PRO ID |
PR:000021977
Show OBO stanza
|
PRO name |
interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 3 |
Synonyms |
PRO-short-label: |
IRAK1/iso:1/Phos:3 |
EXACT: |
interleukin-1 receptor-associated kinase 1 active; pp-IRAK1 |
|
Definition |
An interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated form in which the phosphorylation by interleukin-1 receptor-associated kinase 4 (IRAK-4) occurs on the conserved Thr residue (Thr-209 in human) located near the N terminus of the kinase domain, and on a Thr residue located in the activation loop (Thr-387 in human). The latter phosphorylation is the second step following the activation of the TLR/IL-1 receptor complex. Example: UniProtKB:P51617-1, Thr-209/Thr-387, MOD:00047.
[PMID:14625308, PRO:CNA, PRO:DAN]
|
PRO Category |
modification |
Parent |
PR:000021971 interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated form |
Term Hierarchy Visualization |
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