iPTMnet Report for Q9Y6Q9 (NCOA3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y6Q9 / NCOA3_HUMAN
Protein Name Nuclear receptor coactivator 3
Gene Name Name: NCOA3
Synonyms:AIB1,BHLHE42,RAC3,TRAM1;
Organism Homo sapiens (Human)

PRO ID PR:Q9Y6Q9
DAG View
PRO Name nuclear receptor coactivator 3 (human)
Definition A nuclear receptor coactivator 3 that is encoded in the genome of human.
Short Label hNCOA3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y6Q9 (NCOA3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 22814378
T24 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P 17646391, 15383283
T24 Phosphorylation P45983 (MAPK8) neXtProt   PhosphoSitePlus 15383283
T24 Phosphorylation Q16539 (MAPK14) neXtProt 15383283
T30 Phosphorylation PhosphoSitePlus
S32 Phosphorylation PhosphoSitePlus
K35 Acetylation PhosphoSitePlus
K65 Ubiquitination PhosphoSitePlus
S90 O-Glycosylation GlyGen 23301498, 30379171, 29351928, ...34019948, 30620550, 35132862, 31492838, 35254053
K97 Ubiquitination PhosphoSitePlus
S101 Phosphorylation PhosphoSitePlus   RLIMS-P 21577200
S102 Phosphorylation PhosphoSitePlus   RLIMS-P 21577200
S102 Phosphorylation P49674 (CSNK1E) PhosphoSitePlus 21577200
K167 Ubiquitination PhosphoSitePlus
T184 Phosphorylation PhosphoSitePlus
K191 Ubiquitination PhosphoSitePlus
S214 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S244 Phosphorylation PhosphoSitePlus
R251 Methylation PhosphoSitePlus
S274 Phosphorylation PhosphoSitePlus
K276 Acetylation PhosphoSitePlus
T282 Phosphorylation PhosphoSitePlus
S284 Phosphorylation PhosphoSitePlus
S287 Phosphorylation PhosphoSitePlus
S288 Phosphorylation PhosphoSitePlus
S306 Phosphorylation PhosphoSitePlus
S505 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   Signor 15383283
S505 Phosphorylation P45983 (MAPK8) neXtProt   PhosphoSitePlus 15383283
S505 Phosphorylation Q16539 (MAPK14) neXtProt   PhosphoSitePlus   Signor 15383283
S509 Phosphorylation PhosphoSitePlus
S543 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   Signor 15383283
S543 Phosphorylation P45983 (MAPK8) neXtProt   PhosphoSitePlus 15383283
S543 Phosphorylation Q16539 (MAPK14) neXtProt   PhosphoSitePlus   Signor 15383283
S551 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 24275569
T557 Phosphorylation PhosphoSitePlus
S563 Phosphorylation PhosphoSitePlus
S569 Phosphorylation PhosphoSitePlus
Y574 Phosphorylation PhosphoSitePlus
S601 Phosphorylation PhosphoSitePlus   Signor   UniProt 19339517
S601 Phosphorylation P48730 (CSNK1D) PhosphoSitePlus   Signor 19339517
K616 Acetylation PhosphoSitePlus   UniProt 10490106
K619 Acetylation PhosphoSitePlus   UniProt 10490106
K620 Acetylation PhosphoSitePlus   UniProt 10490106
K620 Ubiquitination PhosphoSitePlus
S636 Phosphorylation PhosphoSitePlus
S640 Phosphorylation PhosphoSitePlus
S652 O-Glycosylation GlyGen 23301498, 30379171, 29351928, ...34019948, 30620550, 35132862, 31492838, 35254053
T654 O-Glycosylation GlyGen 23301498, 30379171, 29351928, ...34019948, 30620550, 35132862, 31492838, 35254053
K687 Acetylation PhosphoSitePlus   UniProt 19608861
S694 Phosphorylation PhosphoSitePlus   UniProt 23186163
S715 Phosphorylation PhosphoSitePlus
K723 Sumoylation PhosphoSitePlus
K723 Ubiquitination PhosphoSitePlus
S728 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 18669648, 23186163, 22163316
S728 Phosphorylation P06493 (CDK1) PhosphoSitePlus   Signor 22163316
