[Term]
id: PR:Q13705
name: activin receptor type-2B (human)
def: "An activin receptor type-2B that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q13705]
comment: Category=organism-gene.
synonym: "ACVR2B" RELATED Gene-based [UniProtKB:Q13705]
synonym: "hACVR2B" EXACT PRO-short-label [PRO:DNx]
synonym: "ACTR-IIB (human)" EXACT [UniProtKB:Q13705]
synonym: "activin receptor type IIB (human)" EXACT [UniProtKB:Q13705]
xref: DTO:03100039
xref: UniProtKB:Q13705
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000071 ! activin receptor type-2B
relationship: has_gene_template HGNC:174 ! ACVR2B (human)

[Term]
id: PR:000000071
name: activin receptor type-2B
def: "A TGF-beta superfamily receptor type-2 with activin receptor domain that is a translation product of the human ACVR2B gene or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=gene.
synonym: "ACVR2B" EXACT PRO-short-label [PRO:DNx]
synonym: "ACTR-IIB" EXACT []
synonym: "activin receptor type IIB" EXACT []
xref: IUPHARobj:1792
xref: PIRSF:PIRSF500456
is_a: PR:000000007 ! TGF-beta superfamily receptor type-2 with activin receptor domain

[Term]
id: PR:000000215
name: activin receptor type-2B sequence variant V494I (human)
def: "An activin receptor type-2B (human) that has an Ile residue at the position equivalent to Val-494 of the amino acid sequence represented by UniProtKB:Q13705-1. Example: UniProtKB:Q13705-1, Val-494, CHEBI:30009." [PMID:9916847, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hACVR2B/var:V494I" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q13705-1, Val-494, CHEBI:30009" NARROW PRO-proteoform-std [PRO:DAN]
synonym: "activin receptor type-2B sequence variant 2 (human)" EXACT [PRO:DNx]
xref: UniProtKB_VAR:VAR_013282
is_a: PR:Q13705 ! activin receptor type-2B (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000000214
name: activin receptor type-2B sequence variant R40H (human)
def: "An activin receptor type-2B (human) that has a His residue at the position equivalent to Arg-40 of the amino acid sequence represented by UniProtKB:Q13705-1. This variation is within the extracellular domain. Example: UniProtKB:Q13705-1, Arg-40, CHEBI:29979." [PMID:9916847, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hACVR2B/var:R40H" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q13705-1, Arg-40, CHEBI:29979" NARROW PRO-proteoform-std [PRO:DAN]
synonym: "activin receptor type-2B sequence variant 1 (human)" EXACT [PRO:DNx]
xref: UniProtKB_VAR:VAR_013281
is_a: PR:Q13705 ! activin receptor type-2B (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000036443
name: activin receptor type-2B isoform ActR-IIB2 N-glycosylated and phosphorylated 1 (human)
def: "An activin receptor type-2B isoform ActR-IIB2 N-glycosylated and phosphorylated 1 in human." [PMID:11279102, PMID:24337809, PMID:8161782, PMID:8622651, PMID:9872992, PRO:CNA, PRO:DAN]
comment: Category=organism-modification.
synonym: "hACVR2B/iso:1/GlycoPhos:1" EXACT [PRO:DNx]
synonym: "hACVR2B/iso:ActR-IIB2/NGlycoPhos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "activin receptor type-2B isoform 1 glycosylated and phosphorylated 1 (human)" EXACT [PRO:CNA]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000529 ! activin receptor type-2B isoform ActR-IIB2 N-glycosylated and phosphorylated 1
relationship: has_part MOD:00006 ! N-glycosylated residue
relationship: has_part MOD:00696 ! phosphorylated residue

[Term]
id: PR:Q13705-1
name: activin receptor type-2B isoform ActR-IIB2 (human)
def: "An activin receptor type-2B isoform ActR-IIB2 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hACVR2B/iso:ActR-IIB2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q13705-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000209 ! activin receptor type-2B isoform ActR-IIB2

[Term]
id: PR:000046259
name: activin receptor type-2B, signal peptide removed form (human)
def: "An activin receptor type-2B (human) that has had the signal peptide removed. UniProtKB:Q13705, 19-512." [PRO:DNx, Reactome:R-HSA-201656]
comment: Category=organism-modification.
synonym: "PRO_0000024404" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hACVR2B/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q13705, 19-512" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-201656 "PR:000046259 located_in GO:0005886"
intersection_of: PR:Q13705 ! activin receptor type-2B (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q13705-2
name: activin receptor type-2B isoform ActR-IIBtrunc (human)
def: "An activin receptor type-2B isoform ActR-IIBtrunc that is encoded in the genome of human." [PMID:9916847, PRO:DNx, UniProtKB:Q13705]
comment: Category=organism-sequence.
synonym: "hACVR2B/iso:ActR-IIB1" EXACT PRO-short-label [PRO:DNx]
synonym: "activin receptor type-2B isoform ActR-IIB1 (human)" EXACT [UniProtKB:Q13705]
xref: UniProtKB:Q13705-2
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000210 ! activin receptor type-2B isoform ActR-IIBtrunc