[Term]
id: PR:000000138
name: BMP receptor type-1A sequence variant C82Y (human)
def: "A bone morphogenetic protein receptor type-1A (human) that has a Tyr residue at the position equivalent to Cys-82 of the amino acid sequence represented by UniProtKB:P36894. UniProtKB:P36894, Cys-82, CHEBI:46858." [PMID:12417513, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hBMPR1A/var:C82Y" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P36894, Cys-82, CHEBI:46858" EXACT PRO-proteoform-std [PRO:DAN]
synonym: "BMP receptor type-1A sequence variant 2 (human)" EXACT [PRO:DNx]
xref: UniProtKB_VAR:VAR_022829
is_a: PR:P36894 ! bone morphogenetic protein receptor type-1A (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000000139
name: BMP receptor type-1A sequence variant C124R (human)
def: "A bone morphogenetic protein receptor type-1A (human) that has an Arg residue at the position equivalent to Cys-124 of the amino acid sequence represented by UniProtKB:P36894. UniProtKB:P36894, Cys-124, CHEBI:29952." [PMID:11536076, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hBMPR1A/var:C124R" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P36894, Cys-124, CHEBI:29952" EXACT PRO-proteoform-std [PRO:DAN]
synonym: "BMP receptor type-1A sequence variant 3 (human)" EXACT [PRO:DNx]
xref: UniProtKB_VAR:VAR_015533
is_a: PR:P36894 ! bone morphogenetic protein receptor type-1A (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P36894-1
name: bone morphogenetic protein receptor type-1A isoform 1 (human)
def: "A BMP receptor type-1A isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hBMPR1A/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P36894-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000136 ! BMP receptor type-1A isoform 1

[Term]
id: PR:000000035
name: BMP receptor type-1A
def: "A TGF-beta superfamily receptor type-1 that is a translation product of the human BMPR1A gene or a 1:1 ortholog thereof. Bone morphogenetic protein (BMP) signals are transmitted by type 2 and type 1 serine/threonine kinase receptors. Type 2 receptors phosphorylate and activate type 1 receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2 and BMP4." [PRO:CNA]
comment: Category=gene.
synonym: "ALK3" RELATED Gene-based []
synonym: "Bmpr" RELATED Gene-based []
synonym: "SKR5" EXACT []
synonym: "ALK-3" EXACT []
synonym: "CD292" EXACT []
synonym: "BMPR1A" EXACT PRO-short-label [PRO:DNx]
synonym: "ACVRLK3" RELATED Gene-based []
synonym: "BMPR-1A" EXACT []
synonym: "BMP type-1A receptor" EXACT []
synonym: "BMP-2/BMP-4 receptor" EXACT []
synonym: "activin receptor-like kinase 3" EXACT []
synonym: "serine/threonine-protein kinase receptor R5" EXACT []
xref: IUPHARobj:1786
is_a: PR:000000006 ! TGF-beta superfamily receptor type-1

[Term]
id: PR:000046494
name: bone morphogenetic protein receptor type-1A, signal peptide removed phosphorylated 2 (human)
def: "A bone morphogenetic protein receptor type-1A (human) that has had the signal peptide removed and has been post-translationally modified to include phosphoserine at positions 215, 216, 218 and 220 of the amino acid sequence represented by UniProtKB:P36894. UniProtKB:P36894, 24-532, Ser-215/Ser-216/Ser-218/Ser-220, MOD:00046." [PRO:DNx, Reactome:R-HSA-201448]
comment: Category=organism-modification.
synonym: "hBMPR1A/SigPep-/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000024410, Ser-215/Ser-216/Ser-218/Ser-220, MOD:00046" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P36894, 24-532, Ser-215/Ser-216/Ser-218/Ser-220, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-201448 "PR:000046494 located_in GO:0005886"
is_a: PR:P36894 ! bone morphogenetic protein receptor type-1A (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part SO:0000418 ! signal_peptide

[Term]
id: PR:000000144
name: BMP receptor type-1A sequence variant M470T (human)
def: "A bone morphogenetic protein receptor type-1A (human) that has a Thr residue at the position equivalent to Met-470 of the amino acid sequence represented by UniProtKB:P36894. UniProtKB:P36894, Met-470, CHEBI:30013." [PMID:12630959, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hBMPR1A/var:M470T" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P36894, Met-470, CHEBI:30013" EXACT PRO-proteoform-std [PRO:DAN]
synonym: "BMP receptor type-1A sequence variant 8 (human)" EXACT [PRO:DNx]
xref: UniProtKB_VAR:VAR_022832
is_a: PR:P36894 ! bone morphogenetic protein receptor type-1A (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P36894
name: bone morphogenetic protein receptor type-1A (human)
def: "A BMP receptor type-1A that is encoded in the genome of human." [PRO:CNA, UniProtKB:P36894]
comment: Category=organism-gene.
synonym: "ALK3" RELATED Gene-based [UniProtKB:P36894]
synonym: "BMPR1A" RELATED Gene-based [UniProtKB:P36894]
synonym: "ACVRLK3" RELATED Gene-based [UniProtKB:P36894]
synonym: "hBMPR1A" EXACT PRO-short-label [PRO:DNx]
synonym: "SKR5 (human)" EXACT [UniProtKB:P36894]
synonym: "ALK-3 (human)" EXACT [UniProtKB:P36894]
synonym: "CD292 (human)" EXACT [UniProtKB:P36894]
synonym: "BMPR-1A (human)" EXACT [UniProtKB:P36894]
synonym: "BMP type-1A receptor (human)" EXACT [UniProtKB:P36894]
synonym: "activin receptor-like kinase 3 (human)" EXACT [UniProtKB:P36894]
synonym: "serine/threonine-protein kinase receptor R5 (human)" EXACT [UniProtKB:P36894]
xref: DTO:03100044
xref: UniProtKB:P36894
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000035 ! BMP receptor type-1A
relationship: has_gene_template HGNC:1076 ! BMPR1A (human)

