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Protein Ontology Report - CREBBP

PR:000000090 - http://purl.obolibrary.org/obo/PR_000000090
Ontology Information
PRO ID PR:000000090 Show OBO stanza / PAF
PRO name CREB-binding protein
Synonyms
PRO-short-label: CREBBP
EXACT: protein-lysine acetyltransferase CREBBP
Gene-based: CBP
Definition A transcription adapter with TAZ, KIX and bromo-domains that is a translation product of the human CREBBP gene or a 1:1 ortholog thereof. [PRO:CNA]
PRO Category gene
Parent PR:000000031 transcription adapter with TAZ, KIX and bromo-domains
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 3
sequence 1 organism-sequence 4
modification 4 organism-modification 1
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:000036453
mCREBBP/iso:1/Me:1
Arg-600/Arg-624, MOD:00658 		located_in GO:0005634 nucleus PMID:11701890
part_of NOT GO:0000123 histone acetyltransferase complex PMID:11701890
PR:Q92793-1
hCREBBP/iso:1
capable_of GO:0005515 protein binding with PR:P04637 hTP53 PMID:9194564
capable_of GO:0005515 protein binding with PR:Q16665 hHIF1A PMID:9887100
capable_of GO:0005515 protein binding with PR:P42858 hHTT PMID:10823891
capable_of GO:0005515 protein binding with PR:Q9UER7 hDAXX PMID:11799127
capable_of GO:0005515 protein binding with PR:P17096 hHMGA1 PMID:10428834
capable_of GO:0005515 protein binding with PR:Q04206 hRELA PMID:16291753
capable_of GO:0005515 protein binding with PR:P55209 hNAP1L1 PMID:11940655
capable_of GO:0005515 protein binding with PR:Q14686 hNCOA6 PMID:10866662
capable_of GO:0005515 protein binding with PR:Q99967-1 hCITED2/iso:1 PMID:99104162
capable_of GO:0016407 acetyltransferase activity PMID:11742995
capable_of GO:0005515 protein binding with PR:Q92793 hCREBBP PMID:8684459
capable_of GO:0004402 histone acetyltransferase activity PMID:11742995
capable_of GO:0003713 transcription coactivator activity PMID:10733899, PMID:10893273, PMID:12169688, PMID:12586840, PMID:8684459
located_in GO:0005634 nucleus PMID:7913207
part_of GO:0000123 histone acetyltransferase complex PMID:9742083
participates_in GO:0006355 regulation of transcription, DNA-templated PMID:12169688, PMID:7913207
participates_in GO:0016573 histone acetylation PMID:11742995
participates_in GO:0045893 positive regulation of transcription, DNA-templated PMID:11742995
PR:P45481-1
mCREBBP/iso:1
capable_of GO:0004402 histone acetyltransferase activity PMID:11867645
capable_of GO:0005515 protein binding with PR:Q60749 mKHDRBS1 PMID:12496368
capable_of GO:0005515 protein binding with PR:P88946 orfK9 (tax435895) PMID:10733899
capable_of GO:0016407 acetyltransferase activity PMID:12496368
capable_of GO:0005515 protein binding with PR:P02340 mTP53 PMID:9194565
located_in GO:0005634 nucleus PMID:11963968, PMID:12496368
participates_in GO:0045893 positive regulation of transcription, DNA-templated PMID:15464984
PR:000000266
hCREBBP/var:R1378P
Arg-1378, CHEBI:50342 		associated_with_disease_progression DOID:1933 Rubinstein-Taybi syndrome PMID:11331617
capable_of NOT GO:0004402 histone acetyltransferase activity PMID:11331617
has_agent SO:0001559 polypeptide_loss_of_function_variant PMID:11331617
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0006355 regulation of transcription, DNA-templated PR:Q92793-1 hCREBBP/iso:1

PMID:12169688, PMID:7913207
GO:0016573 histone acetylation PR:Q92793-1 hCREBBP/iso:1

PMID:11742995
GO:0045893 positive regulation of transcription, DNA-templated PR:P45481-1 mCREBBP/iso:1

PMID:15464984
PR:Q92793-1 hCREBBP/iso:1

PMID:11742995
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005634 nucleus PR:000036453 mCREBBP/iso:1/Me:1
Arg-600/Arg-624, MOD:00658
PMID:11701890
PR:P45481-1 mCREBBP/iso:1

PMID:11963968, PMID:12496368
PR:Q92793-1 hCREBBP/iso:1

PMID:7913207

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