iPTMnet Report for Q9UMS4 (PRPF19)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UMS4 / PRP19_HUMAN
Protein Name Pre-mRNA-processing factor 19
Gene Name Name: PRPF19
Synonyms:NMP200;
Organism Homo sapiens (Human)

PRO ID PR:Q9UMS4
DAG View
PRO Name pre-mRNA-processing factor 19 (human)
Definition A pre-mRNA-processing factor 19 that is encoded in the genome of human.
Short Label hPRPF19
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UMS4 (PRPF19) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 19413330, 22223895
S2 Phosphorylation PhosphoSitePlus
C16 Methylation IEDB 31844290
S18 Phosphorylation PhosphoSitePlus
K32 Ubiquitination PhosphoSitePlus
K56 Ubiquitination PhosphoSitePlus
K64 Ubiquitination PhosphoSitePlus
S67 Phosphorylation HPRD 20068231
C114 Methylation IEDB 31844290
K122 Acetylation PhosphoSitePlus   UniProt 19608861
K122 Ubiquitination PhosphoSitePlus
T133 O-Glycosylation GlyGen 23301498, 35008409, 33214551, ...32522876, 35138101, 34725712, 29351928, 34019948, 35083852, 32119511, 35289036, 28510447, 22121020, 22661428
S148 O-Glycosylation GlyGen 23301498, 35008409, 33214551, ...32522876, 35138101, 34725712, 29351928, 34019948, 35083852, 32119511, 35289036, 28510447, 22121020, 22661428
S149 O-Glycosylation GlyGen 23301498, 35008409, 33214551, ...32522876, 35138101, 34725712, 29351928, 34019948, 35083852, 32119511, 35289036, 28510447, 22121020, 22661428
S149 Phosphorylation PhosphoSitePlus
S152 O-Glycosylation GlyGen 23301498, 35008409, 33214551, ...32522876, 35138101, 34725712, 29351928, 34019948, 35083852, 32119511, 35289036, 28510447, 22121020, 22661428
T169 O-Glycosylation GlyGen 23301498, 35008409, 33214551, ...32522876, 35138101, 34725712, 29351928, 34019948, 35083852, 32119511, 35289036, 28510447, 22121020, 22661428
K179 Acetylation PhosphoSitePlus
K179 Ubiquitination PhosphoSitePlus
T184 Phosphorylation PhosphoSitePlus
T185 Phosphorylation PhosphoSitePlus
K192 Ubiquitination PhosphoSitePlus
T193 Phosphorylation PhosphoSitePlus
K200 Ubiquitination PhosphoSitePlus
K206 Acetylation PhosphoSitePlus
K206 Ubiquitination PhosphoSitePlus
K236 Ubiquitination PhosphoSitePlus
K244 Acetylation PhosphoSitePlus
K244 Ubiquitination PhosphoSitePlus
K251 Ubiquitination PhosphoSitePlus
T259 Phosphorylation HPRD   PhosphoSitePlus 18452278
K261 Acetylation PhosphoSitePlus   UniProt 19608861
K261 Ubiquitination PhosphoSitePlus
K266 Ubiquitination PhosphoSitePlus
S269 O-Glycosylation GlyGen 23301498, 35008409, 33214551, ...32522876, 35138101, 34725712, 29351928, 34019948, 35083852, 32119511, 35289036, 28510447, 22121020, 22661428
S281 O-Glycosylation GlyGen 23301498, 35008409, 33214551, ...32522876, 35138101, 34725712, 29351928, 34019948, 35083852, 32119511, 35289036, 28510447, 22121020, 22661428
S281 Phosphorylation PhosphoSitePlus
S283 Phosphorylation PhosphoSitePlus
S297 Phosphorylation PhosphoSitePlus
S307 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
T310 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S313 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
Y329 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
T342 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
C351 Methylation IEDB 31844290
K380 Ubiquitination PhosphoSitePlus
Y405 Phosphorylation PhosphoSitePlus
K428 Ubiquitination PhosphoSitePlus
K500 Ubiquitination PhosphoSitePlus
S503 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K56 R56 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S67 L67 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T193 N193 Biomuta DOID:3571 / liver cancer [ cosmic ]
S281 F281 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S307 I307 Biomuta [ cosmic ]
K380 * Biomuta DOID:1324 / lung cancer [ cosmic ]