[Term]
id: PR:Q13873
name: bone morphogenetic protein receptor type-2 (human)
def: "A BMP receptor type-2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q13873]
comment: Category=organism-gene.
synonym: "PPH1" RELATED Gene-based [UniProtKB:Q13873]
synonym: "BMPR2" RELATED Gene-based [UniProtKB:Q13873]
synonym: "hBMPR2" EXACT PRO-short-label [PRO:DNx]
synonym: "BMPR-2 (human)" EXACT [UniProtKB:Q13873]
synonym: "BMPR-II (human)" EXACT [UniProtKB:Q13873]
synonym: "BMP type-2 receptor (human)" EXACT [UniProtKB:Q13873]
synonym: "BMP type II receptor (human)" EXACT [UniProtKB:Q13873]
synonym: "bone morphogenetic protein receptor type II (human)" EXACT [UniProtKB:Q13873]
xref: DTO:03100043
xref: UniProtKB:Q13873
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000037 ! BMP receptor type-2
relationship: has_gene_template HGNC:1078 ! BMPR2 (human)

[Term]
id: PR:000057061
name: bone morphogenetic protein receptor type-2 N-glycosylated 1 (human)
def: "A bone morphogenetic protein receptor type-2 (human) that has been N-glycosylated at the residue equivalent to Asn-827 of the amino acid sequence represented by UniProtKB:Q13873-1, in which the glycan composition is represented by GlyTouCan:G10486CT. Example: UniProtKB:Q13873-1, Asn-827, MOD:00160~GNO:G10486CT." [GlyGen:Q13873-1, PMID:29671580, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hBMPR2/NGlyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q13873-1, Asn-827, MOD:00160~GNO:G10486CT" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:Q13873 ! bone morphogenetic protein receptor type-2 (human)
relationship: has_part GNO:G10486CT ! G10486CT
relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000000149
name: BMP receptor type-2 sequence variant C60Y (human)
def: "A bone morphogenetic protein receptor type-2 (human) that has a Tyr residue at the position equivalent to Cys-60 of the amino acid sequence represented by UniProtKB:Q13873-1. Example: UniProtKB:Q13873-1, Cys-60, CHEBI:46858." [PMID:11015450, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hBMPR2/var:C60Y" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q13873-1, Cys-60, CHEBI:46858" NARROW PRO-proteoform-std [PRO:DAN]
synonym: "BMP receptor type-2 sequence variant 1 (human)" EXACT [PRO:DNx]
xref: UniProtKB_VAR:VAR_013670
is_a: PR:Q13873 ! bone morphogenetic protein receptor type-2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000000161
name: BMP receptor type-2 sequence variant C420R (human)
def: "A bone morphogenetic protein receptor type-2 (human) that has an Arg residue at the position equivalent to Cys-420 of the amino acid sequence represented by UniProtKB:Q13873-1. Example: UniProtKB:Q13873-1, Cys-420, CHEBI:29952." [PMID:11115378, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hBMPR2/var:C420R" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q13873-1, Cys-420, CHEBI:29952" NARROW PRO-proteoform-std [PRO:DAN]
synonym: "BMP receptor type-2 sequence variant 8 (human)" EXACT [PRO:DNx]
xref: UniProtKB_VAR:VAR_013677
is_a: PR:Q13873 ! bone morphogenetic protein receptor type-2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000000037
name: BMP receptor type-2
def: "A TGF-beta superfamily receptor type-2 with activin receptor domain that is a translation product of the human BMPR2 gene or a 1:1 ortholog thereof. Bone morphogenetic protein (BMP) signals are transmitted by type 2 and type 1 serine/threonine kinase receptors. Type 2 receptors phosphorylate and activate type 1 receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators." [PRO:CNA]
comment: Category=gene.
synonym: "PPH1" RELATED Gene-based []
synonym: "BMPR2" EXACT PRO-short-label [PRO:DNx]
synonym: "BRK-3" EXACT []
synonym: "BMPR-2" EXACT []
synonym: "BMPR-II" EXACT []
synonym: "BMP type-2 receptor" EXACT []
synonym: "BMP type II receptor" EXACT []
synonym: "bone morphogenetic protein receptor type II" EXACT []
xref: IUPHARobj:1794
xref: PIRSF:PIRSF500434
is_a: PR:000000007 ! TGF-beta superfamily receptor type-2 with activin receptor domain

[Term]
id: PR:000057062
name: bone morphogenetic protein receptor type-2 O-glycosylated 1 (human)
def: "A bone morphogenetic protein receptor type-2 (human) that has been O-glycosylated at the residue equivalent to Thr-137 of the amino acid sequence represented by UniProtKB:Q13873-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:Q13873-1, Thr-137, MOD:00005~GNO:G43417UB." [GlyGen:Q13873-1, PMID:30459171, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hBMPR2/OGlyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q13873-1, Thr-137, MOD:00005~GNO:G43417UB" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:Q13873 ! bone morphogenetic protein receptor type-2 (human)
relationship: has_part GNO:G43417UB ! G43417UB
relationship: has_part MOD:00005 ! O-glycosyl-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000046497
name: bone morphogenetic protein receptor type-2, signal peptide removed form (human)
def: "A bone morphogenetic protein receptor type-2 (human) that has had the signal peptide removed. UniProtKB:Q13873, 27-1038." [PRO:DNx, Reactome:R-HSA-201442]
comment: Category=organism-modification.
