iPTMnet Report for Q9UN86 (G3BP2)
Protein Information
| UniProt AC / UniProt ID | Q9UN86 / G3BP2_HUMAN |
| Protein Name | Ras GTPase-activating protein-binding protein 2 |
| Gene Name | Name: G3BP2 Synonyms:KIAA0660; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q9UN86 |
| PRO Name | Ras GTPase-activating protein-binding protein 2 (human) |
| Definition | A Ras GTPase-activating protein-binding protein 2 that is encoded in the genome of human. |
| Short Label | hG3BP2 |
| Category | organism-gene |
Q9UN86 (G3BP2) as Substrate
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| K5 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S7 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K25 | Ubiquitination | score1 | PhosphoSitePlus | |||
| R32 | Methylation | score1 | PhosphoSitePlus | |||
| S48 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K50 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y56 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K64 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S67 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K76 | Acetylation | score1 | PhosphoSitePlus | |||
| K76 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K107 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T111 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K123 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S141 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18691976, 21406692, 17081983, ... | ||
| S149 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18691976, 21406692, 17081983, ... | ||
| S163 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y175 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y176 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T206 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S225 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18669648 | ||
| T226 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus RLIMS-P | 18669648, 35589951 | ||
| T227 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648, 23186163, 19690332 | ||
| S235 | O-Glycosylation | score1 | GlyGen | 33214551, 35138101, 35254053, ... | ||
| S235 | Phosphorylation | score2 | phospho.ELM UniProt | 18669648 | ||
| S245 | O-Glycosylation | score1 | GlyGen | 33214551, 35138101, 35254053, ... | ||
| K281 | Sumoylation | score1 | PhosphoSitePlus | |||
| S353 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T364 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K370 | Acetylation | score1 | PhosphoSitePlus | |||
| K370 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K392 | Ubiquitination | score1 | PhosphoSitePlus | |||
| R418 | Methylation | score1 | PhosphoSitePlus | |||
| R432 | Methylation | score1 | PhosphoSitePlus | |||
| R438 | Methylation | score1 | PhosphoSitePlus | |||
| R447 | Methylation | score1 | PhosphoSitePlus | |||
| R452 | Methylation | score1 | PhosphoSitePlus | |||
| R457 | Methylation | score2 | PhosphoSitePlus UniProt | 24129315 | ||
| S466 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| R468 | Methylation | score2 | PhosphoSitePlus UniProt | 24129315 | ||
| R476 | Methylation | score1 | PhosphoSitePlus |
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| T111 | Phosphorylation | score0 | HPRD | 20068231 | ||
| S141 | Phosphorylation | score0 | HPRD | 18691976, 17081983, 19664995, ... | ||
| S149 | Phosphorylation | score0 | HPRD | 18691976, 17081983, 19664995, ... | ||
| S173 | Phosphorylation | score0 | HPRD | 17081983 | ||
| Y175 | Phosphorylation | score0 | HPRD | 17081983 | ||
| S225 | Phosphorylation | score0 | HPRD | 19413330, 19664995 | ||
| T226 | Phosphorylation | score0 | HPRD | 19413330, 19664995 | ||
| T227 | Phosphorylation | score0 | HPRD | 19413330, 17322306, 18491316, ... |
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| T111 | Phosphorylation | score0 | HPRD | 20068231 | ||
| S141 | Phosphorylation | score2 | HPRD phospho.ELM | 18691976, 17081983, 19664995, ... | ||
| S149 | Phosphorylation | score2 | HPRD phospho.ELM | 18691976, 17081983, 19664995, ... | ||
| S173 | Phosphorylation | score0 | HPRD | 17081983 | ||
| Y175 | Phosphorylation | score0 | HPRD | 17081983 | ||
| S225 | Phosphorylation | score2 | HPRD phospho.ELM PhosphoSitePlus | 19413330, 17081983, 19664995, ... | ||
| T226 | Phosphorylation | score2 | HPRD phospho.ELM PhosphoSitePlus | 19413330, 18491316, 17081983, ... | ||
| T227 | Phosphorylation | score2 | HPRD phospho.ELM PhosphoSitePlus | 19413330, 17322306, 18491316, ... | ||
| S235 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 18669648, 17287340, 18452278 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| R32 | M32 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
| K107 | E107 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
| T111 | A111 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| K123 | T123 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| S173 | N173 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| S225 | C225 | Biomuta | DOID:5041 / esophageal cancer [ cosmic, icgc ] | |
| T364 | I364 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| K392 | T392 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| R418 | T418 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
| R432 | Q432 | Biomuta | DOID:1793 / pancreatic cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] | |
| R438 | H438 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ] | |
| R438 | C438 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
| R447 | C447 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| R452 | T452 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] |
DAG View