PRO ID |
PR:000000669
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/ PAF
|
PRO name |
cation channel sperm-associated protein 1 |
Synonyms |
PRO-short-label: |
CATSPER1 |
BROAD: |
CatSper |
EXACT: |
CatSper1 |
|
Definition |
A CatSper channel protein that is a translation product of the human CATSPER1 gene or a 1:1 ortholog thereof. In mammals, four CatSper ion channel subunit genes (CatSpers 1-4) are required for sperm cell hyperactivation and male fertility. The four proteins assemble (presumably as a tetramer) to form a sperm-specific, alkalinization-activated Ca(2+)-selective channel. CatSper channels seem to require auxiliary subunits, such as CatSperB (PR:000000672). In common with other channels, CatSper1 proteins have an architecture consisting of six transmembrane domains (S1-S6), arranged in a voltage sensor (S1-S4) and pore modules (S5-P-S6), and with both N and C termini on the intracellular side of the membrane. Unique to this class is the His-rich N terminus that seems to be involved the pH sensitivity of the channel calcium currents.
[PRO:CNA]
|
PRO Category |
gene |
Parent |
PR:000044645 CatSper channel protein |
Terms by PRO Category |
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Category |
Number of Terms |
Category |
Number of Terms |
gene
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1 |
organism-gene
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2 |
sequence
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1 |
organism-sequence
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2 |
modification
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1 |
organism-modification
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0 |
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