iPTMnet Report for Q9Y286 (SIGLEC7)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y286 / SIGL7_HUMAN
Protein Name Sialic acid-binding Ig-like lectin 7 precursor
Gene Name Name: SIGLEC7
Synonyms:AIRM1;
Organism Homo sapiens (Human)

PRO ID PR:Q9Y286
DAG View
PRO Name sialic acid-binding Ig-like lectin 7 (human)
Definition A sialic acid-binding Ig-like lectin 7 that is encoded in the genome of human.
Short Label hSIGLEC7
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y286 (SIGLEC7) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N105 N-Glycosylation GlyGen   UniProt 16895906, 16623661
S349 Phosphorylation PhosphoSitePlus
T362 Phosphorylation PhosphoSitePlus
S404 Phosphorylation PhosphoSitePlus
S406 Phosphorylation PhosphoSitePlus
T411 Phosphorylation PhosphoSitePlus
S428 Phosphorylation PhosphoSitePlus
S429 Phosphorylation PhosphoSitePlus   UniProt 24275569
Y437 Phosphorylation PhosphoSitePlus
S441 Phosphorylation PhosphoSitePlus
Y460 Phosphorylation PhosphoSitePlus
S461 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S404 Phosphorylation HPRD 20166139
S406 Phosphorylation HPRD 20166139
Y437 Phosphorylation HPRD 19901323
Y460 Phosphorylation HPRD 19901323
Site PTM Type PTM Enzyme Score Source PMID
S311 Phosphorylation HPRD 20166139
S313 Phosphorylation HPRD 20166139
Y344 Phosphorylation HPRD 19901323
Y367 Phosphorylation HPRD 19901323


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
N105 S105 Biomuta DOID:4159 / skin cancer [ cosmic ]
N105 H105 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S311 * Biomuta DOID:1324 / lung cancer [ cosmic ]
T362 I362 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S404 * Biomuta DOID:1324 / lung cancer [ cosmic ]
T411 S411 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S428 F428 Biomuta DOID:4159 / skin cancer [ cosmic ]