iPTMnet Report for Q9Y490 (TLN1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y490 / TLN1_HUMAN
Protein Name Talin-1
Gene Name Name: TLN1
Synonyms:KIAA1027,TLN;
Organism Homo sapiens (Human)

PRO ID PR:Q9Y490
DAG View
PRO Name talin-1 (human)
Definition A talin-1 that is encoded in the genome of human.
Short Label hTLN1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y490 (TLN1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T16 Phosphorylation PhosphoSitePlus
S22 Phosphorylation PhosphoSitePlus
T23 Phosphorylation PhosphoSitePlus
Y26 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
C29 Methylation IEDB 31844290
C29 S-Nitrosylation dbSNO 2212679, 22126794
R35 Methylation PhosphoSitePlus
S45 Phosphorylation PhosphoSitePlus
K57 Acetylation PhosphoSitePlus
Y70 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
Y71 Phosphorylation PhosphoSitePlus
R74 Methylation PhosphoSitePlus
T78 Phosphorylation PhosphoSitePlus
Y81 Phosphorylation PhosphoSitePlus
K83 Ubiquitination PhosphoSitePlus
T99 Phosphorylation PhosphoSitePlus
S105 Phosphorylation PhosphoSitePlus
T114 Phosphorylation PhosphoSitePlus
T122 Phosphorylation PhosphoSitePlus
Y127 Phosphorylation PhosphoSitePlus
S128 Phosphorylation PhosphoSitePlus
K138 Ubiquitination PhosphoSitePlus
T142 Phosphorylation PhosphoSitePlus
T144 Phosphorylation IEDB   PhosphoSitePlus 35494241
R146 Methylation PhosphoSitePlus
K149 Ubiquitination PhosphoSitePlus
T150 Phosphorylation PhosphoSitePlus
K164 Ubiquitination PhosphoSitePlus
T167 O-Glycosylation GlyGen 30587575, 35138101, 28657654, ...34725712, 26853435, 33214551, 25367160, 33465208, 34019948, 32119511, 34229054
T167 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
T179 O-Glycosylation GlyGen 30587575, 35138101, 28657654, ...34725712, 26853435, 33214551, 25367160, 33465208, 34019948, 32119511, 34229054
Y199 Phosphorylation PhosphoSitePlus
K254 Ubiquitination PhosphoSitePlus
K256 Ubiquitination PhosphoSitePlus
K268 Ubiquitination PhosphoSitePlus
Y270 Phosphorylation PhosphoSitePlus
K284 Ubiquitination PhosphoSitePlus
C286 S-Nitrosylation dbSNO 2212679, 22126794
K295 Ubiquitination PhosphoSitePlus
K334 Ubiquitination PhosphoSitePlus
T354 Phosphorylation PhosphoSitePlus
K357 Ubiquitination PhosphoSitePlus
S405 Phosphorylation PhosphoSitePlus   UniProt 24275569
K406 Ubiquitination PhosphoSitePlus
S423 Phosphorylation PhosphoSitePlus
S425 Phosphorylation Q00535 (CDK5) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 24793790, 23186163, 17081983, ...19363486, 18669648, 31108958, 18088087, 19690332, 20068231
K428 Methylation PhosphoSitePlus
K428 Ubiquitination PhosphoSitePlus
S429 Phosphorylation PhosphoSitePlus
Y436 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
K441 Ubiquitination PhosphoSitePlus
S446 Phosphorylation PhosphoSitePlus
R482 Methylation PhosphoSitePlus
T568 Phosphorylation PhosphoSitePlus
Y570 Phosphorylation PhosphoSitePlus
T571 Phosphorylation PhosphoSitePlus
S604 Phosphorylation PhosphoSitePlus
S620 Phosphorylation PhosphoSitePlus
S625 Phosphorylation PhosphoSitePlus
S677 Phosphorylation PhosphoSitePlus
C719 Methylation IEDB 31844290
S729 Phosphorylation PhosphoSitePlus
S834 Phosphorylation PhosphoSitePlus
S858 Phosphorylation PhosphoSitePlus
K861 Ubiquitination PhosphoSitePlus
K869 Acetylation PhosphoSitePlus
K869 Ubiquitination PhosphoSitePlus
K875 Ubiquitination PhosphoSitePlus
R889 Methylation PhosphoSitePlus
R898 Methylation PhosphoSitePlus
T931 Phosphorylation PhosphoSitePlus
T941 Phosphorylation PhosphoSitePlus
S945 Phosphorylation PhosphoSitePlus
S955 Phosphorylation PhosphoSitePlus
S973 Phosphorylation PhosphoSitePlus