K753 Ubiquitination PhosphoSitePlus
K786 Sumoylation PhosphoSitePlus
K786 Ubiquitination PhosphoSitePlus
S836 Phosphorylation PhosphoSitePlus
K840 Methylation PhosphoSitePlus
R849 Methylation IEDB   PhosphoSitePlus 27503676
S857 O-Glycosylation GlyGen 23301498, 30379171, 29351928, ...34019948, 30620550, 35132862, 31492838, 35254053
S857 Phosphorylation IEDB   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 17646391, 23186163, 16964243, ...32516969, 22505454, 15808510, 29615789, 18669648, 15383283, 30784271, 32647362, 19690332, 20068231
S857 Phosphorylation O15111 (CHUK) PhosphoSitePlus   Signor 22505454, 15383283
S857 Phosphorylation P17612 (PRKACA) PhosphoSitePlus   Signor 22505454, 15383283
S857 Phosphorylation Q16659 (MAPK6) neXtProt   PhosphoSitePlus   Signor 22505454
S857 Phosphorylation Q16877 (PFKFB4) Signor 29615789
S860 O-Glycosylation GlyGen 23301498, 30379171, 29351928, ...34019948, 30620550, 35132862, 31492838, 35254053
S860 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 17646391, 22147914, 15383283
S860 Phosphorylation P45983 (MAPK8) neXtProt   PhosphoSitePlus 15383283
S860 Phosphorylation Q16539 (MAPK14) neXtProt   PhosphoSitePlus   Signor 15383283
S863 O-Glycosylation GlyGen 23301498, 30379171, 29351928, ...34019948, 30620550, 35132862, 31492838, 35254053
S863 Phosphorylation PhosphoSitePlus
S866 Phosphorylation PhosphoSitePlus
S867 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 16964243, 15302935, 18669648, ...22163316, 15383283, 20068231
S867 Phosphorylation P06493 (CDK1) PhosphoSitePlus 22163316
S867 Phosphorylation P45983 (MAPK8) neXtProt   PhosphoSitePlus 15383283
S867 Phosphorylation Q16539 (MAPK14) neXtProt   PhosphoSitePlus   Signor 15383283
T910 O-Glycosylation GlyGen 23301498, 30379171, 29351928, ...34019948, 30620550, 35132862, 31492838, 35254053
T912 O-Glycosylation GlyGen 23301498, 30379171, 29351928, ...34019948, 30620550, 35132862, 31492838, 35254053
T914 O-Glycosylation GlyGen 23301498, 30379171, 29351928, ...34019948, 30620550, 35132862, 31492838, 35254053
S917 O-Glycosylation GlyGen 23301498, 30379171, 29351928, ...34019948, 30620550, 35132862, 31492838, 35254053
K926 Ubiquitination PhosphoSitePlus
R951 Methylation PhosphoSitePlus
S1033 Phosphorylation PhosphoSitePlus   UniProt 23186163, 18313384
S1033 Phosphorylation Q05513 (PRKCZ) PhosphoSitePlus 18313384
S1042 Phosphorylation PhosphoSitePlus 18313384
S1042 Phosphorylation Q05513 (PRKCZ) PhosphoSitePlus 18313384
S1048 Phosphorylation PhosphoSitePlus 18313384
S1048 Phosphorylation Q05513 (PRKCZ) PhosphoSitePlus 18313384
T1059 Phosphorylation PhosphoSitePlus 18313384
T1059 Phosphorylation Q05513 (PRKCZ) PhosphoSitePlus 18313384
S1062 Phosphorylation PhosphoSitePlus 18313384
S1062 Phosphorylation Q05513 (PRKCZ) PhosphoSitePlus 18313384
T1064 Phosphorylation PhosphoSitePlus 18313384
T1064 Phosphorylation Q05513 (PRKCZ) PhosphoSitePlus 18313384
T1067 Phosphorylation PhosphoSitePlus 18313384
T1067 Phosphorylation Q05513 (PRKCZ) PhosphoSitePlus 18313384
K1091 Methylation PhosphoSitePlus
T1114 Phosphorylation PhosphoSitePlus 18313384
T1114 Phosphorylation Q05513 (PRKCZ) PhosphoSitePlus 18313384
R1163 Methylation IEDB 27503676
R1171 Methylation PhosphoSitePlus   UniProt 24129315
R1177 Methylation PhosphoSitePlus   UniProt 24129315
R1188 Methylation PhosphoSitePlus   UniProt 24129315
K1194 Sumoylation PhosphoSitePlus
K1194 Ubiquitination PhosphoSitePlus
S1330 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
Y1357 Phosphorylation PhosphoSitePlus   Signor 18765637
Y1357 Phosphorylation P00519 (ABL1) PhosphoSitePlus   Signor 18765637
Site PTM Type PTM Enzyme Score Source PMID
T24 Phosphorylation HPRD 16135815, 15383283
S101 Phosphorylation PRO 21577200, 18922467
S102 Phosphorylation PRO 21577200, 18922467
S214 Phosphorylation HPRD 17322306, 19651622, 18669648, ...20068231
S274 Phosphorylation HPRD 20068231
T282 Phosphorylation HPRD 20068231
S284 Phosphorylation HPRD 20068231
S287 Phosphorylation HPRD 20068231
S288 Phosphorylation HPRD 20068231
S429 Phosphorylation HPRD 20068231
S505 Phosphorylation HPRD 16135815, 15383283, 16456540
S505 Phosphorylation Q16539 (MAPK14) HPRD 16135815, 15383283, 16456540
S543 Phosphorylation HPRD 16135815, 15383283, 16456540
S543 Phosphorylation Q16539 (MAPK14) HPRD 16135815, 15383283, 16456540
S551 Phosphorylation HPRD 19413330, 18767875, 18669648, ...20068231
S601 Phosphorylation PRO 19339517
S601 Phosphorylation PR:P48730 (hCSNK1D) PRO 19339517
K619 Acetylation PRO 10490106
K619 Acetylation PR:Q09472 (hEP300) PRO 10490106
K620 Acetylation PRO 10490106
K620 Acetylation PR:Q09472 (hEP300) PRO 10490106
K687 Acetylation PRO 19608861
S694 Phosphorylation HPRD 20068231
S728 Phosphorylation HPRD 18669648
S857 Phosphorylation HPRD   PRO 19413330, 16964243, 16135815, ...19651622, 18669648, 15383283, 20068231
S857 Phosphorylation O14920 (IKBKB) HPRD 19413330, 16964243, 16135815, ...19651622, 18669648, 15383283, 20068231
S857 Phosphorylation O15111 (CHUK) HPRD 19413330, 16964243, 16135815, ...19651622, 18669648, 15383283, 20068231
S860 Phosphorylation HPRD 16135815, 15383283, 20068231, ...16456540
S860 Phosphorylation Q16539 (MAPK14) HPRD 16135815, 15383283, 20068231, ...16456540
S863 Phosphorylation HPRD 20068231
S866 Phosphorylation HPRD 20068231
S867 Phosphorylation HPRD 19413330, 16964243, 16135815, ...15383283, 18669648, 16456540, 20068231
S867 Phosphorylation Q16539 (MAPK14) HPRD 19413330, 16964243, 16135815, ...15383283, 18669648, 16456540, 20068231
S1329 Phosphorylation HPRD 20068231
S1330 Phosphorylation HPRD 18669648
Y1357 Phosphorylation PRO 18765637
Y1357 Phosphorylation PR:P00519-1 (hABL1/iso:1) PRO 18765637
Site PTM Type PTM Enzyme Score Source PMID
T24 Phosphorylation HPRD 16135815, 15383283
S214 Phosphorylation HPRD 17322306, 19651622, 18669648, ...20068231
S274 Phosphorylation HPRD 20068231
T282 Phosphorylation HPRD 20068231
S284 Phosphorylation HPRD 20068231
S287 Phosphorylation HPRD 20068231
S288 Phosphorylation HPRD 20068231
S429 Phosphorylation HPRD 20068231
S505 Phosphorylation HPRD 16135815, 15383283, 16456540
S505 Phosphorylation Q16539 (MAPK14) HPRD 16135815, 15383283, 16456540
S543 Phosphorylation HPRD 16135815, 15383283, 16456540
S543 Phosphorylation Q16539 (MAPK14) HPRD 16135815, 15383283, 16456540
S551 Phosphorylation HPRD 19413330, 18767875, 18669648, ...20068231
S694 Phosphorylation HPRD 20068231
S728 Phosphorylation HPRD 18669648
S857 Phosphorylation HPRD 19413330, 16964243, 16135815, ...15302935, 19651622, 18669648, 15383283, 20068231
S857 Phosphorylation O14920 (IKBKB) HPRD 19413330, 16964243, 16135815, ...15302935, 19651622, 18669648, 15383283, 20068231
S857 Phosphorylation O15111 (CHUK) HPRD 19413330, 16964243, 16135815, ...15302935, 19651622, 18669648, 15383283, 20068231