synonym: "PRO_0000024415" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hBMPR2/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q13873, 27-1038" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-201442 "PR:000046497 located_in GO:0005886"
intersection_of: PR:Q13873 ! bone morphogenetic protein receptor type-2 (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000000160
name: BMP receptor type-2 sequence variant C347Y (human)
def: "A bone morphogenetic protein receptor type-2 (human) that has a Tyr residue at the position equivalent to Cys-347 of the amino acid sequence represented by UniProtKB:Q13873-1. Example: UniProtKB:Q13873-1, Cys-347, CHEBI:46858." [PMID:10973254, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hBMPR2/var:C347Y" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q13873-1, Cys-347, CHEBI:46858" NARROW PRO-proteoform-std [PRO:DAN]
synonym: "BMP receptor type-2 sequence variant 7 (human)" EXACT [PRO:DNx]
xref: UniProtKB_VAR:VAR_013676
is_a: PR:Q13873 ! bone morphogenetic protein receptor type-2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q13873-2
name: bone morphogenetic protein receptor type-2 isoform h2 (human)
def: "A bone morphogenetic protein receptor type-2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13873-2." [PRO:DNx, UniProtKB:Q13873]
comment: Category=organism-sequence.
synonym: "hBMPR2/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q13873-2
is_a: PR:Q13873 ! bone morphogenetic protein receptor type-2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000000152
name: BMP receptor type-2 sequence variant R491W (human)
def: "A bone morphogenetic protein receptor type-2 (human) that has a Trp residue at the position equivalent to Arg-491 of the amino acid sequence represented by UniProtKB:Q13873-1. Example: UniProtKB:Q13873-1, Arg-491, CHEBI:29954." [PMID:10903931, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hBMPR2/var:R491W" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q13873-1, Arg-491, CHEBI:29954" NARROW PRO-proteoform-std [PRO:DAN]
synonym: "BMP receptor type-2 sequence variant 12 (human)" EXACT [PRO:DNx]
xref: UniProtKB_VAR:VAR_013681
is_a: PR:Q13873 ! bone morphogenetic protein receptor type-2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000000153
name: BMP receptor type-2 sequence variant K512T (human)
def: "A bone morphogenetic protein receptor type-2 (human) that has a Thr residue at the position equivalent to Lys-512 of the amino acid sequence represented by UniProtKB:Q13873-1. Example: UniProtKB:Q13873-1, Lys-512, CHEBI:30013." [PMID:11115378, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hBMPR2/var:K512T" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q13873-1, Lys-512, CHEBI:30013" NARROW PRO-proteoform-std [PRO:DAN]
synonym: "BMP receptor type-2 sequence variant 13 (human)" EXACT [PRO:DNx]
xref: UniProtKB_VAR:VAR_013682
is_a: PR:Q13873 ! bone morphogenetic protein receptor type-2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000000150
name: BMP receptor type-2 sequence variant D485G (human)
def: "A bone morphogenetic protein receptor type-2 (human) that has a Gly residue at the position equivalent to Asp-485 of the amino acid sequence represented by UniProtKB:Q13873-1. Example: UniProtKB:Q13873-1, Asp-485, CHEBI:29947." [PMID:10973254, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hBMPR2/var:D485G" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q13873-1, Asp-485, CHEBI:29947" NARROW PRO-proteoform-std [PRO:DAN]
synonym: "BMP receptor type-2 sequence variant 10 (human)" EXACT [PRO:DNx]
xref: UniProtKB_VAR:VAR_013679
is_a: PR:Q13873 ! bone morphogenetic protein receptor type-2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000000151
name: BMP receptor type-2 sequence variant R491Q (human)
def: "A bone morphogenetic protein receptor type-2 (human) that has a Gln residue at the position equivalent to Arg-491 of the amino acid sequence represented by UniProtKB:Q13873-1. Example: UniProtKB:Q13873-1, Arg-491, CHEBI:30011." [PMID:10903931, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hBMPR2/var:R491Q" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q13873-1, Arg-491, CHEBI:30011" NARROW PRO-proteoform-std [PRO:DAN]
synonym: "BMP receptor type-2 sequence variant 11 (human)" EXACT [PRO:DNx]
xref: UniProtKB_VAR:VAR_013680
is_a: PR:Q13873 ! bone morphogenetic protein receptor type-2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000000156
name: BMP receptor type-2 sequence variant C118W (human)
def: "A bone morphogenetic protein receptor type-2 (human) that has a Trp residue at the position equivalent to Cys-118 of the amino acid sequence represented by UniProtKB:Q13873-1. Example: UniProtKB:Q13873-1, Cys-118, CHEBI:29954." [PMID:10973254, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hBMPR2/var:C118W" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q13873-1, Cys-118, CHEBI:29954" NARROW PRO-proteoform-std [PRO:DAN]