S979 Phosphorylation PhosphoSitePlus
S981 Phosphorylation PhosphoSitePlus
S992 Phosphorylation PhosphoSitePlus
T1010 Phosphorylation PhosphoSitePlus
S1016 Phosphorylation PhosphoSitePlus
S1021 Phosphorylation PhosphoSitePlus   UniProt 24275569
T1029 Phosphorylation PhosphoSitePlus
R1035 Methylation PhosphoSitePlus
S1055 Phosphorylation PhosphoSitePlus
Y1116 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
S1130 Phosphorylation PhosphoSitePlus
T1142 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1163 Phosphorylation PhosphoSitePlus
S1164 Phosphorylation PhosphoSitePlus
S1201 Phosphorylation PhosphoSitePlus   UniProt 24275569
K1221 Acetylation PhosphoSitePlus
S1225 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1227 Phosphorylation PhosphoSitePlus
S1260 Phosphorylation PhosphoSitePlus
T1263 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1271 Phosphorylation PhosphoSitePlus
S1311 Phosphorylation PhosphoSitePlus
S1323 Phosphorylation PhosphoSitePlus   UniProt 24275569
T1324 Phosphorylation PhosphoSitePlus
S1333 Phosphorylation PhosphoSitePlus
T1343 Phosphorylation PhosphoSitePlus
S1411 Phosphorylation PhosphoSitePlus
Y1445 Phosphorylation PhosphoSitePlus
S1508 Phosphorylation PhosphoSitePlus
S1528 Phosphorylation PhosphoSitePlus
S1535 Phosphorylation PhosphoSitePlus
K1541 Acetylation PhosphoSitePlus
K1541 Ubiquitination PhosphoSitePlus
K1544 Acetylation PhosphoSitePlus
K1544 Ubiquitination PhosphoSitePlus
S1589 Phosphorylation PhosphoSitePlus
T1616 Phosphorylation PhosphoSitePlus
S1641 Phosphorylation PhosphoSitePlus
S1643 Phosphorylation PhosphoSitePlus
S1670 Phosphorylation PhosphoSitePlus
S1679 Phosphorylation PhosphoSitePlus
S1725 Phosphorylation PhosphoSitePlus
S1732 Phosphorylation PhosphoSitePlus
Y1737 Phosphorylation PhosphoSitePlus
S1750 Phosphorylation PhosphoSitePlus
T1752 O-Glycosylation GlyGen 30587575, 35138101, 28657654, ...34725712, 26853435, 33214551, 25367160, 33465208, 34019948, 32119511, 34229054
T1767 Phosphorylation PhosphoSitePlus
Y1777 Phosphorylation PhosphoSitePlus
S1849 Phosphorylation PhosphoSitePlus   UniProt 24275569
T1855 Phosphorylation PhosphoSitePlus   UniProt 24275569
Y1893 Phosphorylation PhosphoSitePlus
S1898 Phosphorylation PhosphoSitePlus
S1914 Phosphorylation PhosphoSitePlus
K1917 Ubiquitination PhosphoSitePlus
C1939 S-Nitrosylation dbSNO 22178444
S1940 Phosphorylation PhosphoSitePlus
Y1945 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
T1946 Phosphorylation PhosphoSitePlus
K1947 Acetylation PhosphoSitePlus
K1948 Ubiquitination PhosphoSitePlus
K1960 Ubiquitination PhosphoSitePlus
S1962 Phosphorylation PhosphoSitePlus
T2009 Phosphorylation PhosphoSitePlus
K2021 Ubiquitination PhosphoSitePlus
K2024 Acetylation PhosphoSitePlus
T2030 Phosphorylation PhosphoSitePlus
K2031 Acetylation PhosphoSitePlus   UniProt 19608861
S2040 Phosphorylation PhosphoSitePlus   UniProt 21406692, 24275569
S2068 Phosphorylation PhosphoSitePlus
K2089 Acetylation PhosphoSitePlus
S2096 Phosphorylation PhosphoSitePlus
T2098 Phosphorylation PhosphoSitePlus
K2115 Acetylation PhosphoSitePlus   UniProt 19608861
K2115 Methylation PhosphoSitePlus
K2115 Ubiquitination PhosphoSitePlus
T2123 Phosphorylation PhosphoSitePlus
S2127 Phosphorylation PhosphoSitePlus
K2133 Acetylation PhosphoSitePlus
S2162 Phosphorylation PhosphoSitePlus
T2171 Phosphorylation PhosphoSitePlus
K2180 Ubiquitination PhosphoSitePlus
T2183 Phosphorylation PhosphoSitePlus
T2186 Phosphorylation PhosphoSitePlus
R2197 Methylation PhosphoSitePlus
Y2224 Phosphorylation PhosphoSitePlus
R2233 Methylation PhosphoSitePlus
Y2239 Phosphorylation PhosphoSitePlus
