[Term]
id: PR:000000093
name: cyclin-dependent kinase 4 inhibitor B
def: "A cyclin-dependent kinase inhibitor that is a translation product of the human CDKN2B gene or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=gene.
synonym: "MTS2" RELATED Gene-based []
synonym: "MTS-2" EXACT []
synonym: "CDKN2B" EXACT PRO-short-label [PRO:DNx]
synonym: "p15INK4B" EXACT []
synonym: "p14-INK4b" EXACT []
synonym: "p15-INK4b" EXACT []
synonym: "multiple tumor suppressor 2" EXACT []
xref: PANTHER:PTHR24144:SF138
is_a: PR:000000014 ! cyclin-dependent kinase inhibitor

[Term]
id: PR:000000428
name: cyclin-dependent kinase 4 inhibitor B isoform 1 phosphorylated form
def: "A cyclin-dependent kinase 4 inhibitor B isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]
comment: Category=modification.
synonym: "CDKN2B/iso:1/PhosRes+" EXACT PRO-short-label [PRO:DNx]
intersection_of: has_part MOD:00696 ! phosphorylated residue
intersection_of: PR:000000268 ! cyclin-dependent kinase 4 inhibitor B isoform 1

[Term]
id: PR:P42772-2
name: cyclin-dependent kinase 4 inhibitor B isoform h2 (human)
def: "A cyclin-dependent kinase 4 inhibitor B (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P42772-2." [PRO:DNx, UniProtKB:P42772]
comment: Category=organism-sequence.
synonym: "hCDKN2B/iso:h2" EXACT PRO-short-label [PRO:DNx]
synonym: "cyclin-dependent kinase 4 inhibitor B isoform p10 (human)" EXACT [UniProtKB:P42772]
xref: UniProtKB:P42772-2
is_a: PR:P42772 ! cyclin-dependent kinase 4 inhibitor B (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P42772-1
name: cyclin-dependent kinase 4 inhibitor B isoform 1 (human)
def: "A cyclin-dependent kinase 4 inhibitor B isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hCDKN2B/iso:1" EXACT PRO-short-label [PRO:DNx]
synonym: "cyclin-dependent kinase 4 inhibitor B isoform p15 (human)" EXACT [UniProtKB:P42772]
xref: UniProtKB:P42772-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000268 ! cyclin-dependent kinase 4 inhibitor B isoform 1

[Term]
id: PR:P55272-2
name: cyclin-dependent kinase 4 inhibitor B isoform Short (rat)
def: "A cyclin-dependent kinase 4 inhibitor B (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P55272-2." [PRO:DNx, UniProtKB:P55272]
comment: Category=organism-sequence.
synonym: "rCDKN2B/iso:Short" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P55272-2
is_a: PR:P55272 ! cyclin-dependent kinase 4 inhibitor B (rat)
relationship: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus

[Term]
id: PR:P55272-1
name: cyclin-dependent kinase 4 inhibitor B isoform Long (rat)
def: "A cyclin-dependent kinase 4 inhibitor B (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P55272-1." [PRO:DNx, UniProtKB:P55272]
comment: Category=organism-sequence.
synonym: "rCDKN2B/iso:Long" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P55272-1
is_a: PR:P55272 ! cyclin-dependent kinase 4 inhibitor B (rat)
relationship: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus

[Term]
id: PR:P42772
name: cyclin-dependent kinase 4 inhibitor B (human)
def: "A cyclin-dependent kinase 4 inhibitor B that is encoded in the genome of human." [PRO:CNA, UniProtKB:P42772]
comment: Category=organism-gene.
synonym: "MTS2" RELATED Gene-based [UniProtKB:P42772]
synonym: "CDKN2B" RELATED Gene-based [UniProtKB:P42772]
synonym: "hCDKN2B" EXACT PRO-short-label [PRO:DNx]
synonym: "MTS-2 (human)" EXACT [UniProtKB:P42772]
synonym: "p15INK4B (human)" EXACT [UniProtKB:P42772]
synonym: "p14-INK4b (human)" EXACT [UniProtKB:P42772]
synonym: "p15-INK4b (human)" EXACT [UniProtKB:P42772]
synonym: "multiple tumor suppressor 2 (human)" EXACT [UniProtKB:P42772]
xref: Reactome:R-HSA-182586 "PR:P42772 located_in GO:0005829"
xref: UniProtKB:P42772
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000093 ! cyclin-dependent kinase 4 inhibitor B
relationship: has_gene_template HGNC:1788 ! CDKN2B (human)

[Term]
id: PR:000000270
name: cyclin-dependent kinase 4 inhibitor B sequence variant A50V (human)
def: "A cyclin-dependent kinase 4 inhibitor B (human) that has a Val residue at the position equivalent to Ala-50 of the amino acid sequence represented by UniProtKB:P42772-1. Example: UniProtKB:P42772-1, Ala-50, CHEBI:30015." [PMID:7882351, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence. Note: This variant is implicated in lung adenocarcinoma.
synonym: "hCDKN2B/var:A50V" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P42772-1, Ala-50, CHEBI:30015" NARROW PRO-proteoform-std [PRO:DAN]
synonym: "cyclin-dependent kinase 4 inhibitor B sequence variant 2 (human)" EXACT [PRO:DNx]
xref: UniProtKB_VAR:VAR_001489
is_a: PR:P42772 ! cyclin-dependent kinase 4 inhibitor B (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P55271
name: cyclin-dependent kinase 4 inhibitor B (mouse)
def: "A cyclin-dependent kinase 4 inhibitor B that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-gene.
synonym: "Cdkn2b" RELATED Gene-based [UniProtKB:P55271]
synonym: "mCDKN2B" EXACT PRO-short-label [PRO:DNx]
synonym: "p14-INK4b (mouse)" EXACT [UniProtKB:P55271]
synonym: "p15-INK4b (mouse)" EXACT [UniProtKB:P55271]
xref: UniProtKB:P55271
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000093 ! cyclin-dependent kinase 4 inhibitor B
relationship: has_gene_template MGI:104737 ! Cdkn2b (mouse)

[Term]
id: PR:P55272
name: cyclin-dependent kinase 4 inhibitor B (rat)
def: "A cyclin-dependent kinase 4 inhibitor B that is encoded in the genome of rat." [PANTHER:PTHR24144:SF138, PRO:DNx]
comment: Category=organism-gene.
synonym: "Ink4" RELATED Gene-based [UniProtKB:P55272]
synonym: "Cdkn2b" RELATED Gene-based [UniProtKB:P55272]
synonym: "rCDKN2B" EXACT PRO-short-label [PRO:DNx]
synonym: "p14-INK4b (rat)" EXACT [UniProtKB:P55272]
synonym: "p15-INK4b (rat)" EXACT [UniProtKB:P55272]
xref: UniProtKB:P55272
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000000093 ! cyclin-dependent kinase 4 inhibitor B
relationship: has_gene_template RGD:2324 ! Cdkn2b (rat)

[Term]
id: PR:000000268
name: cyclin-dependent kinase 4 inhibitor B isoform 1
def: "A cyclin-dependent kinase 4 inhibitor B that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P42772-1 or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=sequence.
synonym: "CDKN2B/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000093 ! cyclin-dependent kinase 4 inhibitor B

[Term]
id: PR:000000269
name: cyclin-dependent kinase 4 inhibitor B sequence variant G47E (human)
def: "A cyclin-dependent kinase 4 inhibitor B (human) that has a Glu residue at the position equivalent to Gly-47 of the amino acid sequence represented by UniProtKB:P42772-1. Example: UniProtKB:P42772-1, Gly-47, CHEBI:29972." [PMID:7882351, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence. Note: This variant is implicated in lung adenocarcinoma.
synonym: "hCDKN2B/var:G47E" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P42772-1, Gly-47, CHEBI:29972" NARROW PRO-proteoform-std [PRO:DAN]
synonym: "cyclin-dependent kinase 4 inhibitor B sequence variant 1 (human)" EXACT [PRO:DNx]
xref: UniProtKB_VAR:VAR_001488
is_a: PR:P42772 ! cyclin-dependent kinase 4 inhibitor B (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000000543
name: cyclin-dependent kinase 4 inhibitor B isoform 1 phosphorylated 1
def: "A cyclin-dependent kinase 4 inhibitor B isoform 1 phosphorylated form in which the phosphorylation occurs on a residue equivalent to Thr-12 of the amino acid sequence represented by UniProtKB:P55271-1. Example: UniProtKB:P55271-1, Thr-12, MOD:00047." [UniProtKB:P55271]
comment: Category=modification.
synonym: "CDKN2B/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000428 ! cyclin-dependent kinase 4 inhibitor B isoform 1 phosphorylated form
relationship: has_part MOD:00047 ! O-phospho-L-threonine

[Term]
id: PR:000036455
name: cyclin-dependent kinase 4 inhibitor B isoform 1 phosphorylated 1 (mouse)
def: "A cyclin-dependent kinase 4 inhibitor B isoform 1 phosphorylated 1 in mouse. UniProtKB:P55271-1, Thr-12, MOD:00047." [PMID:15345747, PRO:CNA]
comment: Category=organism-modification.
synonym: "mCDKN2B/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P55271-1, Thr-12, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000543 ! cyclin-dependent kinase 4 inhibitor B isoform 1 phosphorylated 1
relationship: has_part MOD:00047 ! O-phospho-L-threonine