Protein Ontology Report - hTLR3 PR:O15455 - http://purl.obolibrary.org/obo/PR_O15455

This page represents a class of proteins encompassing all the protein products of the TLR3 gene in human .

Ontology Information
PRO ID	PR:O15455 Show OBO stanza / PAF
PRO name	Toll-like receptor 3 (human)
Synonyms	PRO-short-label: hTLR3 EXACT: CD283 (human) Gene-based: TLR3
Definition	A Toll-like receptor 3 that is encoded in the genome of human. [PRO:CNA, UniProtKB:O15455]
PRO Category	organism-gene
Parent	PR:000001154 Toll-like receptor 3
Terms by PRO Category	Retrieve All terms OBO Stanza / PAF Organism-Specific Category Number of Terms organism-gene 1 organism-sequence 2 organism-modification 1
Term Hierarchy Visualization	DAG     OLS     Cytoscape

Related Cross References
DB identifiers	HGNC:11849, UniProtKB:O15455

Interactive Sequence View Select/align proteoforms across species

Protein Forms Display Category: All All organism-gene organism-sequence organism-modification
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

hTLR3 forms found in complexes

hTLR3 Component Complexes PR:000001154 TLR3 PR:000037302 viral dsRNA:TLR3 complex PR:000037305 hTLR3/SigPep- PR:000037364 IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human) PR:000037305 hTLR3/SigPep- PR:000037362 K63-pUb-rip1:ticam1:activated TLR3 complex (human) PR:000037305 hTLR3/SigPep- PR:000037360 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) PR:000037305 hTLR3/SigPep- PR:000037358 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) PR:000037305 hTLR3/SigPep- PR:000037356 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) PR:000037305 hTLR3/SigPep- PR:000037354 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) PR:000037305 hTLR3/SigPep- PR:000037344 traf6:ticam1:activated TLR3 complex (human) PR:000037305 hTLR3/SigPep- PR:000037342 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:activated TLR3 complex (human) PR:000037305 hTLR3/SigPep- PR:000037340 pUbtraf6:ticam1:activated TLR3 complex (human) PR:000037305 hTLR3/SigPep- PR:000037338 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:activated TLR3 complex (human) PR:000037305 hTLR3/SigPep- PR:000037336 rip1:rip3:ticam1:activated TLR3 complex (human) PR:000037305 hTLR3/SigPep- PR:000037334 rip1:ticam1:activated TLR3 complex (human) PR:000037305 hTLR3/SigPep- PR:000037332 rip3:ticam1:activated TLR3 complex (human) PR:000037305 hTLR3/SigPep- PR:000037330 SARM:ticam1:activated TLR3 complex (human) PR:000037305 hTLR3/SigPep- PR:000037322 p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) PR:000037305 hTLR3/SigPep- PR:000037320 p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) PR:000037305 hTLR3/SigPep- PR:000037315 K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) PR:000037305 hTLR3/SigPep- PR:000037310 traf3:ticam1:activated TLR3 complex (human) PR:000037305 hTLR3/SigPep- PR:000037307 ticam1:viral dsRNA:TLR3 complex (human) PR:000037305 hTLR3/SigPep- PR:000037303 viral dsRNA:TLR3 complex (human) PR:000037305 hTLR3/SigPep- PR:000037368 pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex (human) PR:000037305 hTLR3/SigPep- PR:000037366 fadd:rip1:ticam1:activated TLR3 complex (human)

