[Term]
id: PR:000000103
name: mitogen-activated protein kinase 1
def: "A mitogen-activated protein kinase that is a translation product of the human MAPK1 gene or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=gene.
synonym: "ERK2" RELATED Gene-based []
synonym: "ERT1" EXACT []
synonym: "Mapk" RELATED Gene-based []
synonym: "ERK-2" EXACT []
synonym: "MAPK1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRKM1" RELATED Gene-based []
synonym: "PRKM2" RELATED Gene-based []
synonym: "MAPK 1" EXACT []
synonym: "MAPK 2" EXACT []
synonym: "p42-MAPK" EXACT []
synonym: "MAP kinase 1" EXACT []
synonym: "MAP kinase 2" EXACT []
synonym: "MAP kinase isoform p42" EXACT []
synonym: "mitogen-activated protein kinase 2" EXACT []
synonym: "extracellular signal-regulated kinase 2" EXACT []
xref: IUPHARobj:1495
is_a: PR:000000019 ! mitogen-activated protein kinase

[Term]
id: PR:000026341
name: mitogen-activated protein kinase 1 isoform 1 phosphorylated 1 (human)
def: "A mitogen-activated protein kinase 1 isoform 1 phosphorylated 1 in human. UniProtKB:P28482-1, Thr-185, MOD:00047|Tyr-187, MOD:00048." [PRO:DNx, UniProtKB:P28482]
comment: Category=organism-modification.
synonym: "hMAPK1/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P28482-1, Thr-185, MOD:00047|Tyr-187, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000556 ! mitogen-activated protein kinase 1 isoform 1 phosphorylated 1
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine

[Term]
id: PR:P28482
name: mitogen-activated protein kinase 1 (human)
def: "A mitogen-activated protein kinase 1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P28482]
comment: Category=organism-gene.
synonym: "ERK2" RELATED Gene-based [UniProtKB:P28482]
synonym: "MAPK1" RELATED Gene-based [UniProtKB:P28482]
synonym: "PRKM1" RELATED Gene-based [UniProtKB:P28482]
synonym: "PRKM2" RELATED Gene-based [UniProtKB:P28482]
synonym: "hMAPK1" EXACT PRO-short-label [PRO:DNx]
synonym: "ERT1 (human)" EXACT [UniProtKB:P28482]
synonym: "ERK-2 (human)" EXACT [UniProtKB:P28482]
synonym: "MAPK 1 (human)" EXACT [UniProtKB:P28482]
synonym: "MAPK 2 (human)" EXACT [UniProtKB:P28482]
synonym: "p42-MAPK (human)" EXACT [UniProtKB:P28482]
synonym: "MAP kinase 1 (human)" EXACT [UniProtKB:P28482]
synonym: "MAP kinase 2 (human)" EXACT [UniProtKB:P28482]
synonym: "MAP kinase isoform p42 (human)" EXACT [UniProtKB:P28482]
synonym: "mitogen-activated protein kinase 2 (human)" EXACT [UniProtKB:P28482]
synonym: "extracellular signal-regulated kinase 2 (human)" EXACT [UniProtKB:P28482]
xref: DTO:03100315
xref: UniProtKB:P28482
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000103 ! mitogen-activated protein kinase 1
relationship: has_gene_template HGNC:6871 ! MAPK1 (human)

[Term]
id: PR:P28482-1
name: mitogen-activated protein kinase 1 isoform 1 (human)
def: "A mitogen-activated protein kinase 1 isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence. Requested by=PubChem.
synonym: "hMAPK1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P28482-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000289 ! mitogen-activated protein kinase 1 isoform 1

[Term]
id: PR:P28482-2
name: mitogen-activated protein kinase 1 isoform h2 (human)
def: "A mitogen-activated protein kinase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P28482-2." [PRO:DNx, UniProtKB:P28482]
comment: Category=organism-sequence.
synonym: "hMAPK1/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P28482-2
is_a: PR:P28482 ! mitogen-activated protein kinase 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000048314
name: mitogen-activated protein kinase 1, initiator methionine removed phosphorylated 1 (human)
def: "A mitogen-activated protein kinase 1 (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 185, and phosphotyrosine at position 187 of the amino acid sequence represented by UniProtKB:P28482. UniProtKB:P28482, 2-360, Thr-185, MOD:00047|Tyr-187, MOD:00048." [PRO:DNx, Reactome:R-HSA-109853, Reactome:R-HSA-112354]
comment: Category=organism-modification.
synonym: "hMAPK1/InitMet-/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000186247, Thr-185, MOD:00047|Tyr-187, MOD:00048" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P28482, 2-360, Thr-185, MOD:00047|Tyr-187, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-109853 "PR:000048314 located_in GO:0005829"
xref: Reactome:R-HSA-112354 "PR:000048314 located_in GO:0005654"
is_a: PR:P28482 ! mitogen-activated protein kinase 1 (human)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000045734
name: mitogen-activated protein kinase 1 phosphorylated 1 (human)
def: "A mitogen-activated protein kinase 1 (human) that has been phosphorylated at the position equivalent to Ser-29 of the amino acid sequence represented by UniProtKB:P28482-1. Example: UniProtKB:P28482-1, Ser-29, MOD:00046." [PMID:19447520, iPTMnet:P28482]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:19447520). Status=unreviewed.
synonym: "hMAPK1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P28482-1, Ser-29, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P28482 ! mitogen-activated protein kinase 1 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000048313
name: mitogen-activated protein kinase 1, initiator methionine removed form (human)
def: "A mitogen-activated protein kinase 1 (human) that has had the initiator methionine removed. UniProtKB:P28482, 2-360." [PRO:DNx, Reactome:R-HSA-199960, Reactome:R-HSA-59282]
comment: Category=organism-modification.
synonym: "PRO_0000186247" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hMAPK1/InitMet-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P28482, 2-360" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-59282 "PR:000048313 located_in GO:0005829"
xref: Reactome:R-HSA-199960 "PR:000048313 located_in GO:0005654"
xref: Reactome:R-HSA-6799225 "PR:000048313 located_in GO:0035578"
xref: Reactome:R-HSA-6800964 "PR:000048313 located_in GO:1904813"
xref: Reactome:R-HSA-6806250 "PR:000048313 located_in GO:0005576"
xref: Reactome:R-HSA-9636293 "PR:000048313 located_in GO:0005788"
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:P28482 ! mitogen-activated protein kinase 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens