iPTMnet Report for Q9Y6D6 (ARFGEF1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y6D6 / BIG1_HUMAN
Protein Name Brefeldin A-inhibited guanine nucleotide-exchange protein 1
Gene Name Name: ARFGEF1
Synonyms:ARFGEP1,BIG1;
Organism Homo sapiens (Human)

PRO ID PR:Q9Y6D6
DAG View
PRO Name brefeldin A-inhibited guanine nucleotide-exchange protein 1 (human)
Definition A brefeldin A-inhibited guanine nucleotide-exchange protein 1 that is encoded in the genome of human.
Short Label hARFGEF1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y6D6 (ARFGEF1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K23 Ubiquitination PhosphoSitePlus
S31 Phosphorylation PhosphoSitePlus
T48 Phosphorylation PhosphoSitePlus
S52 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 23186163
S63 Phosphorylation PhosphoSitePlus
S70 Phosphorylation PhosphoSitePlus
Y109 Phosphorylation PhosphoSitePlus
S234 Phosphorylation HPRD   PhosphoSitePlus 20068231
S237 Phosphorylation HPRD   PhosphoSitePlus 20068231
S243 Phosphorylation HPRD   PhosphoSitePlus 20068231
S258 Phosphorylation PhosphoSitePlus
T269 Phosphorylation PhosphoSitePlus
S286 Phosphorylation PhosphoSitePlus
S289 Phosphorylation PhosphoSitePlus
S290 Phosphorylation PhosphoSitePlus
S394 Phosphorylation HPRD   PhosphoSitePlus 18691976, 19664994
S396 Phosphorylation HPRD   PhosphoSitePlus 18691976
S397 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 23186163, 18691976
T400 Phosphorylation phospho.ELM 15302935
S403 Phosphorylation HPRD   PhosphoSitePlus 20058876
S410 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 23186163
K432 Acetylation PhosphoSitePlus
S595 Phosphorylation PhosphoSitePlus
S618 Phosphorylation PhosphoSitePlus
Y662 Phosphorylation PhosphoSitePlus
S664 Phosphorylation PhosphoSitePlus
S667 Phosphorylation PhosphoSitePlus
S672 Phosphorylation PhosphoSitePlus
K757 Ubiquitination PhosphoSitePlus
K796 Ubiquitination PhosphoSitePlus
K849 Acetylation PhosphoSitePlus
Y852 Phosphorylation PhosphoSitePlus
K863 Ubiquitination PhosphoSitePlus
Y869 Phosphorylation PhosphoSitePlus
S871 Phosphorylation PhosphoSitePlus
Y874 Phosphorylation PhosphoSitePlus
K880 Ubiquitination PhosphoSitePlus
S883 Phosphorylation P17612 (PRKACA) PhosphoSitePlus   RLIMS-P   Signor 16467138
T894 Phosphorylation PhosphoSitePlus
T1062 Phosphorylation PhosphoSitePlus
Y1068 Phosphorylation PhosphoSitePlus
T1072 Phosphorylation PhosphoSitePlus
S1079 Phosphorylation PhosphoSitePlus   UniProt 21406692
T1081 Phosphorylation PhosphoSitePlus
T1083 Phosphorylation PhosphoSitePlus
K1220 Ubiquitination PhosphoSitePlus
K1224 Ubiquitination PhosphoSitePlus
K1234 Ubiquitination PhosphoSitePlus
K1352 Ubiquitination PhosphoSitePlus
S1555 Phosphorylation PhosphoSitePlus
S1558 Phosphorylation PhosphoSitePlus
T1564 Phosphorylation PhosphoSitePlus
S1566 Phosphorylation PhosphoSitePlus
S1569 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...17081983, 18452278, 19651622, 18669648, 24275569, 18707149, 20068231
S1575 Phosphorylation PhosphoSitePlus
S1580 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18691976, 18669648
K1601 Ubiquitination PhosphoSitePlus
S1641 Phosphorylation PhosphoSitePlus
K1694 Ubiquitination PhosphoSitePlus
T1704 Phosphorylation PhosphoSitePlus
K1708 Acetylation PhosphoSitePlus
K1708 Ubiquitination PhosphoSitePlus
S1715 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S31 C31 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S52 N52 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
S70 L70 Biomuta DOID:4159 / skin cancer [ cosmic ]
T269 A269 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S290 T290 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S403 C403 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y852 H852 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S871 * Biomuta DOID:3571 / liver cancer [ cosmic ]
S883 L883 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K1234 N1234 Biomuta DOID:4159 / skin cancer [ cosmic ]
K1352 E1352 Biomuta DOID:1612 / breast cancer [ icgc ]
S1715 F1715 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]