[Term]
id: PR:P36898
name: bone morphogenetic protein receptor type-1B (mouse)
def: "A BMP receptor type-1B that is encoded in the genome of mouse." [OMA:P36898, PRO:DNx]
comment: Category=organism-gene.
synonym: "Bmpr1b" RELATED Gene-based [UniProtKB:P36898]
synonym: "Acvrlk6" RELATED Gene-based [UniProtKB:P36898]
synonym: "mBMPR1B" EXACT PRO-short-label [PRO:DNx]
synonym: "SKR6 (mouse)" EXACT [UniProtKB:P36898]
synonym: "ALK-6 (mouse)" EXACT [UniProtKB:P36898]
synonym: "CDw293 (mouse)" EXACT [UniProtKB:P36898]
synonym: "BMPR-1B (mouse)" EXACT [UniProtKB:P36898]
synonym: "BMP type-1B receptor (mouse)" EXACT [UniProtKB:P36898]
synonym: "activin receptor-like kinase 6 (mouse)" EXACT [UniProtKB:P36898]
synonym: "serine/threonine-protein kinase receptor R6 (mouse)" EXACT [UniProtKB:P36898]
xref: UniProtKB:P36898
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000036 ! BMP receptor type-1B
relationship: has_gene_template MGI:107191 ! Bmpr1b (mouse)

[Term]
id: PR:Q09488
name: serine/threonine-protein kinase receptor sma-6 (worm)
def: "A BMP receptor type-1B that is encoded in the genome of worm." [OMA:Q09488, PRO:DNx]
comment: Category=organism-gene.
synonym: "sma-6" RELATED Gene-based [UniProtKB:Q09488]
synonym: "C32D5.2" RELATED Gene-based [UniProtKB:Q09488]
synonym: "BMPR1B (worm)" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q09488
intersection_of: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans
intersection_of: PR:000000036 ! BMP receptor type-1B
relationship: has_gene_template WormBase:WBGene00004860 ! sma-6 (worm)

[Term]
id: PR:000046496
name: bone morphogenetic protein receptor type-1B, signal peptide removed phosphoserine form (human)
def: "A bone morphogenetic protein receptor type-1B (human) that has had the signal peptide removed and that includes at least one phosphorylated serine. UniProtKB:O00238, 14-502, MOD:00046." [PRO:DNx, Reactome:R-HSA-201814]
comment: Category=organism-modification.
synonym: "hBMPR1B/SigPep-/PhosSer+" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000024412, MOD:00046" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:O00238, 14-502, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-201814 "PR:000046496 located_in GO:0005886"
intersection_of: has_part MOD:00046 ! O-phospho-L-serine
intersection_of: PR:O00238 ! bone morphogenetic protein receptor type-1B (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000000500
name: BMP receptor type-1B isoform 1 phosphorylated 1
def: "A BMP receptor type-1B isoform 1 phosphorylated form in which the phosphorylation occurs within the GS-motif by the BMP receptor type-2 upon BMP ligand binding." [PRO:CNA]
comment: Category=modification. Note: Phosphorylation can occur at Ser and/or Thr residues.
synonym: "active receptor" RELATED []
synonym: "BMPR1B/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "BMP receptor type-1B isoform 1 phosphorylated by BMPR2" EXACT []
is_a: PR:000000383 ! BMP receptor type-1B isoform 1 phosphorylated form
relationship: has_part MOD:00696 ! phosphorylated residue

[Term]
id: PR:000000036
name: BMP receptor type-1B
def: "A TGF-beta superfamily receptor type-1 that is a translation product of the human BMPR1B gene or a 1:1 ortholog thereof. Bone morphogenetic protein (BMP) signals are transmitted by type 2 and type 1 serine/threonine kinase receptors. Type 2 receptors phosphorylate and activate type 1 receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMPS/OP-1." [PRO:CNA]
comment: Category=gene.
synonym: "SKR6" EXACT []
synonym: "ALK-6" EXACT []
synonym: "BMPR1B" EXACT PRO-short-label [PRO:DNx]
synonym: "CDw293" EXACT []
synonym: "Acvrlk6" RELATED Gene-based []
synonym: "BMPR-1B" EXACT []
synonym: "BMP type-1B receptor" EXACT []
synonym: "activin receptor-like kinase 6" EXACT []
synonym: "serine/threonine-protein kinase receptor R6" EXACT []
xref: IUPHARobj:1789
is_a: PR:000000006 ! TGF-beta superfamily receptor type-1

[Term]
id: PR:000000145
name: BMP receptor type-1B isoform 1
def: "A BMP receptor type-1B that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O00238-1 or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=sequence. Phosphorylation information from rat [PMID:9766532].
synonym: "BMPR1B/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000036 ! BMP receptor type-1B

[Term]
id: PR:000000147
name: BMP receptor type-1B sequence variant R486W (human)
def: "A bone morphogenetic protein receptor type-1B (human) that has a Trp residue at the position equivalent to Arg-486 of the amino acid sequence represented by UniProtKB:O00238-1. Example: UniProtKB:O00238-1, Arg-486, CHEBI:29954." [PMID:14523231, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hBMPR1B/var:R486W" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O00238-1, Arg-486, CHEBI:29954" NARROW PRO-proteoform-std [PRO:DAN]
synonym: "BMP receptor type-1B sequence variant 2 (human)" EXACT [PRO:DNx]
xref: UniProtKB_VAR:VAR_023820
is_a: PR:O00238 ! bone morphogenetic protein receptor type-1B (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000000146
name: BMP receptor type-1B sequence variant I200K (human)
def: "A bone morphogenetic protein receptor type-1B (human) that has a Lys residue at the position equivalent to Ile-200 of the amino acid sequence represented by UniProtKB:O00238-1. Example: UniProtKB:O00238-1, Ile-200, CHEBI:29967." [PMID:14523231, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hBMPR1B/var:I200K" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O00238-1, Ile-200, CHEBI:29967" NARROW PRO-proteoform-std [PRO:DAN]
synonym: "BMP receptor type-1B sequence variant 1 (human)" EXACT [PRO:DNx]
xref: UniProtKB_VAR:VAR_023819
is_a: PR:O00238 ! bone morphogenetic protein receptor type-1B (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O00238-2
name: bone morphogenetic protein receptor type-1B isoform h2 (human)
def: "A bone morphogenetic protein receptor type-1B (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O00238-2." [PRO:DNx, UniProtKB:O00238]
comment: Category=organism-sequence.
synonym: "hBMPR1B/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O00238-2
is_a: PR:O00238 ! bone morphogenetic protein receptor type-1B (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O00238
name: bone morphogenetic protein receptor type-1B (human)
def: "A BMP receptor type-1B that is encoded in the genome of human." [PRO:CNA, UniProtKB:O00238]
comment: Category=organism-gene.
synonym: "BMPR1B" RELATED Gene-based [UniProtKB:O00238]
synonym: "hBMPR1B" EXACT PRO-short-label [PRO:DNx]
synonym: "CDw293 (human)" EXACT [UniProtKB:O00238]
synonym: "BMPR-1B (human)" EXACT [UniProtKB:O00238]
synonym: "BMP type-1B receptor (human)" EXACT [UniProtKB:O00238]
xref: DTO:03100045
xref: UniProtKB:O00238
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000036 ! BMP receptor type-1B
relationship: has_gene_template HGNC:1077 ! BMPR1B (human)

[Term]
id: PR:O00238-1
name: bone morphogenetic protein receptor type-1B isoform 1 (human)
def: "A BMP receptor type-1B isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hBMPR1B/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O00238-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000145 ! BMP receptor type-1B isoform 1

