iPTMnet Report for Q9UM47 (NOTCH3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UM47 / NOTC3_HUMAN
Protein Name Neurogenic locus notch homolog protein 3 precursor
Gene Name Name: NOTCH3
Organism Homo sapiens (Human)

PRO ID PR:Q9UM47
DAG View
PRO Name neurogenic locus notch homolog protein 3 (human)
Definition A neurogenic locus notch homolog protein 3 that is encoded in the genome of human.
Short Label hNOTCH3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UM47 (NOTCH3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S84 O-Glycosylation GlyGen 32574038, 29351928, 36067866, ...35289036, 35254053, 28657654
S84 Phosphorylation PhosphoSitePlus
S118 Phosphorylation PhosphoSitePlus
S125 Phosphorylation PhosphoSitePlus
S126 Phosphorylation PhosphoSitePlus
S135 Phosphorylation PhosphoSitePlus
T190 O-Glycosylation GlyGen 32574038, 29351928, 36067866, ...35289036, 35254053, 28657654
T211 Phosphorylation PhosphoSitePlus
T384 O-Glycosylation GlyGen 32574038, 29351928, 36067866, ...35289036, 35254053, 28657654
S414 O-Glycosylation GlyGen 30127001
T424 O-Glycosylation GlyGen 32574038, 29351928, 36067866, ...35289036, 35254053, 28657654
Y529 Phosphorylation PhosphoSitePlus
T575 O-Glycosylation GlyGen 32574038, 29351928, 36067866, ...35289036, 35254053, 28657654
S725 O-Glycosylation GlyGen 32574038, 29351928, 36067866, ...35289036, 35254053, 28657654
N851 N-Glycosylation GlyGen 23090970
T993 O-Glycosylation GlyGen 32574038, 29351928, 36067866, ...35289036, 35254053, 28657654
S1029 O-Glycosylation GlyGen 32574038, 29351928, 36067866, ...35289036, 35254053, 28657654
N1179 N-Glycosylation GlyGen 23090970, 24190977
Y1197 Phosphorylation PhosphoSitePlus
T1198 O-Glycosylation GlyGen 32574038, 29351928, 36067866, ...35289036, 35254053, 28657654
S1239 O-Glycosylation GlyGen 32574038, 29351928, 36067866, ...35289036, 35254053, 28657654
T1272 O-Glycosylation GlyGen 32574038, 29351928, 36067866, ...35289036, 35254053, 28657654
T1274 O-Glycosylation GlyGen 32574038, 29351928, 36067866, ...35289036, 35254053, 28657654
S1320 O-Glycosylation GlyGen 32574038, 29351928, 36067866, ...35289036, 35254053, 28657654
S1672 Phosphorylation PhosphoSitePlus
T1673 Phosphorylation PhosphoSitePlus
S1681 Phosphorylation PhosphoSitePlus
K1684 Ubiquitination PhosphoSitePlus
S1712 Phosphorylation PhosphoSitePlus
Y1849 Phosphorylation PhosphoSitePlus
T1908 Phosphorylation PhosphoSitePlus
K1971 Ubiquitination PhosphoSitePlus
K1989 Ubiquitination PhosphoSitePlus
S2032 Phosphorylation PhosphoSitePlus
K2069 Ubiquitination PhosphoSitePlus
R2174 Methylation PhosphoSitePlus   UniProt 24129315


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T384 M384 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T384 R384 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S414 F414 Biomuta DOID:4159 / skin cancer [ cosmic ]
T424 A424 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
T575 S575 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T575 M575 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y1197 * Biomuta DOID:263 / kidney cancer [ cosmic ]
T1274 N1274 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
T1274 I1274 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
T1908 K1908 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]
T1908 M1908 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ cosmic ]
S2032 R2032 Biomuta DOID:4159 / skin cancer [ cosmic ]
R2174 Q2174 Biomuta DOID:10534 / stomach cancer [ cosmic ]