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Protein Ontology Report - IRAK3

PR:000001784 - http://purl.obolibrary.org/obo/PR_000001784
Ontology Information
PRO ID PR:000001784 Show OBO stanza / PAF
PRO name interleukin-1 receptor-associated kinase 3
Synonyms
PRO-short-label: IRAK3
EXACT: IL-1 receptor-associated kinase M; IRAK-3; IRAK-M; inactive IL-1 receptor-associated kinase 3
Definition An interleukin-1 receptor-associated kinase IRAK1/3 that is a translation product of the human IRAK3 gene or a 1:1 ortholog thereof. [PMID:12150927, PRO:CNA]
PRO Category gene
Parent PR:000001781 interleukin-1 receptor-associated kinase IRAK1/3
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 3
sequence 1 organism-sequence 4
modification 0 organism-modification 0
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

IRAK3 forms found in complexes
IRAK3 Component Complexes
PR:Q8K4B2 mIRAK3 PR:000027267 IRAK3:IRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse)

Functional Annotation
PRO Term GO Annotation Evidence
PR:Q8K4B2
mIRAK3
participates_in GO:0034122 negative regulation of toll-like receptor signaling pathway PMID:12150927
PR:Q9Y616-1
hIRAK3/iso:1
capable_of GO:0005515 protein binding with PR:Q99836 hMYD88 PMID:10383454
participates_in GO:0034122 negative regulation of toll-like receptor signaling pathway PMID:10383454
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0034122 negative regulation of toll-like receptor signaling pathway PR:Q8K4B2 mIRAK3

PMID:12150927
PR:Q9Y616-1 hIRAK3/iso:1

PMID:10383454

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