iPTMnet Report for Q9UPN7 (PPP6R1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UPN7 / PP6R1_HUMAN
Protein Name Serine/threonine-protein phosphatase 6 regulatory subunit 1
Gene Name Name: PPP6R1
Synonyms:KIAA1115,PP6R1,SAPS1;
Organism Homo sapiens (Human)

PRO ID PR:Q9UPN7
DAG View
PRO Name serine/threonine-protein phosphatase 6 regulatory subunit 1 (human)
Definition A serine/threonine-protein phosphatase 6 regulatory subunit 1 that is encoded in the genome of human.
Short Label hPPP6R1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UPN7 (PPP6R1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K38 Ubiquitination PhosphoSitePlus
K135 Ubiquitination PhosphoSitePlus
K190 Ubiquitination PhosphoSitePlus
K203 Ubiquitination PhosphoSitePlus
K461 Ubiquitination PhosphoSitePlus
Y463 Phosphorylation PhosphoSitePlus
T468 Phosphorylation PhosphoSitePlus
N477 N-Glycosylation GlyGen 24190977
K480 Ubiquitination PhosphoSitePlus
K492 Ubiquitination PhosphoSitePlus
K515 Ubiquitination PhosphoSitePlus
K516 Ubiquitination PhosphoSitePlus
T524 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19651622, 21406692
S529 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19651622, 23186163, 20068231, ...24275569
S530 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19651622, 23186163, 20068231
S531 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 20068231
S635 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 18452278, 21406692, ...19690332
S638 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19690332, 18669648, 21406692, ...18452278
S664 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 17081983
S667 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 17081983
T668 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 17081983
S670 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 17081983
S702 Phosphorylation PhosphoSitePlus   UniProt 19690332
S711 Phosphorylation PhosphoSitePlus
T725 Phosphorylation HPRD   phospho.ELM 18691976, 18669648
S726 Phosphorylation PhosphoSitePlus   UniProt 19690332
S759 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 18669648, 19690332
S770 Phosphorylation PhosphoSitePlus
T774 Phosphorylation PhosphoSitePlus
S800 O-Glycosylation GlyGen 23301498, 35132862
S813 O-Glycosylation GlyGen 31373491
S816 Phosphorylation PhosphoSitePlus
S817 Phosphorylation PhosphoSitePlus
S846 Phosphorylation IEDB 27920218
T862 Phosphorylation PhosphoSitePlus
S877 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K190 T190 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K461 * Biomuta DOID:1324 / lung cancer [ cosmic ]
K492 M492 Biomuta DOID:3571 / liver cancer [ cosmic ]
S529 C529 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S531 N531 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S667 N667 Biomuta DOID:3571 / liver cancer [ cosmic ]
S817 F817 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]