iPTMnet Report for Q9Y696 (CLIC4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y696 / CLIC4_HUMAN
Protein Name Chloride intracellular channel protein 4
Gene Name Name: CLIC4
Organism Homo sapiens (Human)

PRO ID PR:Q9Y696
DAG View
PRO Name chloride intracellular channel protein 4 (human)
Definition A chloride intracellular channel protein 4 that is encoded in the genome of human.
Short Label hCLIC4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y696 (CLIC4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 21406692, 22223895
S4 Phosphorylation PhosphoSitePlus   UniProt 21406692
K11 Acetylation PhosphoSitePlus
K11 Sumoylation PhosphoSitePlus
K15 Ubiquitination PhosphoSitePlus
K62 Ubiquitination PhosphoSitePlus
K90 Ubiquitination PhosphoSitePlus
K103 Ubiquitination PhosphoSitePlus
K106 Ubiquitination PhosphoSitePlus
S108 Phosphorylation PhosphoSitePlus   RLIMS-P 30237421
K110 Ubiquitination PhosphoSitePlus
S126 Phosphorylation PhosphoSitePlus
K130 Acetylation PhosphoSitePlus   UniProt 19608861
K130 Ubiquitination PhosphoSitePlus
S132 Phosphorylation IEDB 35494241
R142 Methylation PhosphoSitePlus
K146 Ubiquitination PhosphoSitePlus
S157 Phosphorylation PhosphoSitePlus
S167 Phosphorylation PhosphoSitePlus
K177 Ubiquitination PhosphoSitePlus
K194 Ubiquitination PhosphoSitePlus
K199 Ubiquitination PhosphoSitePlus
K212 Ubiquitination PhosphoSitePlus
Y220 Phosphorylation PhosphoSitePlus
R227 Methylation PhosphoSitePlus
C234 S-Nitrosylation dbSNO 16648260, 22178444
S236 Phosphorylation PhosphoSitePlus
K238 Ubiquitination PhosphoSitePlus
S245 Phosphorylation PhosphoSitePlus
K249 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K103 E103 Biomuta DOID:363 / uterine cancer [ icgc ]
S132 * Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
K212 E212 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
R227 S227 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K238 T238 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S245 N245 Biomuta DOID:10534 / stomach cancer [ cosmic ]