iPTMnet Report for Q9UPP1 (PHF8)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UPP1 / PHF8_HUMAN
Protein Name Histone lysine demethylase PHF8
Gene Name Name: PHF8
Synonyms:KIAA1111,ZNF422;
Organism Homo sapiens (Human)

PRO ID PR:Q9UPP1
DAG View
PRO Name histone lysine demethylase PHF8 (human)
Definition A histone lysine demethylase PHF8 that is encoded in the genome of human.
Short Label hPHF8
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UPP1 (PHF8) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T22 Phosphorylation PhosphoSitePlus
T23 Phosphorylation PhosphoSitePlus
K36 Ubiquitination PhosphoSitePlus
S69 Phosphorylation neXtProt   PhosphoSitePlus   UniProt 20622854
S69 Phosphorylation P06493 (CDK1) PhosphoSitePlus 20622854
S104 Phosphorylation PhosphoSitePlus
S105 Phosphorylation PhosphoSitePlus
K117 Ubiquitination PhosphoSitePlus
S120 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 20622854, 15302935
S120 Phosphorylation P06493 (CDK1) PhosphoSitePlus 20622854
T122 Phosphorylation PhosphoSitePlus
K166 Ubiquitination PhosphoSitePlus
S175 Phosphorylation PhosphoSitePlus
K191 Ubiquitination PhosphoSitePlus
C204 Methylation IEDB 31844290
K207 Ubiquitination PhosphoSitePlus
K213 Ubiquitination PhosphoSitePlus
Y214 Phosphorylation PhosphoSitePlus
Y215 Phosphorylation PhosphoSitePlus
Y216 Phosphorylation PhosphoSitePlus
K219 Acetylation PhosphoSitePlus
K219 Ubiquitination PhosphoSitePlus
K244 Methylation PhosphoSitePlus
K248 Ubiquitination PhosphoSitePlus
T359 Phosphorylation PhosphoSitePlus
S373 Phosphorylation PhosphoSitePlus
Y383 Phosphorylation PhosphoSitePlus
K446 Ubiquitination PhosphoSitePlus
K467 Ubiquitination PhosphoSitePlus
K486 Ubiquitination PhosphoSitePlus
S501 O-Glycosylation GlyGen 30379171, 28510447, 35254053
S522 Phosphorylation PhosphoSitePlus
K527 Ubiquitination PhosphoSitePlus
K545 Ubiquitination PhosphoSitePlus
K570 Ubiquitination PhosphoSitePlus
K576 Ubiquitination PhosphoSitePlus
T614 Phosphorylation PhosphoSitePlus
S651 Phosphorylation PhosphoSitePlus   UniProt 19690332
K665 Ubiquitination PhosphoSitePlus
S685 Phosphorylation PhosphoSitePlus
Y704 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T705 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
T706 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
S722 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
K732 Ubiquitination PhosphoSitePlus
S802 Phosphorylation PhosphoSitePlus
S804 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
S807 Phosphorylation PhosphoSitePlus
S826 Phosphorylation PhosphoSitePlus
S834 Phosphorylation PhosphoSitePlus
Y852 Phosphorylation PhosphoSitePlus
S854 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 33010150, 18669648, 21406692, ...19690332
S857 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 23186163, 17081983, ...33010150, 18669648, 19690332, 20068231
S866 Phosphorylation PhosphoSitePlus
S874 Phosphorylation PhosphoSitePlus
S880 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...20068231
T886 Phosphorylation PhosphoSitePlus
T900 Phosphorylation PhosphoSitePlus
S904 Phosphorylation PhosphoSitePlus 21851590
S904 Phosphorylation O14757 (CHEK1) PhosphoSitePlus 21851590
T907 Phosphorylation PhosphoSitePlus
K915 Acetylation PhosphoSitePlus
K915 Ubiquitination PhosphoSitePlus
K923 Ubiquitination PhosphoSitePlus
T1007 Phosphorylation PhosphoSitePlus
S1021 Phosphorylation PhosphoSitePlus
S1024 Phosphorylation PhosphoSitePlus
K1043 Sumoylation PhosphoSitePlus
K1043 Ubiquitination PhosphoSitePlus
K1051 Sumoylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S84 Phosphorylation HPRD 15302935, 19691289
S486 Phosphorylation HPRD 20068231
Y668 Phosphorylation HPRD 18669648
T669 Phosphorylation HPRD 18669648
T670 Phosphorylation HPRD 18669648
S686 Phosphorylation HPRD 18669648
S768 Phosphorylation HPRD 19413330, 19664995, 20068231
S790 Phosphorylation HPRD 18452278
S818 Phosphorylation HPRD 18669648
S821 Phosphorylation HPRD 19413330, 17322306, 19664994, ...18452278, 19651622, 18669648, 19415658, 20068231
S844 Phosphorylation HPRD 19413330, 18669648, 19664994, ...20068231


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q9UPP1 (PHF8) S854 Q92547 (TOPBP1) inhibited_association eFIP 33952527


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T22 M22 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T23 K23 Biomuta DOID:3571 / liver cancer [ cosmic ]
S84 G84 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S104 F104 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S120 G120 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
T122 M122 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S175 L175 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T359 M359 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ]
S486 F486 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
S522 F522 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
T614 A614 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
T614 M614 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S904 Y904 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T907 K907 Biomuta DOID:3571 / liver cancer [ cosmic ]
S1021 P1021 Biomuta DOID:363 / uterine cancer [ icgc ]
K1051 R1051 Biomuta DOID:9256 / colorectal cancer [ cosmic ]