iPTMnet Report for Q9Y297 (BTRC)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y297 / FBW1A_HUMAN
Protein Name F-box/WD repeat-containing protein 1A
Gene Name Name: BTRC
Synonyms:BTRCP,FBW1A,FBXW1A;
Organism Homo sapiens (Human)

PRO ID PR:Q9Y297
DAG View
PRO Name F-box/WD repeat-containing protein 1A (human)
Definition An F-box/WD repeat-containing protein 1A that is encoded in the genome of human.
Short Label hBTRC
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y297 (BTRC) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K11 Ubiquitination PhosphoSitePlus
K14 Ubiquitination PhosphoSitePlus
K73 Ubiquitination PhosphoSitePlus
S82 Phosphorylation PhosphoSitePlus
S127 Phosphorylation PhosphoSitePlus
C137 Methylation IEDB 31844290
S158 Phosphorylation PhosphoSitePlus   RLIMS-P 33676897
K315 Ubiquitination PhosphoSitePlus
K326 Ubiquitination PhosphoSitePlus
C383 Methylation IEDB 31844290
S412 Phosphorylation RLIMS-P 23071779
K527 Ubiquitination PhosphoSitePlus
S555 Phosphorylation PhosphoSitePlus
S597 Phosphorylation PhosphoSitePlus
T599 Phosphorylation PhosphoSitePlus
Y600 Phosphorylation PhosphoSitePlus
T601 Phosphorylation PhosphoSitePlus
Y602 Phosphorylation PhosphoSitePlus
S604 Phosphorylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O43312 (MTSS1) S322 Q9Y297 (BTRC) unknown eFIP 24318128
Phosphorylation P19838 (NFKB1) S932 Q9Y297 (BTRC) unknown eFIP 12482991
Phosphorylation P30291 (WEE1) S123 Q9Y297 (BTRC) increased_association eFIP 16085715
Phosphorylation P41002 (CCNF) S704 Q9Y297 (BTRC) inhibited_association eFIP 30257202
Phosphorylation P50539 (MXI1) S160 Q9Y297 (BTRC) unknown eFIP 29507620
Phosphorylation Q07820 (MCL1) S159 Q9Y297 (BTRC) unknown eFIP 24261825
Phosphorylation Q13651 (IL10RA) S323 Q9Y297 (BTRC) unknown eFIP 22087322
Phosphorylation Q15717 (ELAVL1) S304 Q9Y297 (BTRC) unknown eFIP 23115237


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000035772 (hCTNNB1/iso:1/Phos:3) Interaction PR:Q9Y297 (hBTRC) PRO 10074433
PR:000037190 (hCTNNB1/iso:1/Phos:7) increased Interaction PR:Q9Y297 (hBTRC) PRO 21152425
PR:000037515 (hCTNNB1/iso:1/Phos:11) increased Interaction PR:Q9Y297 (hBTRC) PRO 16996060, 21152425, 23071615


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K73 N73 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S158 F158 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S597 F597 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S604 A604 Biomuta DOID:1324 / lung cancer [ cosmic ]