iPTMnet Report for Q9Y6X8 (ZHX2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y6X8 / ZHX2_HUMAN
Protein Name Zinc fingers and homeoboxes protein 2
Gene Name Name: ZHX2
Synonyms:AFR1,KIAA0854,RAF;
Organism Homo sapiens (Human)

PRO ID PR:Q9Y6X8
DAG View
PRO Name zinc fingers and homeoboxes protein 2 (human)
Definition A zinc fingers and homeoboxes protein 2 that is encoded in the genome of human.
Short Label hZHX2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y6X8 (ZHX2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S7 Phosphorylation PhosphoSitePlus
T8 Phosphorylation PhosphoSitePlus
T9 Phosphorylation PhosphoSitePlus
T37 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 23186163, 24275569
T207 Phosphorylation PhosphoSitePlus   UniProt 23186163
T215 Phosphorylation PhosphoSitePlus
T220 Phosphorylation PhosphoSitePlus
T222 Phosphorylation PhosphoSitePlus
T264 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...32574038, 34725712, 31492838, 29351928, 34019948, 29485866, 35254053, 28657654
T265 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...32574038, 34725712, 31492838, 29351928, 34019948, 29485866, 35254053, 28657654
Y267 Phosphorylation PhosphoSitePlus
S269 Phosphorylation PhosphoSitePlus
T344 Phosphorylation HPRD   PhosphoSitePlus 18491316
T355 Phosphorylation HPRD   PhosphoSitePlus 18491316
T401 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...32574038, 34725712, 31492838, 29351928, 34019948, 29485866, 35254053, 28657654
T401 Phosphorylation RLIMS-P 27034005
T411 Phosphorylation PhosphoSitePlus
T439 Phosphorylation PhosphoSitePlus
S442 Phosphorylation PhosphoSitePlus
K455 Ubiquitination PhosphoSitePlus
Y470 Phosphorylation PhosphoSitePlus
S516 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...32574038, 34725712, 31492838, 29351928, 34019948, 29485866, 35254053, 28657654
T566 Phosphorylation PhosphoSitePlus
S569 Phosphorylation PhosphoSitePlus
S586 Phosphorylation PhosphoSitePlus
S625 Phosphorylation PhosphoSitePlus
S628 Phosphorylation PhosphoSitePlus
T654 Phosphorylation PhosphoSitePlus
Y658 Phosphorylation PhosphoSitePlus
Y705 Phosphorylation PhosphoSitePlus
T713 Phosphorylation PhosphoSitePlus
S719 Phosphorylation PhosphoSitePlus
S769 Phosphorylation PhosphoSitePlus
S775 Phosphorylation PhosphoSitePlus
S776 Phosphorylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P01116 (KRAS) Y64 Q9Y6X8 (ZHX2) decreased_association eFIP 30644389


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S7 F7 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
T8 K8 Biomuta DOID:1324 / lung cancer [ icgc ]
T207 A207 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]
T222 A222 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T264 A264 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T265 A265 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T566 I566 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S625 Y625 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
T654 I654 Biomuta [ cosmic ]
S769 L769 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S776 I776 Biomuta DOID:363 / uterine cancer [ icgc ]