S860 Phosphorylation HPRD 16135815, 15383283, 20068231, ...16456540
S860 Phosphorylation Q16539 (MAPK14) HPRD 16135815, 15383283, 20068231, ...16456540
S863 Phosphorylation HPRD 20068231
S866 Phosphorylation HPRD 20068231
S867 Phosphorylation HPRD 19413330, 16964243, 16135815, ...15383283, 18669648, 16456540, 20068231
S867 Phosphorylation Q16539 (MAPK14) HPRD 19413330, 16964243, 16135815, ...15383283, 18669648, 16456540, 20068231
S1325 Phosphorylation HPRD 20068231
S1326 Phosphorylation HPRD 18669648


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048530 (hNCOA3/Phos:4) pS857 PRO
PR:000027692 (hNCOA3/iso:1/Phos:1) pS101,pS102 PRO 18922467, 21577200
PR:000027694 (hNCOA3/iso:1/Phos:2) pS601 PR:P48730 (hCSNK1D) PRO 19339517
PR:000027696 (hNCOA3/iso:1/Phos:3) pY1357 PR:P00519-1 (hABL1/iso:1) PRO 18765637
PR:000027698 (hNCOA3/iso:1/Phos:4) pS857 PRO 15383283
PR:000027885 (hNCOA3/iso:1/Ac:1) acK619,acK620 PR:Q09472 (hEP300) PRO 10490106
PR:000027887 (hNCOA3/iso:1/Ac:2) acK687 PRO 19608861


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q9Y6Q9 (NCOA3) S102 O43791 (SPOP) unknown eFIP 21577200
Phosphorylation Q9Y6Q9 (NCOA3) S860 Q13618 (CUL3) increased_association eFIP 22147914


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000027692 (hNCOA3/iso:1/Phos:1) Interaction PR:O43791 (hSPOP) PRO 21577200
PR:000027696 (hNCOA3/iso:1/Phos:3) Interaction PR:000007204 (ESR1) PRO 18765637
PR:000027696 (hNCOA3/iso:1/Phos:3) Interaction PR:000027108 (h(CBP-p300)) PRO 18765637


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S32 N32 Biomuta DOID:4159 / skin cancer [ cosmic ]
S101 Y101 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
R251 H251 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T282 P282 Biomuta DOID:1319 / brain cancer [ cosmic ]
S288 F288 Biomuta DOID:4159 / skin cancer [ cosmic ]
S429 R429 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S543 P543 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S601 N601 Biomuta DOID:1319 / brain cancer [ cosmic ]
S640 F640 Biomuta DOID:4159 / skin cancer [ cosmic ]
S715 F715 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K723 R723 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S836 C836 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S836 Y836 Biomuta DOID:263 / kidney cancer [ icgc ]
R849 C849 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic, icgc ]
R849 H849 Biomuta DOID:363 / uterine cancer [ icgc ]
S863 F863 Biomuta DOID:1324 / lung cancer [ cosmic ]
S867 C867 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S867 G867 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
S917 T917 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
R951 I951 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1033 Y1033 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S1042 F1042 Biomuta [ cosmic ]
K1091 T1091 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
R1163 Q1163 Biomuta [ cosmic ]
R1171 K1171 Biomuta DOID:4159 / skin cancer [ cosmic ]
R1171 I1171 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R1188 Q1188 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S1326 G1326 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, cosmic ] DOID:1793 / pancreatic cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ cosmic ]
S1330 G1330 Biomuta DOID:4159 / skin cancer [ cosmic ]