synonym: "BMP receptor type-2 sequence variant 3 (human)" EXACT [PRO:DNx]
xref: UniProtKB_VAR:VAR_013672
is_a: PR:Q13873 ! bone morphogenetic protein receptor type-2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000000157
name: BMP receptor type-2 sequence variant C123R (human)
def: "A bone morphogenetic protein receptor type-2 (human) that has an Arg residue at the position equivalent to Cys-123 of the amino acid sequence represented by UniProtKB:Q13873-1. Example: UniProtKB:Q13873-1, Cys-123, CHEBI:29952." [PMID:11115378, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hBMPR2/var:C123R" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q13873-1, Cys-123, CHEBI:29952" NARROW PRO-proteoform-std [PRO:DAN]
synonym: "BMP receptor type-2 sequence variant 4 (human)" EXACT [PRO:DNx]
xref: UniProtKB_VAR:VAR_013673
is_a: PR:Q13873 ! bone morphogenetic protein receptor type-2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000000154
name: BMP receptor type-2 sequence variant N519K (human)
def: "A bone morphogenetic protein receptor type-2 (human) that has a Lys residue at the position equivalent to Asn-519 of the amino acid sequence represented by UniProtKB:Q13873-1. Example: UniProtKB:Q13873-1, Asn-519, CHEBI:29967." [PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hBMPR2/var:N519K" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q13873-1, Asn-519, CHEBI:29967" NARROW PRO-proteoform-std [PRO:DAN]
synonym: "BMP receptor type-2 sequence variant 14 (human)" EXACT [PRO:DNx]
xref: UniProtKB_VAR:VAR_013683
is_a: PR:Q13873 ! bone morphogenetic protein receptor type-2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000000155
name: BMP receptor type-2 sequence variant C117Y (human)
def: "A bone morphogenetic protein receptor type-2 (human) that has a Tyr residue at the position equivalent to Cys-117 of the amino acid sequence represented by UniProtKB:Q13873-1. Example: UniProtKB:Q13873-1, Cys-117, CHEBI:46858." [PMID:11015450, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hBMPR2/var:C117Y" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q13873-1, Cys-117, CHEBI:46858" NARROW PRO-proteoform-std [PRO:DAN]
synonym: "BMP receptor type-2 sequence variant 2 (human)" EXACT [PRO:DNx]
xref: UniProtKB_VAR:VAR_013671
is_a: PR:Q13873 ! bone morphogenetic protein receptor type-2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q13873-1
name: bone morphogenetic protein receptor type-2 isoform 1 (human)
def: "A BMP receptor type-2 isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hBMPR2/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q13873-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000148 ! BMP receptor type-2 isoform 1

[Term]
id: PR:000000158
name: BMP receptor type-2 sequence variant C123S (human)
def: "A bone morphogenetic protein receptor type-2 (human) that has a Ser residue at the position equivalent to Cys-123 of the amino acid sequence represented by UniProtKB:Q13873-1. Example: UniProtKB:Q13873-1, Cys-123, CHEBI:29999." [PMID:11115378, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hBMPR2/var:C123S" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q13873-1, Cys-123, CHEBI:29999" NARROW PRO-proteoform-std [PRO:DAN]
synonym: "BMP receptor type-2 sequence variant 5 (human)" EXACT [PRO:DNx]
xref: UniProtKB_VAR:VAR_013674
is_a: PR:Q13873 ! bone morphogenetic protein receptor type-2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000000159
name: BMP receptor type-2 sequence variant E224D (human)
def: "A bone morphogenetic protein receptor type-2 (human) that has an Asp residue at the position equivalent to Glu-224 of the amino acid sequence represented by UniProtKB:Q13873-1. Example: UniProtKB:Q13873-1, Glu-224, CHEBI:29958." [PMID:11115378, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hBMPR2/var:E224D" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q13873-1, Glu-224, CHEBI:29958" NARROW PRO-proteoform-std [PRO:DAN]
synonym: "BMP receptor type-2 sequence variant 6 (human)" EXACT [PRO:DNx]
xref: UniProtKB_VAR:VAR_013675
is_a: PR:Q13873 ! bone morphogenetic protein receptor type-2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000000162
name: BMP receptor type-2 sequence variant C483R (human)
def: "A bone morphogenetic protein receptor type-2 (human) that has an Arg residue at the position equivalent to Cys-483 of the amino acid sequence represented by UniProtKB:Q13873-1. Example: UniProtKB:Q13873-1, Cys-483, CHEBI:29952." [PMID:11015450, PMID:12358323, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hBMPR2/var:C483R" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q13873-1, Cys-483, CHEBI:29952" NARROW PRO-proteoform-std [PRO:DAN]
synonym: "BMP receptor type-2 sequence variant 9 (human)" EXACT [PRO:DNx]
xref: UniProtKB_VAR:VAR_013678
is_a: PR:Q13873 ! bone morphogenetic protein receptor type-2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens