iPTMnet Report for Q9Y243 (AKT3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y243 / AKT3_HUMAN
Protein Name RAC-gamma serine/threonine-protein kinase
Gene Name Name: AKT3
Synonyms:PKBG;
Organism Homo sapiens (Human)

PRO ID PR:Q9Y243
DAG View
PRO Name RAC-gamma serine/threonine-protein kinase (human)
Definition A RAC-gamma serine/threonine-protein kinase that is encoded in the genome of human.
Short Label hAKT3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y243 (AKT3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 19413330
S2 O-Glycosylation GlyGen 30379171, 18728220
K14 Ubiquitination PhosphoSitePlus
S34 Phosphorylation PhosphoSitePlus
S120 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332, 9512493
S123 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
K156 Ubiquitination PhosphoSitePlus
K181 Ubiquitination PhosphoSitePlus
S197 Phosphorylation PhosphoSitePlus
K273 Sumoylation PhosphoSitePlus
K273 Ubiquitination PhosphoSitePlus
K281 Ubiquitination PhosphoSitePlus
K286 Ubiquitination PhosphoSitePlus
T298 Phosphorylation PhosphoSitePlus
T302 Phosphorylation PhosphoSitePlus
T305 Phosphorylation Q15118 (PDK1) , O15530 (PDPK1) , Q05513 (PRKCZ) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 9512493, 10491192, 33833996, ...11387345, 27026523
T309 Phosphorylation PhosphoSitePlus
Y312 Phosphorylation PhosphoSitePlus
Y323 Phosphorylation PhosphoSitePlus
T432 Phosphorylation PhosphoSitePlus
Y434 Phosphorylation PhosphoSitePlus
T440 Phosphorylation PhosphoSitePlus
T447 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 9512493, 24275569
S472 Phosphorylation Q05513 (PRKCZ) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   UniProt 9512493, 10491192, 29038347, ...12162751, 11387345, 27026523, 10908564
Y473 Phosphorylation PhosphoSitePlus
S474 Phosphorylation PhosphoSitePlus
S476 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S120 Phosphorylation Q15118 (PDK1) HPRD 9512493
S123 Phosphorylation HPRD 17525332
T305 Phosphorylation Q05513 (PRKCZ) , O15530 (PDPK1) HPRD 12162751, 9512493
S472 Phosphorylation Q05655 (PRKCD) HPRD 11723139, 12162751
Site PTM Type PTM Enzyme Score Source PMID
S120 Phosphorylation Q15118 (PDK1) HPRD 9512493
S123 Phosphorylation HPRD 17525332
T305 Phosphorylation Q05513 (PRKCZ) , O15530 (PDPK1) HPRD 12162751, 9512493


Q9Y243 (AKT3) as PTM Enzyme



Substrate Site Score Source PMID
O15111 (CHUK) T23 Signor 19609947
O15119 (TBX3) S719 PhosphoSitePlus   Signor 25595898
O43524 (FOXO3) T32 Signor 19188143
O43524 (FOXO3) S253 Signor 19188143
O43524 (FOXO3) S315 Signor 19188143
P04792 (HSPB1) S82 Signor 19593530
P15056 (BRAF) S364 Signor 10869359
P15056 (BRAF) S365 neXtProt   PhosphoSitePlus 18451171
P15056 (BRAF) S428 Signor 10869359
P15056 (BRAF) S429 neXtProt   PhosphoSitePlus 18451171
P16220 (CREB1) S119 Signor 9829964
P29474 (NOS3) S615 Signor 24379783
P49841 (GSK3B) S9 Signor 23552696
P55211 (CASP9) S196 Signor 9812896
Q01860 (POU5F1) T235 Signor 23041284
Q13043 (STK4) T387 Signor 23431053
Q13188 (STK3) T117 Signor 20231902
Q92934 (BAD) S99 Signor 10949026
Q92934 (BAD) S118 Signor 10949026
Q96ST2 (IWS1) S720 Signor 24462114
Q96ST2 (IWS1) T721 Signor 24462114
Q9UKV8 (AGO2) S387 PhosphoSitePlus   Signor 18476811, 23603119


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000046301 (hAKT3/Phos:1) pS472 PRO
PR:000046302 (hAKT3/Phos:2) pT305 PRO
PR:000046303 (hAKT3/Phos:3) pT305,pS472 PRO