S2262 Phosphorylation PhosphoSitePlus
T2270 Phosphorylation PhosphoSitePlus
T2281 Phosphorylation PhosphoSitePlus
S2338 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S2351 Phosphorylation PhosphoSitePlus
K2361 Ubiquitination PhosphoSitePlus
S2390 Phosphorylation PhosphoSitePlus
T2404 Phosphorylation PhosphoSitePlus
S2426 Phosphorylation PhosphoSitePlus
S2427 Phosphorylation PhosphoSitePlus
C2442 Methylation IEDB 31844290
K2454 Methylation PhosphoSitePlus
Y2530 Phosphorylation PhosphoSitePlus
K2531 Ubiquitination PhosphoSitePlus
S2535 Phosphorylation PhosphoSitePlus
R2538 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T16 Phosphorylation HPRD 20068231
S22 Phosphorylation HPRD 20068231
T23 Phosphorylation HPRD 20068231
Y26 Phosphorylation HPRD 18083107
Y70 Phosphorylation HPRD 15592455, 19901323, 20068231
Y71 Phosphorylation HPRD 20068231
T167 Phosphorylation HPRD 18669648
S423 Phosphorylation HPRD 19651622, 17081983, 20068231
S425 Phosphorylation HPRD 18088087, 18452278, 19651622, ...18669648, 19415658, 20068231
Y436 Phosphorylation HPRD 18083107
S979 Phosphorylation HPRD 20068231
Y1116 Phosphorylation HPRD 18083107
T1616 Phosphorylation HPRD 20068231
Y1945 Phosphorylation HPRD 18083107
S2040 Phosphorylation HPRD 20166139
S2338 Phosphorylation HPRD 18669648
S2357 Phosphorylation HPRD 20068231
Y2530 Phosphorylation HPRD 19901323


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T16 M16 Biomuta DOID:363 / uterine cancer [ icgc ]
R35 Q35 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
Y71 * Biomuta DOID:4159 / skin cancer [ cosmic ]
T99 M99 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K164 E164 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K284 R284 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K406 M406 Biomuta DOID:263 / kidney cancer [ cosmic ]
S423 P423 Biomuta DOID:1612 / breast cancer [ cosmic ]
S429 L429 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
R898 C898 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S955 R955 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
R1035 W1035 Biomuta DOID:4159 / skin cancer [ cosmic ]
R1035 Q1035 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y1116 D1116 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y1116 F1116 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T1142 M1142 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1227 L1227 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ]
S1227 W1227 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1323 F1323 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K1544 N1544 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S1643 F1643 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1725 F1725 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1750 F1750 Biomuta DOID:4159 / skin cancer [ cosmic, icgc, tcga ]
S1849 F1849 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:4362 / cervical cancer [ cosmic ]
S1898 L1898 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
C1939 Y1939 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
K1960 M1960 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K2021 N2021 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T2098 M2098 Biomuta DOID:363 / uterine cancer [ icgc ]
S2162 F2162 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T2281 I2281 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
C2442 * Biomuta DOID:1319 / brain cancer [ cosmic ]
S2535 * Biomuta DOID:263 / kidney cancer [ cosmic ]
R2538 Q2538 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
R2538 * Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ]