iPTMnet Report for Q9UNE7 (STUB1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UNE7 / CHIP_HUMAN
Protein Name E3 ubiquitin-protein ligase CHIP
Gene Name Name: STUB1
Synonyms:CHIP;ORFNames:PP1131;
Organism Homo sapiens (Human)

PRO ID PR:Q9UNE7
DAG View
PRO Name E3 ubiquitin-protein ligase CHIP (human)
Definition An E3 ubiquitin-protein ligase CHIP that is encoded in the genome of human.
Short Label hSTUB1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UNE7 (STUB1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K2 Methylation PhosphoSitePlus
K2 Ubiquitination UniProt 23560854
S19 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 17287340, ...16964243, 15302935, 18669648, 24275569, 23186163, 19690332, 20068231, 17081983
K22 Ubiquitination PhosphoSitePlus   UniProt 18042044
S23 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...15302935, 18669648, 16964243
S25 Phosphorylation PhosphoSitePlus   UniProt 23186163
K30 Sumoylation PhosphoSitePlus
K30 Ubiquitination PhosphoSitePlus
R35 Methylation PhosphoSitePlus
K41 Methylation PhosphoSitePlus
K41 Sumoylation PhosphoSitePlus
K41 Ubiquitination PhosphoSitePlus
C48 Methylation IEDB 31844290
C48 S-Nitrosylation dbSNO 26338901
Y49 Phosphorylation PhosphoSitePlus
C69 Methylation IEDB 31844290
K72 Methylation PhosphoSitePlus
K125 Sumoylation PhosphoSitePlus
K125 Ubiquitination PhosphoSitePlus
S137 Phosphorylation PhosphoSitePlus
S149 Phosphorylation PhosphoSitePlus   UniProt 23186163
C180 S-Nitrosylation dbSNO 26338901
C199 S-Nitrosylation dbSNO 19483679
K203 Sumoylation PhosphoSitePlus
K203 Ubiquitination PhosphoSitePlus
Y207 Phosphorylation PhosphoSitePlus
K221 Ubiquitination PhosphoSitePlus   UniProt 18042044
K255 Sumoylation PhosphoSitePlus
K255 Ubiquitination PhosphoSitePlus   UniProt 18042044
T271 Phosphorylation PhosphoSitePlus
S273 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
T276 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
Site PTM Type PTM Enzyme Score Source PMID
S19 Phosphorylation HPRD 19413330, 18691976, 17287340, ...16964243, 20230923, 18767875, 15302935, 19664995, 18452278, 19651622, 18669648, 20166139, 19415658, 20068231
S23 Phosphorylation HPRD 19413330, 18691976, 16964243, ...20230923, 18767875, 15302935, 19651622, 18669648, 20166139, 19415658, 20068231
S25 Phosphorylation HPRD 19413330, 19651622, 20230923
T271 Phosphorylation HPRD 20068231
S273 Phosphorylation HPRD 18669648, 20068231
T276 Phosphorylation HPRD 17525332


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K22 M22 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K125 E125 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S149 N149 Biomuta DOID:10283 / prostate cancer [ icgc ]