Functional Annotation PRO Centric View GO Centric View

PRO Term GO Annotation Evidence PR:000037366 fadd:rip1:ticam1:activated TLR3 complex (human) located_in GO:0010008 endosome membrane Reactome:REACT_6783 participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783 participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783 PR:000037364 IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human) located_in GO:0010008 endosome membrane Reactome:REACT_6783 participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783 participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783 PR:000037356 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) located_in GO:0010008 endosome membrane Reactome:REACT_6783 participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783 participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783 PR:000037362 K63-pUb-rip1:ticam1:activated TLR3 complex (human) located_in GO:0010008 endosome membrane Reactome:REACT_6783 participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783 participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783 PR:000037354 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) located_in GO:0010008 endosome membrane Reactome:REACT_6783 participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783 participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783 PR:000037360 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) located_in GO:0010008 endosome membrane Reactome:REACT_6783 participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783 participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783 PR:000037358 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) located_in GO:0010008 endosome membrane Reactome:REACT_6783 participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783 participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783 PR:000037368 pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex (human) located_in GO:0010008 endosome membrane Reactome:REACT_6783 participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783 participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783 PR:000037322 p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) located_in GO:0010008 endosome membrane Reactome:REACT_6783 participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783 participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783 PR:000037310 traf3:ticam1:activated TLR3 complex (human) located_in GO:0010008 endosome membrane Reactome:REACT_6783 participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783 participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783 PR:000037338 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:activated TLR3 complex (human) located_in GO:0010008 endosome membrane Reactome:REACT_6783 participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783 participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783 PR:000037303 viral dsRNA:TLR3 complex (human) located_in GO:0010008 endosome membrane Reactome:REACT_6783 participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783 participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783 PR:000037315 K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) located_in GO:0010008 endosome membrane Reactome:REACT_6783 participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783 participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783 PR:000037307 ticam1:viral dsRNA:TLR3 complex (human) located_in GO:0010008 endosome membrane Reactome:REACT_6783 participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783 participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783 PR:000037330 SARM:ticam1:activated TLR3 complex (human) located_in GO:0010008 endosome membrane Reactome:REACT_6783 participates_in GO:0034128 negative regulation of MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783 participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783 PR:000037344 traf6:ticam1:activated TLR3 complex (human) located_in GO:0010008 endosome membrane Reactome:REACT_6783 participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783 participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783 PR:000037332 rip3:ticam1:activated TLR3 complex (human) located_in GO:0010008 endosome membrane Reactome:REACT_6783 participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783 participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783 PR:000037320 p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) located_in GO:0010008 endosome membrane Reactome:REACT_6783 participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783 participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783 PR:000037334 rip1:ticam1:activated TLR3 complex (human) located_in GO:0010008 endosome membrane Reactome:REACT_6783 participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783 participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783 PR:000037340 pUbtraf6:ticam1:activated TLR3 complex (human) located_in GO:0010008 endosome membrane Reactome:REACT_6783 participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783 participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783 PR:000037336 rip1:rip3:ticam1:activated TLR3 complex (human) located_in GO:0010008 endosome membrane Reactome:REACT_6783 participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783 participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783 PR:000037342 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:activated TLR3 complex (human) located_in GO:0010008 endosome membrane Reactome:REACT_6783 participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783 participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783 Biological Process GO Term Protein Forms & Complexes Evidence GO:0002756 MyD88-independent toll-like receptor signaling pathway PR:000037303 viral dsRNA:TLR3 complex (human) Reactome:REACT_6783 PR:000037307 ticam1:viral dsRNA:TLR3 complex (human) Reactome:REACT_6783 PR:000037310 traf3:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037315 K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037320 p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037322 p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037332 rip3:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037334 rip1:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037336 rip1:rip3:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037338 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037340 pUbtraf6:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037342 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037344 traf6:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037354 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037356 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037358 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037360 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037362 K63-pUb-rip1:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037364 IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037366 fadd:rip1:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037368 pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 GO:0034128 negative regulation of MyD88-independent toll-like receptor signaling pathway PR:000037330 SARM:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 GO:0034138 toll-like receptor 3 signaling pathway PR:000037303 viral dsRNA:TLR3 complex (human) Reactome:REACT_6783 PR:000037307 ticam1:viral dsRNA:TLR3 complex (human) Reactome:REACT_6783 PR:000037310 traf3:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037315 K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037320 p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037322 p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037330 SARM:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037332 rip3:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037334 rip1:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037336 rip1:rip3:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037338 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037340 pUbtraf6:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037342 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037344 traf6:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037354 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037356 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037358 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037360 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037362 K63-pUb-rip1:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037364 IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037366 fadd:rip1:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037368 pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 Cellular Location GO Term Protein Forms & Complexes Evidence GO:0010008 endosome membrane PR:000037303 viral dsRNA:TLR3 complex (human) Reactome:REACT_6783 PR:000037307 ticam1:viral dsRNA:TLR3 complex (human) Reactome:REACT_6783 PR:000037310 traf3:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037315 K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037320 p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037322 p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037330 SARM:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037332 rip3:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037334 rip1:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037336 rip1:rip3:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037338 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037340 pUbtraf6:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037342 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037344 traf6:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037354 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037356 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037358 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037360 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037362 K63-pUb-rip1:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037364 IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037366 fadd:rip1:ticam1:activated TLR3 complex (human) Reactome:REACT_6783 PR:000037368 pro-caspase-8:fadd:rip1:ticam1:activated TLR3 complex (human) Reactome:REACT_6783

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