[Term]
id: PR:000000116
name: noggin sequence variant Y222D (human)
def: "A noggin (human) that has an Asp residue at the position equivalent to Tyr-222 of the amino acid sequence represented by UniProtKB:Q13253. UniProtKB:Q13253, Tyr-222, CHEBI:29958." [PMID:10080184, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hNOG/var:Y222D" EXACT PRO-short-label [PRO:DNx]
synonym: "noggin sequence variant 9 (human)" EXACT [PRO:DNx]
synonym: "UniProtKB:Q13253, Tyr-222, CHEBI:29958" EXACT PRO-proteoform-std [PRO:DAN]
xref: UniProtKB_VAR:VAR_011366
is_a: PR:Q13253 ! noggin (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000000114
name: noggin sequence variant I220N (human)
def: "A noggin (human) that has an Asn residue at the position equivalent to Ile-220 of the amino acid sequence represented by UniProtKB:Q13253. UniProtKB:Q13253, Ile-220, CHEBI:50347." [PMID:10080184, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hNOG/var:I220N" EXACT PRO-short-label [PRO:DNx]
synonym: "noggin sequence variant 7 (human)" EXACT [PRO:DNx]
synonym: "UniProtKB:Q13253, Ile-220, CHEBI:50347" EXACT PRO-proteoform-std [PRO:DAN]
xref: UniProtKB_VAR:VAR_011364
is_a: PR:Q13253 ! noggin (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000000115
name: noggin sequence variant Y222C (human)
def: "A noggin (human) that has a Cys residue at the position equivalent to Tyr-222 of the amino acid sequence represented by UniProtKB:Q13253. UniProtKB:Q13253, Tyr-222, CHEBI:29950." [PMID:10080184, PMID:11545688, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hNOG/var:Y222C" EXACT PRO-short-label [PRO:DNx]
synonym: "noggin sequence variant 8 (human)" EXACT [PRO:DNx]
synonym: "UniProtKB:Q13253, Tyr-222, CHEBI:29950" EXACT PRO-proteoform-std [PRO:DAN]
xref: UniProtKB_VAR:VAR_011365
is_a: PR:Q13253 ! noggin (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000000112
name: noggin sequence variant R204L (human)
def: "A noggin (human) that has a Leu residue at the position equivalent to Arg-204 of the amino acid sequence represented by UniProtKB:Q13253. UniProtKB:Q13253, Arg-204, CHEBI:30006." [PMID:11545688, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hNOG/var:R204L" EXACT PRO-short-label [PRO:DNx]
synonym: "noggin sequence variant 5 (human)" EXACT [PRO:DNx]
synonym: "UniProtKB:Q13253, Arg-204, CHEBI:30006" EXACT PRO-proteoform-std [PRO:DAN]
xref: UniProtKB_VAR:VAR_011326
is_a: PR:Q13253 ! noggin (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000000107
name: noggin sequence variant P35S (human)
def: "A noggin (human) that has a Ser residue at the position equivalent to Pro-35 of the amino acid sequence represented by UniProtKB:Q13253. UniProtKB:Q13253, Pro-35, CHEBI:29999." [PMID:11857750, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hNOG/var:P35S" EXACT PRO-short-label [PRO:DNx]
synonym: "noggin sequence variant 1 (human)" EXACT [PRO:DNx]
synonym: "UniProtKB:Q13253, Pro-35, CHEBI:29999" EXACT PRO-proteoform-std [PRO:DAN]
xref: UniProtKB_VAR:VAR_018324
is_a: PR:Q13253 ! noggin (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000000110
name: noggin sequence variant C184Y (human)
def: "A noggin (human) that has a Tyr residue at the position equivalent to Cys-184 of the amino acid sequence represented by UniProtKB:Q13253. UniProtKB:Q13253, Cys-184, CHEBI:46858." [PMID:11846737, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hNOG/var:C184Y" EXACT PRO-short-label [PRO:DNx]
synonym: "noggin sequence variant 3 (human)" EXACT [PRO:DNx]
synonym: "UniProtKB:Q13253, Cys-184, CHEBI:46858" EXACT PRO-proteoform-std [PRO:DAN]
xref: UniProtKB_VAR:VAR_018325
is_a: PR:Q13253 ! noggin (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000000111
name: noggin sequence variant G189C (human)
def: "A noggin (human) that has a Cys residue at the position equivalent to Gly-189 of the amino acid sequence represented by UniProtKB:Q13253. UniProtKB:Q13253, Gly-189, CHEBI:29950." [PMID:99178269, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hNOG/var:G189C" EXACT PRO-short-label [PRO:DNx]
synonym: "noggin sequence variant 4 (human)" EXACT [PRO:DNx]
synonym: "UniProtKB:Q13253, Gly-189, CHEBI:29950" EXACT PRO-proteoform-std [PRO:DAN]
xref: UniProtKB_VAR:VAR_011362
is_a: PR:Q13253 ! noggin (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000000109
name: noggin sequence variant P35R (human)
def: "A noggin (human) that has an Arg residue at the position equivalent to Pro-35 of the amino acid sequence represented by UniProtKB:Q13253. UniProtKB:Q13253, Pro-35, CHEBI:29952." [PMID:11545688, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hNOG/var:P35R" EXACT PRO-short-label [PRO:DNx]
synonym: "noggin sequence variant 2 (human)" EXACT [PRO:DNx]
synonym: "UniProtKB:Q13253, Pro-35, CHEBI:29952" EXACT PRO-proteoform-std [PRO:DAN]
xref: UniProtKB_VAR:VAR_011361
is_a: PR:Q13253 ! noggin (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000000108
name: noggin sequence variant P223L (human)
def: "A noggin (human) that has a Leu residue at the position equivalent to Pro-223 of the amino acid sequence represented by UniProtKB:Q13253. UniProtKB:Q13253, Pro-223, CHEBI:30006." [PMID:10080184, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hNOG/var:P223L" EXACT PRO-short-label [PRO:DNx]
synonym: "noggin sequence variant 10 (human)" EXACT [PRO:DNx]
synonym: "UniProtKB:Q13253, Pro-223, CHEBI:30006" EXACT PRO-proteoform-std [PRO:DAN]
xref: UniProtKB_VAR:VAR_011367
is_a: PR:Q13253 ! noggin (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000000021
name: noggin
def: "A protein that is a translation product of the human NOG gene or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=gene.
synonym: "NOG" EXACT PRO-short-label [PRO:DNx]
xref: PIRSF:PIRSF008129
xref: PANTHER:PTHR10494:SF2
is_a: PR:000000001 ! protein

[Term]
id: PR:000057007
name: noggin O-glycosylated 1 (human)
def: "A noggin (human) that has been O-glycosylated at the residue equivalent to Thr-81 of the amino acid sequence represented by UniProtKB:Q13253-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:Q13253-1, Thr-81, MOD:00005~GNO:G43417UB." [GlyGen:Q13253-1, PMID:30459171, PRO:DNx]
comment: Category=organism-modification. Requested by=GlyGen.
synonym: "hNOG/OGlyco:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q13253-1, Thr-81, MOD:00005~GNO:G43417UB" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:Q13253 ! noggin (human)
relationship: has_part GNO:G43417UB ! G43417UB
relationship: has_part MOD:00005 ! O-glycosyl-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q13253
name: noggin (human)
def: "A noggin that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q13253]
comment: Category=organism-gene.
synonym: "NOG" RELATED Gene-based [UniProtKB:Q13253]
synonym: "hNOG" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q13253
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000021 ! noggin
relationship: has_gene_template HGNC:7866 ! NOG (human)

[Term]
id: PR:Q13253-1
name: noggin isoform 1 (human)
def: "A noggin isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hNOG/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q13253-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000106 ! noggin isoform 1

[Term]
id: PR:000036421
name: noggin isoform 1, signal peptide removed form (human)
def: "A noggin isoform 1, signal peptide removed form in human. UniProtKB:Q13253-1, 28-232." [PMID:11562478, PMID:12478285, PRO:CNA]
comment: Category=organism-modification.
synonym: "PRO_0000019813" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hNOG/iso:1/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q13253-1, 28-232" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-201809 "PR:000036421 located_in GO:0005576"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000457 ! noggin isoform 1, signal peptide removed form

[Term]
id: PR:000000113
name: noggin sequence variant W217G (human)
def: "A noggin (human) that has a Gly residue at the position equivalent to Trp-217 of the amino acid sequence represented by UniProtKB:Q13253. UniProtKB:Q13253, Trp-217, CHEBI:29947." [PMID:10080184, PRO:CNA, PRO:DAN]
comment: Category=organism-sequence.
synonym: "hNOG/var:W217G" EXACT PRO-short-label [PRO:DNx]
synonym: "noggin sequence variant 6 (human)" EXACT [PRO:DNx]
synonym: "UniProtKB:Q13253, Trp-217, CHEBI:29947" EXACT PRO-proteoform-std [PRO:DAN]
xref: UniProtKB_VAR:VAR_011363
is_a: PR:Q13253 ! noggin (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens