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Protein Ontology Report - DNMT1

PR:000006606 - http://purl.obolibrary.org/obo/PR_000006606
Ontology Information
PRO ID PR:000006606 Show OBO stanza / PAF
PRO name DNA (cytosine-5)-methyltransferase 1
Synonyms
PRO-short-label: DNMT1
EXACT: CXXC-type zinc finger protein 9; DNA MTase HsaI; DNA MTase MmuI; DNA methyltransferase HsaI; DNA methyltransferase MmuI; Dnmt1; M.HsaI; M.MmuI; MCMT; met-1
Gene-based: AIM; CXXC9; DNMT; Met1; Uim
Definition A protein that is a translation product of the human DNMT1 gene or a 1:1 ortholog thereof. [PRO:DNx]
PRO Category gene
Parent PR:000000001 protein
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 4
sequence 0 organism-sequence 14
modification 0 organism-modification 3
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

DNMT1 forms found in complexes
DNMT1 Component Complexes
PR:000037504 hDNMT1/UnPhos:1 PR:000037517 DNMT1:PCNA:UHRF1 complex (human)

Functional Annotation
PRO Term GO Annotation Evidence
PR:000037506
hDNMT1/Phos:2
Ser-127/Ser-143, MOD:00046
capable_of GO:0005515 protein binding decreased relative to PR:000037504 hDNMT1/UnPhos:1 with PR:Q96T88 hUHRF1 PMID:20613874
capable_of GO:0005515 protein binding decreased relative to PR:000037504 hDNMT1/UnPhos:1 with PR:P12004 hPCNA PMID:20613874
PR:000037505
hDNMT1/Phos:1
Ser-127, MOD:00046
capable_of GO:0005515 protein binding decreased relative to PR:000037504 hDNMT1/UnPhos:1 with PR:P12004 hPCNA PMID:20613874
capable_of GO:0005515 protein binding decreased relative to PR:000037504 hDNMT1/UnPhos:1 with PR:Q96T88 hUHRF1 PMID:20613874
PR:000037504
hDNMT1/UnPhos:1
Ser-127/Ser-143, PR:000026291
capable_of GO:0005515 protein binding with PR:P12004 hPCNA PMID:20613874
capable_of GO:0005515 protein binding with PR:Q96T88 hUHRF1 PMID:20613874
PR:000037517
DNMT1:PCNA:UHRF1 complex (human)
associated_with_disease_suppression DOID:162 cancer PMID:20613874

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