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Protein Ontology Report - hSMAD2/iso:1/Phos:1

PR:000025934 - http://purl.obolibrary.org/obo/PR_000025934
Ontology Information
PRO ID PR:000025934 Show OBO stanza / PAF
PRO name smad2 isoform 1 phosphorylated 1 (human)
Synonyms
PRO-short-label: hSMAD2/iso:1/Phos:1
Definition A smad2 isoform 1 phosphorylated 1 in human. This form is phosphorylated in the two last Ser of the C-terminal SSxS motif. UniProtKB:Q15796-1, Ser-465/Ser-467, MOD:00046. [PMID:8980228, PMID:9346966]
Comment Kinase=("TGFBR1"; PR:000025963; Ser-465/Ser-467).
PRO Category organism-modification
Parent PR:000000650 smad2 isoform 1 phosphorylated 1
Term Hierarchy Visualization DAG     Cytoscape


Functional Annotation
PRO Term GO Annotation Evidence
PR:000025934
hSMAD2/iso:1/Phos:1
Ser-465/Ser-467, MOD:00046
has_function GO:0003713 transcription coactivator activity PMID:9689110
has_function GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity PMID:8980228, PMID:9346966
has_function GO:0046332 SMAD binding with PR:Q13485 hSMAD4 PMID:9311995
has_modification MOD:00046 O-phospho-L-serine PMID:9136927
located_in GO:0005634 nucleus PMID:9006934, PMID:9346966
participates_in GO:0006355 regulation of transcription, DNA-templated PMID:15690394, PMID:9689110
participates_in GO:0007165 signal transduction PMID:8752209, PMID:8980228, PMID:9346966
participates_in GO:0007179 transforming growth factor beta receptor signaling pathway PMID:8752209, PMID:8980228
participates_in GO:0007183 SMAD protein complex assembly PMID:9346966
Molecular Function GO Term Protein Forms & Complexes Evidence
GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity PR:000025934 hSMAD2/iso:1/Phos:1
Ser-465/Ser-467, MOD:00046
PMID:8980228, PMID:9346966
GO:0046332 SMAD binding PR:000025934 hSMAD2/iso:1/Phos:1
Ser-465/Ser-467, MOD:00046
with PR:Q13485 hSMAD4
PMID:9311995
GO:0003713 transcription coactivator activity PR:000025934 hSMAD2/iso:1/Phos:1
Ser-465/Ser-467, MOD:00046
PMID:9689110
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0006355 regulation of transcription, DNA-templated PR:000025934 hSMAD2/iso:1/Phos:1
Ser-465/Ser-467, MOD:00046
PMID:15690394, PMID:9689110
GO:0007183 SMAD protein complex assembly PR:000025934 hSMAD2/iso:1/Phos:1
Ser-465/Ser-467, MOD:00046
PMID:9346966
GO:0007165 signal transduction PR:000025934 hSMAD2/iso:1/Phos:1
Ser-465/Ser-467, MOD:00046
PMID:8752209, PMID:8980228, PMID:9346966
GO:0007179 transforming growth factor beta receptor signaling pathway PR:000025934 hSMAD2/iso:1/Phos:1
Ser-465/Ser-467, MOD:00046
PMID:8752209, PMID:8980228
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005634 nucleus PR:000025934 hSMAD2/iso:1/Phos:1
Ser-465/Ser-467, MOD:00046
PMID:9006934, PMID:9346966

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