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Protein Ontology Report - SMAD1

PR:000000363 - http://purl.obolibrary.org/obo/PR_000000363
Ontology Information
PRO ID PR:000000363 Show OBO stanza / PAF
PRO name smad1
Synonyms
PRO-short-label: SMAD1
EXACT: BSP-1; Dwf-A; JV4-1; MAD homolog 1; Mad-related protein 1; Mad1; SMAD 1; SMAD family member 1; dwarfin-A; mothers against DPP homolog 1; mothers-against-DPP-related 1; transforming growth factor-beta-signaling protein 1
Gene-based: BSP1; MADH1; MADR1
Definition A BMP receptor-regulated smad protein that is a translation product of the human SMAD1 gene or a 1:1 ortholog thereof. [PMID:10708949, PRO:CNA]
PRO Category gene
Parent PR:000000038 BMP receptor-regulated smad protein
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 3
sequence 1 organism-sequence 3
modification 5 organism-modification 5
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:P70340-1
mSMAD1/iso:1
located_in GO:0005737 cytoplasm PMID:10504300, PMID:17356069
participates_in GO:0030509 BMP signaling pathway PMID:15198985, PMID:15331632, PMID:17356069
PR:000026334
hSMAD1/iso:1/Phos:1
Ser-463/Ser-465, MOD:00046 		capable_of GO:0046332 SMAD binding with PR:Q13485 hSMAD4 PMID:9136927
located_in GO:0005634 nucleus PMID:11509558, PMID:9759503
participates_in GO:0030509 BMP signaling pathway PMID:8653785
participates_in GO:0007165 signal transduction PMID:9759503
PR:000026724
mSMAD1/iso:1/Phos:1
Ser-463/Ser-465, MOD:00046 		capable_of GO:0005515 protein binding with PR:Q8BGV5 mZNF8 PMID:12370310
capable_of GO:0005515 protein binding with PR:Q04211 mBTG2 PMID:15542835
capable_of GO:0005515 protein binding with PR:Q9QZH6 mECSIT PMID:14633973
located_in GO:0005634 nucleus PMID:10504300, PMID:12151307, PMID:12370310
located_in GO:0005769 early endosome PMID:17592637
part_of GO:0005667 transcription factor complex PMID:14633973
participates_in GO:0030509 BMP signaling pathway PMID:12370310, PMID:15198985
participates_in GO:0008285 negative regulation of cell population proliferation PMID:15899870
PR:Q15797-1
hSMAD1/iso:1
capable_of GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific PMID:10708949
capable_of GO:0005102 signaling receptor binding PMID:9136927, PMID:9748228
capable_of GO:0005515 protein binding with PR:Q7Z3T8 hZFYVE16 PMID:17356069
located_in GO:0005737 cytoplasm PMID:11509558
participates_in GO:0007165 signal transduction PMID:8637600
participates_in GO:0030509 BMP signaling pathway PMID:8653785
PR:000036553
hSMAD1/iso:1/PhosUbiq:1
Ser-463/Ser-465, MOD:00046|MOD:01148 		participates_in GO:0030514 negative regulation of BMP signaling pathway PMID:12857866
PR:000000647
SMAD1/iso:1/Phos:1
Ser-463/Ser-465, MOD:00046 		capable_of GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific PMID:10708949
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0030514 negative regulation of BMP signaling pathway PR:000036553 hSMAD1/iso:1/PhosUbiq:1
Ser-463/Ser-465, MOD:00046|MOD:01148
PMID:12857866
GO:0030509 BMP signaling pathway PR:000026334 hSMAD1/iso:1/Phos:1
Ser-463/Ser-465, MOD:00046
PMID:8653785
PR:000026724 mSMAD1/iso:1/Phos:1
Ser-463/Ser-465, MOD:00046
PMID:12370310, PMID:15198985
PR:P70340-1 mSMAD1/iso:1

PMID:15198985, PMID:15331632, PMID:17356069
PR:Q15797-1 hSMAD1/iso:1

PMID:8653785
GO:0008285 negative regulation of cell population proliferation PR:000026724 mSMAD1/iso:1/Phos:1
Ser-463/Ser-465, MOD:00046
PMID:15899870
GO:0007165 signal transduction PR:000026334 hSMAD1/iso:1/Phos:1
Ser-463/Ser-465, MOD:00046
PMID:9759503
PR:Q15797-1 hSMAD1/iso:1

PMID:8637600
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005634 nucleus PR:000026334 hSMAD1/iso:1/Phos:1
Ser-463/Ser-465, MOD:00046
PMID:11509558, PMID:9759503
PR:000026724 mSMAD1/iso:1/Phos:1
Ser-463/Ser-465, MOD:00046
PMID:10504300, PMID:12151307, PMID:12370310
GO:0005737 cytoplasm PR:P70340-1 mSMAD1/iso:1

PMID:10504300, PMID:17356069
PR:Q15797-1 hSMAD1/iso:1

PMID:11509558
GO:0005769 early endosome PR:000026724 mSMAD1/iso:1/Phos:1
Ser-463/Ser-465, MOD:00046
PMID:17592637

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