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Protein Ontology Report - BCL2

PR:000002307 - http://purl.obolibrary.org/obo/PR_000002307
Ontology Information
PRO ID PR:000002307 Show OBO stanza / PAF
PRO name apoptosis regulator Bcl-2
Synonyms
PRO-short-label: BCL2
Gene-based: Bcl-2
Definition A Bcl-2-like apoptosis inhibitor that is a translation product of the human BCL2 gene or a 1:1 ortholog thereof. [PRO:WCB]
PRO Category gene
Parent PR:000002186 Bcl-2-like apoptosis inhibitor
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 4
sequence 2 organism-sequence 4
modification 6 organism-modification 5
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:P10417-1
mBCL2/iso:Alpha
capable_of GO:0005515 protein binding with PR:000026785 mBID/iso:1/Clv:1 PMID:11583631
participates_in GO:0043066 negative regulation of apoptotic process PMID:11583631
PR:000036633
mBCL2/iso:1/Phos:1
Ser-70, MOD:00046 		capable_of GO:0019902 phosphatase binding with PR:P67774 cow-PPP2CA PMID:9115213, PMID:9852076
capable_of GO:0005515 protein binding with PR:Q07813 mBAX PMID:9115213, PMID:9852076
located_in GO:0016020 membrane PMID:9115213, PMID:9852076
participates_in GO:0043066 negative regulation of apoptotic process PMID:9115213, PMID:9852076
PR:P10415-1
hBCL2/iso:Alpha
capable_of GO:0005515 protein binding with PR:P63328 mPPP3CA PMID:9109491
capable_of GO:0005515 protein binding with PR:Q07813 mBAX PMID:9109491
located_in GO:0005886 plasma membrane PMID:9109491
participates_in GO:0070885 negative regulation of calcineurin-NFAT signaling cascade PMID:9109491
PR:000027461
hBCL2/iso:1/Phos:2
Thr-74, MOD:00047 		participates_in GO:0043066 negative regulation of apoptotic process PMID:12039864
PR:000027463
hBCL2/iso:1/Phos:3
Thr-69, MOD:00047|Ser-70/Ser-87, MOD:00046 		capable_of NOT GO:0005515 protein binding with PR:Q14457 hBECN1 PMID:18570871, PMID:19029119
participates_in GO:0016239 positive regulation of macroautophagy PMID:18570871, PMID:19029119
PR:000027465
hBCL2/iso:1/Phos:4
Thr-69, MOD:00047|Ser-87, MOD:00046 		participates_in GO:0043065 positive regulation of apoptotic process PMID:15703383
PR:000027467
hBCL2/iso:1/Phos:5
Thr-56, MOD:00047 		participates_in GO:0045839 negative regulation of mitotic nuclear division PMID:10766756
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0043066 negative regulation of apoptotic process PR:000027461 hBCL2/iso:1/Phos:2
Thr-74, MOD:00047
PMID:12039864
PR:000036633 mBCL2/iso:1/Phos:1
Ser-70, MOD:00046
PMID:9115213, PMID:9852076
PR:P10417-1 mBCL2/iso:Alpha

PMID:11583631
GO:0016239 positive regulation of macroautophagy PR:000027463 hBCL2/iso:1/Phos:3
Thr-69, MOD:00047|Ser-70/Ser-87, MOD:00046
PMID:18570871, PMID:19029119
GO:0045839 negative regulation of mitotic nuclear division PR:000027467 hBCL2/iso:1/Phos:5
Thr-56, MOD:00047
PMID:10766756
GO:0043065 positive regulation of apoptotic process PR:000027465 hBCL2/iso:1/Phos:4
Thr-69, MOD:00047|Ser-87, MOD:00046
PMID:15703383
GO:0070885 negative regulation of calcineurin-NFAT signaling cascade PR:P10415-1 hBCL2/iso:Alpha

PMID:9109491
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0016020 membrane PR:000036633 mBCL2/iso:1/Phos:1
Ser-70, MOD:00046
PMID:9115213, PMID:9852076
GO:0005886 plasma membrane PR:P10415-1 hBCL2/iso:Alpha

PMID:9109491

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