iPTMnet Report for Q9Y478 (PRKAB1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y478 / AAKB1_HUMAN
Protein Name 5'-AMP-activated protein kinase subunit beta-1
Gene Name Name: PRKAB1
Synonyms:AMPK;
Organism Homo sapiens (Human)

PRO ID PR:Q9Y478
DAG View
PRO Name 5'-AMP-activated protein kinase subunit beta-1 (human)
Definition A 5'-AMP-activated protein kinase subunit beta-1 that is encoded in the genome of human.
Short Label hPRKAB1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y478 (PRKAB1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
G2 Myristoylation UniProt 21680840
T4 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18088087
S5 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18088087
S6 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18088087
T19 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 20068231, 19369195
S24 Phosphorylation Q13131 (PRKAA1) HPRD   phospho.ELM   PhosphoSitePlus 9305909, 19376078
S25 Phosphorylation PhosphoSitePlus
T28 Phosphorylation PhosphoSitePlus
K35 Ubiquitination PhosphoSitePlus
S40 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 23186163, 20068231, ...19369195
S49 Phosphorylation PhosphoSitePlus
K53 Ubiquitination PhosphoSitePlus
K57 Ubiquitination PhosphoSitePlus
K72 Ubiquitination PhosphoSitePlus
T80 Phosphorylation Q13131 (PRKAA1) PhosphoSitePlus 19376078
K89 Ubiquitination PhosphoSitePlus
Y92 Phosphorylation PhosphoSitePlus
S94 Phosphorylation PhosphoSitePlus
S96 Phosphorylation PhosphoSitePlus   UniProt 23186163, 19690332, 24275569
S101 Phosphorylation PhosphoSitePlus
K102 Ubiquitination PhosphoSitePlus
S108 Phosphorylation Q13131 (PRKAA1) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19651622, 18691976, 21406692, ...19376078, 18088087, 19369195, 20230923, 28924239, 9305909, 18669648, 24275569, 22363791, 20166139, 23186163, 17728241, 19690332, 20068231
S138 Phosphorylation PhosphoSitePlus
S144 Phosphorylation PhosphoSitePlus
T148 Phosphorylation Q13131 (PRKAA1) PhosphoSitePlus   RLIMS-P   UniProt 19369195, 26831516, 25792737
K157 Ubiquitination PhosphoSitePlus
T158 Phosphorylation Q13131 (PRKAA1) PhosphoSitePlus 19376078
S170 Phosphorylation PhosphoSitePlus
S174 Phosphorylation Q13131 (PRKAA1) PhosphoSitePlus 19376078
S177 Phosphorylation Q13131 (PRKAA1) PhosphoSitePlus 19376078
S180 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18691976, 18669648
S181 Phosphorylation HPRD   PhosphoSitePlus 18691976, 18669648
S182 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 9305909
Y187 Phosphorylation PhosphoSitePlus
K195 Ubiquitination PhosphoSitePlus
S252 Phosphorylation HPRD 18691976
T254 Phosphorylation PhosphoSitePlus
Y261 Phosphorylation PhosphoSitePlus
K268 Ubiquitination PhosphoSitePlus


Q9Y478 (PRKAB1) as PTM Enzyme



Substrate Site Score Source PMID
P14859 (POU2F1) S335 PhosphoSitePlus 25937278
P29474 (NOS3) S1177 Signor 11729179


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S24 T24 Biomuta DOID:1324 / lung cancer [ cosmic ]
K53 N53 Biomuta DOID:3571 / liver cancer [ cosmic ]
K72 E72 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S182 Y182 Biomuta [ cosmic ]
K195 R195 Biomuta DOID:1612 / breast cancer [ cosmic ]