylated 1 (human)
def: "A Rho-associated protein kinase 2 isoform 1 phosphorylated 1 in human. UniProtKB:O75116-1, Ser-1134/Ser-1137, MOD:00046." [PMID:15302935, PMID:17446864, PRO:CNA]
comment: Category=organism-modification.
synonym: "hROCK2/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O75116-1, Ser-1134/Ser-1137, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:000000565 ! Rho-associated protein kinase 2 isoform 1 phosphorylated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000036479
name: Rho-associated protein kinase 2 isoform 1 phosphorylated 2 (human)
def: "A Rho-associated protein kinase 2 isoform 1 phosphorylated 2 in human. UniProtKB:O75116-1, Thr-1078, MOD:00047." [PMID:17525332, PRO:CNA]
comment: Category=organism-modification.
synonym: "hROCK2/iso:1/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O75116-1, Thr-1078, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000566 ! Rho-associated protein kinase 2 isoform 1 phosphorylated 2
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:000036477
name: Rho-associated protein kinase 2 isoform 1 cleaved 1 (human)
def: "A Rho-associated protein kinase 2 isoform 1 cleaved 1 in human. UniProtKB:O75116-1, 1-1131." [PMID:15699075, PRO:CNA]
comment: Category=organism-modification.
synonym: "hROCK2/iso:1/Clv:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O75116-1, 1-1131" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000564 ! Rho-associated protein kinase 2 isoform 1 cleaved 1