[Term]
id: PR:000046495
name: bone morphogenetic protein receptor type-1B, signal peptide removed form (human)
def: "A bone morphogenetic protein receptor type-1B (human) that has had the signal peptide removed. UniProtKB:O00238, 14-502." [PRO:DNx, Reactome:R-HSA-201657]
comment: Category=organism-modification.
synonym: "PRO_0000024412" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hBMPR1B/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O00238, 14-502" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-201657 "PR:000046495 located_in GO:0005886"
intersection_of: PR:O00238 ! bone morphogenetic protein receptor type-1B (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q05438
name: bone morphogenetic protein receptor type-1B (chicken)
def: "A BMP receptor type-1B that is encoded in the genome of chicken." [OMA:Q05438, PRO:DNx]
comment: Category=organism-gene.
synonym: "BMPR1B" RELATED Gene-based [UniProtKB:Q05438]
synonym: "chick-BMPR1B" EXACT PRO-short-label [PRO:DNx]
synonym: "SKR6 (chicken)" EXACT [UniProtKB:Q05438]
synonym: "ALK-6 (chicken)" EXACT [UniProtKB:Q05438]
synonym: "RPK-1 (chicken)" EXACT [UniProtKB:Q05438]
synonym: "BMPR-1B (chicken)" EXACT [UniProtKB:Q05438]
synonym: "BMP type-1B receptor (chicken)" EXACT [UniProtKB:Q05438]
synonym: "activin receptor-like kinase 6 (chicken)" EXACT [UniProtKB:Q05438]
synonym: "serine/threonine-protein kinase receptor R6 (chicken)" EXACT [UniProtKB:Q05438]
xref: UniProtKB:Q05438
intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus
intersection_of: PR:000000036 ! BMP receptor type-1B
relationship: has_gene_template NCBIGene:396030 ! BMPR1B (chicken)

[Term]
id: PR:000036426
name: BMP receptor type-1B isoform 1 phosphorylated 1 (human)
def: "A BMP receptor type-1B isoform 1 phosphorylated 1 in human." [PMID:10051328, PMID:14523231, PRO:CNA]
comment: Category=organism-modification.
synonym: "hBMPR1B/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000500 ! BMP receptor type-1B isoform 1 phosphorylated 1
relationship: has_part MOD:00696 ! phosphorylated residue

[Term]
id: PR:000036425
name: BMP receptor type-1B isoform 1 phosphorylated 1 (mouse)
def: "A BMP receptor type-1B isoform 1 phosphorylated 1 in mouse." [PMID:10631181, PMID:10712517, PMID:14523231, PRO:CNA]
comment: Category=organism-modification.
synonym: "mBMPR1B/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000500 ! BMP receptor type-1B isoform 1 phosphorylated 1
relationship: has_part MOD:00696 ! phosphorylated residue

[Term]
id: PR:000000383
name: BMP receptor type-1B isoform 1 phosphorylated form
def: "A BMP receptor type-1B isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]
comment: Category=modification.
synonym: "BMPR1B/iso:1/PhosRes+" EXACT PRO-short-label [PRO:DNx]
intersection_of: has_part MOD:00696 ! phosphorylated residue
intersection_of: PR:000000145 ! BMP receptor type-1B isoform 1

[Term]
id: PR:P36898-1
name: bone morphogenetic protein receptor type-1B isoform 1 (mouse)
def: "A BMP receptor type-1B isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mBMPR1B/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P36898-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000145 ! BMP receptor type-1B isoform 1

[Term]
id: PR:Q569A5
name: receptor protein serine/threonine kinase (rat)
def: "A BMP receptor type-1B that is encoded in the genome of rat." [PANTHER:PTHR23255:SF35, PRO:DNx]
comment: Category=organism-gene.
synonym: "rBMPR1B" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q569A5
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000000036 ! BMP receptor type-1B
relationship: has_gene_template RGD:1595863 ! Bmpr1b (rat)