iPTMnet Report for Q9UQD0 (SCN8A)
Protein Information
UniProt AC / UniProt ID | Q9UQD0 / SCN8A_HUMAN |
Protein Name | Sodium channel protein type 8 subunit alpha |
Gene Name | Name: SCN8A Synonyms:MED; |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q9UQD0 |
PRO Name | sodium channel protein type 8 subunit alpha (human) |
Definition | A sodium channel protein type 8 subunit alpha that is encoded in the genome of human. |
Short Label | hSCN8A |
Category | organism-gene |
Q9UQD0 (SCN8A) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S13 | Phosphorylation | score1 | PhosphoSitePlus | |||
S21 | Phosphorylation | score1 | PhosphoSitePlus | |||
N289 | N-Glycosylation | score2 | UniProt | 36823201 | ||
N295 | N-Glycosylation | score3 | UniProt | 36696443, 36823201 | ||
N308 | N-Glycosylation | score3 | UniProt | 36696443, 36823201 | ||
N326 | N-Glycosylation | score3 | UniProt | 36696443, 36823201 | ||
S477 | Phosphorylation | score1 | PhosphoSitePlus | |||
S478 | Phosphorylation | score1 | PhosphoSitePlus | |||
S481 | Phosphorylation | score1 | PhosphoSitePlus | |||
K509 | Methylation | score1 | PhosphoSitePlus | |||
S541 | Phosphorylation | score1 | PhosphoSitePlus | |||
S546 | Phosphorylation | score1 | PhosphoSitePlus | |||
S553 | Phosphorylation | Q16539 (MAPK14) | score2 | neXtProt | 16014723 | |
S561 | Phosphorylation | score1 | PhosphoSitePlus | |||
S641 | Phosphorylation | score1 | PhosphoSitePlus | |||
T642 | Phosphorylation | score1 | PhosphoSitePlus | |||
S684 | Phosphorylation | score1 | PhosphoSitePlus | |||
S690 | Phosphorylation | score1 | PhosphoSitePlus | |||
N1358 | N-Glycosylation | score3 | UniProt | 36696443, 36823201 | ||
N1372 | N-Glycosylation | score3 | UniProt | 36696443, 36823201 | ||
K1487 | Acetylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S13 | N13 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
N326 | S326 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
S478 | F478 | Biomuta | [ cosmic ] | |
S553 | L553 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] | |
T642 | M642 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
S684 | F684 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
S690 | F690 | Biomuta | DOID:4159 / skin cancer [ cosmic ] |