iPTMnet Report for Q9Y3Q4 (HCN4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y3Q4 / HCN4_HUMAN
Protein Name Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Gene Name Name: HCN4
Organism Homo sapiens (Human)

PRO ID PR:Q9Y3Q4
DAG View
PRO Name potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (human)
Definition A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 that is encoded in the genome of human.
Short Label hHCN4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y3Q4 (HCN4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S14 Phosphorylation P17612 (PRKACA) neXtProt   PhosphoSitePlus 2071354
S67 Phosphorylation PhosphoSitePlus
S69 Phosphorylation PhosphoSitePlus
S99 Phosphorylation P17612 (PRKACA) neXtProt 2071354
S110 Phosphorylation P17612 (PRKACA) neXtProt 2071354
S117 Phosphorylation P17612 (PRKACA) neXtProt 2071354
S230 Phosphorylation PhosphoSitePlus
S236 Phosphorylation PhosphoSitePlus
Y531 Phosphorylation P12931 (SRC) PhosphoSitePlus   Signor 17977941
Y554 Phosphorylation PhosphoSitePlus
T650 Phosphorylation PhosphoSitePlus
S719 Phosphorylation P17612 (PRKACA) neXtProt 2071354
S831 Phosphorylation P17612 (PRKACA) neXtProt 2071354
S917 Phosphorylation P17612 (PRKACA) neXtProt 2071354
S921 Phosphorylation PhosphoSitePlus
S1005 Phosphorylation P17612 (PRKACA) neXtProt 2071354
S1011 Phosphorylation P17612 (PRKACA) neXtProt 2071354
S1015 Phosphorylation PhosphoSitePlus
T1020 Phosphorylation PhosphoSitePlus
S1026 Phosphorylation PhosphoSitePlus
S1051 Phosphorylation P17612 (PRKACA) neXtProt 2071354
T1071 Phosphorylation P17612 (PRKACA) neXtProt   PhosphoSitePlus 2071354
T1075 Phosphorylation PhosphoSitePlus
S1112 Phosphorylation P17612 (PRKACA) neXtProt 2071354
S1131 Phosphorylation P17612 (PRKACA) neXtProt 2071354
T1156 Phosphorylation P17612 (PRKACA) neXtProt 2071354
S1157 Phosphorylation P17612 (PRKACA) neXtProt 2071354
S1158 Phosphorylation P17612 (PRKACA) neXtProt 2071354
S1160 Phosphorylation P17612 (PRKACA) neXtProt 2071354


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S831 Y831 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1160 F1160 Biomuta DOID:5041 / esophageal cancer [ cosmic ]