[Term]
id: PR:O13790
name: cullin-1 (Schizosaccharomyces pombe 972h-)
def: "A fungal/metazoan cullin-1 that is encoded in the genome of Schizosaccharomyces pombe 972h-." [OMA:O13790, PRO:DNx]
comment: Category=organism-gene.
synonym: "cul1" RELATED Gene-based [UniProtKB:O13790]
synonym: "pcu1" RELATED Gene-based [UniProtKB:O13790]
synonym: "SPAC17G6.12" RELATED Gene-based [UniProtKB:O13790]
synonym: "Spom972h-CUL1" EXACT PRO-short-label [PRO:DNx]
synonym: "Cul-1 (Schizosaccharomyces pombe 972h-)" EXACT [UniProtKB:O13790]
synonym: "cell division control 53 homolog (Schizosaccharomyces pombe 972h-)" EXACT [UniProtKB:O13790]
xref: UniProtKB:O13790
intersection_of: only_in_taxon NCBITaxon:284812 ! Schizosaccharomyces pombe 972h-
intersection_of: PR:000000092 ! fungal/metazoan cullin-1
relationship: has_gene_template PomBase:SPAC17G6.12 ! cul1 (Schizosaccharomyces pombe)

[Term]
id: PR:000000092
name: fungal/metazoan cullin-1
def: "A cullin that is a translation product of the human CUL1 gene or a 1:1 ortholog thereof in fungi or metazoa." [PRO:CNA]
comment: Category=gene.
synonym: "CUL1" EXACT PRO-short-label [PRO:DNx]
synonym: "CUL-1" EXACT []
xref: PANTHER:PTHR11932:SF19
is_a: PR:000000013 ! cullin
relationship: only_in_taxon NCBITaxon:33154 ! Opisthokonta

[Term]
id: PR:Q24311
name: cullin homolog 1 (fruit fly)
def: "A fungal/metazoan cullin-1 that is encoded in the genome of fruit fly." [OMA:Q24311, PRO:DNx]
comment: Category=organism-gene.
synonym: "Cul1" RELATED Gene-based [UniProtKB:Q24311]
synonym: "cul-1" RELATED Gene-based [UniProtKB:Q24311]
synonym: "lin19" RELATED Gene-based [UniProtKB:Q24311]
synonym: "CG1877" RELATED Gene-based [UniProtKB:Q24311]
synonym: "fly-CUL1" EXACT PRO-short-label [PRO:DNx]
synonym: "lin-19 homolog protein (fruit fly)" EXACT [UniProtKB:Q24311]
xref: UniProtKB:Q24311
intersection_of: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster
intersection_of: PR:000000092 ! fungal/metazoan cullin-1
relationship: has_gene_template FlyBase:FBgn0015509 ! Cul1 (fruit fly)

[Term]
id: PR:O60999
name: cullin-1 (Dictyostelium discoideum)
def: "A fungal/metazoan cullin-1 that is encoded in the genome of Dictyostelium discoideum." [OMA:O60999, PRO:DNx]
comment: Category=organism-gene.
synonym: "cul1" RELATED Gene-based [UniProtKB:O60999]
synonym: "culA" RELATED Gene-based [UniProtKB:O60999]
synonym: "Dicty-CUL1" EXACT PRO-short-label [PRO:DNx]
synonym: "DDB_G0291972" RELATED Gene-based [UniProtKB:O60999]
synonym: "CUL-1 (Dictyostelium discoideum)" EXACT [UniProtKB:O60999]
synonym: "cullin-A (Dictyostelium discoideum)" EXACT [UniProtKB:O60999]
xref: UniProtKB:O60999
intersection_of: only_in_taxon NCBITaxon:44689 ! Dictyostelium discoideum
intersection_of: PR:000000092 ! fungal/metazoan cullin-1
relationship: has_gene_template dictyBase:DDB_G0291972 ! culA (Dictyostelium discoideum)

[Term]
id: PR:Q13616-1
name: cullin-1 isoform 1 (human)
def: "A fungal/metazoan cullin-1 isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hCUL1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q13616-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000267 ! fungal/metazoan cullin-1 isoform 1

[Term]
id: PR:Q12018
name: cell division control protein 53 (yeast)
def: "A fungal/metazoan cullin-1 that is encoded in the genome of yeast." [OMA:Q12018, PRO:DNx]
comment: Category=organism-gene.
synonym: "CDC53" RELATED Gene-based [UniProtKB:Q12018]
synonym: "D2190" RELATED Gene-based [UniProtKB:Q12018]
synonym: "yCUL1" EXACT PRO-short-label [PRO:DNx]
synonym: "YDL132W" RELATED Gene-based [UniProtKB:Q12018]
synonym: "cullin-A (yeast)" EXACT [UniProtKB:Q12018]
synonym: "E3 ubiquitin ligase complex SCF subunit CDC53 (yeast)" EXACT [UniProtKB:Q12018]
xref: UniProtKB:Q12018
intersection_of: only_in_taxon NCBITaxon:559292 ! Saccharomyces cerevisiae S288C
intersection_of: PR:000000092 ! fungal/metazoan cullin-1
relationship: has_gene_template SGD:S000002290 ! CDC53 (yeast)

[Term]
id: PR:000000427
name: fungal/metazoan cullin-1 isoform 1 neddylated form
def: "A fungal/metazoan cullin-1 isoform 1 that includes at least one neddylated lysine." [PRO:CNA]
comment: Category=modification.
synonym: "CUL1/iso:1/NeddLys+" EXACT PRO-short-label [PRO:DNx]
intersection_of: has_part MOD:01150 ! neddylated lysine
intersection_of: PR:000000267 ! fungal/metazoan cullin-1 isoform 1
relationship: only_in_taxon NCBITaxon:33154 ! Opisthokonta

[Term]
id: PR:Q9WTX6
name: cullin-1 (mouse)
def: "A fungal/metazoan cullin-1 that is encoded in the genome of mouse." [OMA:Q9WTX6, PRO:DNx]
comment: Category=organism-gene.
synonym: "Cul1" RELATED Gene-based [UniProtKB:Q9WTX6]
synonym: "mCUL1" EXACT PRO-short-label [PRO:DNx]
synonym: "CUL-1 (mouse)" EXACT [UniProtKB:Q9WTX6]
xref: UniProtKB:Q9WTX6
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000092 ! fungal/metazoan cullin-1
relationship: has_gene_template MGI:1349658 ! Cul1 (mouse)

[Term]
id: PR:000000267
name: fungal/metazoan cullin-1 isoform 1
def: "A fungal/metazoan cullin-1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13616-1 or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=sequence.
synonym: "CUL1/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000092 ! fungal/metazoan cullin-1
relationship: only_in_taxon NCBITaxon:33154 ! Opisthokonta

[Term]
id: PR:Q9WTX6-1
name: cullin-1 isoform 1 (mouse)
def: "A fungal/metazoan cullin-1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mCUL1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9WTX6-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000267 ! fungal/metazoan cullin-1 isoform 1

[Term]
id: PR:000000542
name: fungal/metazoan cullin-1 isoform 1 neddylated 1
def: "A fungal/metazoan cullin-1 isoform 1 neddylated form that has been neddylated in the conserved Lys residue within the IVR[ILV]MKxR[RK] motif. Example: UniProtKB:Q13616-1, Lys-720, MOD:01150." [PMID:10713156]
comment: Category=modification.
synonym: "CUL1/iso:1/Nedd:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000427 ! fungal/metazoan cullin-1 isoform 1 neddylated form
relationship: has_part MOD:01150 ! neddylated lysine
relationship: only_in_taxon NCBITaxon:33154 ! Opisthokonta

[Term]
id: PR:Q17389
name: cullin-1 (worm)
def: "A fungal/metazoan cullin-1 that is encoded in the genome of worm." [OMA:Q17389, PRO:DNx]
comment: Category=organism-gene.
synonym: "cul-1" RELATED Gene-based [UniProtKB:Q17389]
synonym: "lin-19" RELATED Gene-based [UniProtKB:Q17389]
synonym: "D2045.6" RELATED Gene-based [UniProtKB:Q17389]
synonym: "CUL1 (worm)" EXACT PRO-short-label [PRO:DNx]
synonym: "CUL-1 (worm)" EXACT [UniProtKB:Q17389]
synonym: "abnormal cell lineage protein 19 (worm)" EXACT [UniProtKB:Q17389]
xref: UniProtKB:Q17389
intersection_of: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans
intersection_of: PR:000000092 ! fungal/metazoan cullin-1
relationship: has_gene_template WormBase:WBGene00000836 ! cul-1 (worm)

[Term]
id: PR:Q13616
name: cullin-1 (human)
def: "A fungal/metazoan cullin-1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-gene.
synonym: "CUL1" RELATED Gene-based [UniProtKB:Q13616]
synonym: "hCUL1" EXACT PRO-short-label [PRO:DNx]
synonym: "CUL-1 (human)" EXACT [UniProtKB:Q13616]
xref: Reactome:R-HSA-174230 "PR:Q13616 located_in GO:0005829"
xref: Reactome:R-HSA-187551 "PR:Q13616 located_in GO:0005654"
xref: UniProtKB:Q13616
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000092 ! fungal/metazoan cullin-1
relationship: has_gene_template HGNC:2551 ! CUL1 (human)

[Term]
id: PR:000036454
name: cullin-1 isoform 1 neddylated 1 (human)
def: "A fungal/metazoan cullin-1 isoform 1 neddylated 1 in human. UniProtKB:Q13616-1, Lys-720, MOD:01150." [PMID:10713156, PMID:10921923, PMID:17098746, PMID:8681378, PRO:CNA]
comment: Category=organism-modification.
synonym: "hCUL1/iso:1/Nedd:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q13616-1, Lys-720, MOD:01150" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000542 ! fungal/metazoan cullin-1 isoform 1 neddylated 1
relationship: has_part MOD:01150 ! neddylated lysine