[Term]
id: PR:000000141
name: BMP receptor type-1A sequence variant A338D (human)
def: "A bone morphogenetic protein receptor type-1A (human) that has an Asp residue at the position equivalent to Ala-338 of the amino acid sequence represented by UniProtKB:P36894. UniProtKB:P36894, Ala-338, CHEBI:29958." [PMID:11536076, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hBMPR1A/var:A338D" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P36894, Ala-338, CHEBI:29958" EXACT PRO-proteoform-std [PRO:DAN]
synonym: "BMP receptor type-1A sequence variant 5 (human)" EXACT [PRO:DNx]
xref: UniProtKB_VAR:VAR_015534
is_a: PR:P36894 ! bone morphogenetic protein receptor type-1A (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000000140
name: BMP receptor type-1A sequence variant C130R (human)
def: "A bone morphogenetic protein receptor type-1A (human) that has an Arg residue at the position equivalent to Cys-130 of the amino acid sequence represented by UniProtKB:P36894. UniProtKB:P36894, Cys-130, CHEBI:29952." [PMID:12136244, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hBMPR1A/var:C130R" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P36894, Cys-130, CHEBI:29952" EXACT PRO-proteoform-std [PRO:DAN]
synonym: "BMP receptor type-1A sequence variant 4 (human)" EXACT [PRO:DNx]
xref: UniProtKB_VAR:VAR_022830
is_a: PR:P36894 ! bone morphogenetic protein receptor type-1A (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000000143
name: BMP receptor type-1A sequence variant R443C (human)
def: "A bone morphogenetic protein receptor type-1A (human) that has a Cys residue at the position equivalent to Arg-443 of the amino acid sequence represented by UniProtKB:P36894. UniProtKB:P36894, Arg-443, CHEBI:29950." [PMID:12417513, PMID:17344846, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hBMPR1A/var:R443C" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P36894, Arg-443, CHEBI:29950" EXACT PRO-proteoform-std [PRO:DAN]
synonym: "BMP receptor type-1A sequence variant 7 (human)" EXACT [PRO:DNx]
xref: UniProtKB_VAR:VAR_022831
is_a: PR:P36894 ! bone morphogenetic protein receptor type-1A (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000000137
name: BMP receptor type-1A sequence variant Y62D (human)
def: "A bone morphogenetic protein receptor type-1A (human) that has an Asp residue at the position equivalent to Tyr-62 of the amino acid sequence represented by UniProtKB:P36894. UniProtKB:P36894, Tyr-62, CHEBI:29958." [PMID:12417513, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hBMPR1A/var:Y62D" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P36894, Tyr-62, CHEBI:29958" EXACT PRO-proteoform-std [PRO:DAN]
synonym: "BMP receptor type-1A sequence variant 1 (human)" EXACT [PRO:DNx]
xref: UniProtKB_VAR:VAR_022828
is_a: PR:P36894 ! bone morphogenetic protein receptor type-1A (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000036422
name: BMP receptor type-1A isoform 1 phosphorylated 1 (human)
def: "A BMP receptor type-1A isoform 1 phosphorylated 1 in human." [PMID:10712517, PMID:12065756, PMID:12829744, PMID:15940369, PRO:CNA]
comment: Category=organism-modification.
synonym: "hBMPR1A/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000498 ! BMP receptor type-1A isoform 1 phosphorylated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000046493
name: bone morphogenetic protein receptor type-1A, signal peptide removed form (human)
def: "A bone morphogenetic protein receptor type-1A (human) that has had the signal peptide removed. UniProtKB:P36894, 24-532." [PRO:DNx, Reactome:R-HSA-201480]
comment: Category=organism-modification.
synonym: "PRO_0000024410" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hBMPR1A/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P36894, 24-532" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-201480 "PR:000046493 located_in GO:0005886"
intersection_of: PR:P36894 ! bone morphogenetic protein receptor type-1A (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000036424
name: BMP receptor type-1A isoform 1 phosphorylated 2 (human)
def: "A BMP receptor type-1A isoform 1 phosphorylated 2 in human. UniProtKB:P36894-1, Ser-215/Ser-216/Ser-218/Ser-220, MOD:00046." [PMID:17081983, PRO:CNA]
comment: Category=organism-modification.
synonym: "hBMPR1A/iso:1/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P36894-1, Ser-215/Ser-216/Ser-218/Ser-220, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000499 ! BMP receptor type-1A isoform 1 phosphorylated 2
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000000142
name: BMP receptor type-1A sequence variant C376Y (human)
def: "A bone morphogenetic protein receptor type-1A (human) that has a Tyr residue at the position equivalent to Cys-376 of the amino acid sequence represented by UniProtKB:P36894. UniProtKB:P36894, Cys-376, CHEBI:46858." [PMID:11536076, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hBMPR1A/var:C376Y" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P36894, Cys-376, CHEBI:46858" EXACT PRO-proteoform-std [PRO:DAN]
synonym: "BMP receptor type-1A sequence variant 6 (human)" EXACT [PRO:DNx]
xref: UniProtKB_VAR:VAR_015535
is_a: PR:P36894 ! bone morphogenetic protein receptor type-1A (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens