iPTMnet Report for Q9Y253 (POLH)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y253 / POLH_HUMAN
Protein Name DNA polymerase eta
Gene Name Name: POLH
Synonyms:RAD30,RAD30A,XPV;
Organism Homo sapiens (Human)

PRO ID PR:Q9Y253
DAG View
PRO Name DNA polymerase eta (human)
Definition A DNA polymerase eta that is encoded in the genome of human.
Short Label hPOLH
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y253 (POLH) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K32 Ubiquitination PhosphoSitePlus
K70 Sumoylation PhosphoSitePlus
K70 Ubiquitination PhosphoSitePlus
K86 Acetylation PhosphoSitePlus
K91 Ubiquitination PhosphoSitePlus
K131 Sumoylation PhosphoSitePlus
K131 Ubiquitination PhosphoSitePlus
K163 Sumoylation PhosphoSitePlus
K224 Acetylation PhosphoSitePlus
K224 Sumoylation PhosphoSitePlus
K224 Ubiquitination PhosphoSitePlus
K231 Ubiquitination PhosphoSitePlus
S242 Phosphorylation PhosphoSitePlus
K311 Sumoylation PhosphoSitePlus
K311 Ubiquitination PhosphoSitePlus
K317 Acetylation PhosphoSitePlus
K323 Ubiquitination PhosphoSitePlus
K328 Sumoylation PhosphoSitePlus
S369 Phosphorylation PhosphoSitePlus
K376 Ubiquitination PhosphoSitePlus
S379 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S380 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T427 Phosphorylation PhosphoSitePlus
K453 Sumoylation PhosphoSitePlus
K453 Ubiquitination PhosphoSitePlus
T457 O-Glycosylation GlyGen 30059200, 32574038, 30620550, ...29208956, 35254053
S458 O-Glycosylation GlyGen 32574038
K462 Sumoylation PhosphoSitePlus
K462 Ubiquitination PhosphoSitePlus
K474 Sumoylation PhosphoSitePlus
K475 Sumoylation PhosphoSitePlus
K486 Sumoylation PhosphoSitePlus
K486 Ubiquitination PhosphoSitePlus
K494 Sumoylation PhosphoSitePlus
S510 Phosphorylation PhosphoSitePlus
S512 Phosphorylation PhosphoSitePlus
S514 Phosphorylation PhosphoSitePlus
K515 Sumoylation PhosphoSitePlus
K533 Sumoylation PhosphoSitePlus
K583 Sumoylation PhosphoSitePlus
S587 Phosphorylation PhosphoSitePlus
K589 Sumoylation PhosphoSitePlus
S601 Phosphorylation Q13535 (ATR) neXtProt   PhosphoSitePlus   Signor 21242293
T617 Phosphorylation PhosphoSitePlus
K619 Sumoylation PhosphoSitePlus
K619 Ubiquitination PhosphoSitePlus
K682 Sumoylation PhosphoSitePlus
K682 Ubiquitination PRO   PhosphoSitePlus   UniProt 20159558
K686 Ubiquitination PRO   PhosphoSitePlus   UniProt 20159558
S687 Phosphorylation PhosphoSitePlus
K694 Ubiquitination PRO   PhosphoSitePlus   UniProt 20159558
K709 Sumoylation PhosphoSitePlus
K709 Ubiquitination PRO   PhosphoSitePlus   UniProt 20159558
Site PTM Type PTM Enzyme Score Source PMID
S379 Phosphorylation HPRD 18669648, 17081983, 17924679
S380 Phosphorylation HPRD 18669648, 17081983, 19664995


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048845 (hPOLH/Ubiq:1) ubK682,ubK686,ubK694,ubK709 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K32 E32 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K376 E376 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S514 P514 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
K515 N515 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K682 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S687 N687 Biomuta [ cosmic ]