iPTMnet Report for Q9UL18 (AGO1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UL18 / AGO1_HUMAN
Protein Name Protein argonaute-1
Gene Name Name: AGO1
Synonyms:EIF2C1;
Organism Homo sapiens (Human)

PRO ID PR:Q9UL18
DAG View
PRO Name protein argonaute-1 (human)
Definition A protein argonaute-1 that is encoded in the genome of human.
Short Label hAGO1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UL18 (AGO1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K246 Ubiquitination PhosphoSitePlus
K333 Ubiquitination PhosphoSitePlus
T335 Phosphorylation PhosphoSitePlus
Y336 Phosphorylation PhosphoSitePlus
K353 Ubiquitination PhosphoSitePlus
S360 Phosphorylation PhosphoSitePlus
K364 Ubiquitination PhosphoSitePlus
K382 Ubiquitination PhosphoSitePlus
K398 Ubiquitination PhosphoSitePlus
K438 Acetylation PhosphoSitePlus
K458 Ubiquitination PhosphoSitePlus
K477 Ubiquitination PhosphoSitePlus
K491 Ubiquitination PhosphoSitePlus
T509 Phosphorylation HPRD   PhosphoSitePlus 18452278
Y510 Phosphorylation HPRD   PhosphoSitePlus 18452278
S511 Phosphorylation HPRD   PhosphoSitePlus 18452278
T524 Phosphorylation PhosphoSitePlus
K531 Ubiquitination PhosphoSitePlus
K552 Ubiquitination PhosphoSitePlus
S621 Phosphorylation PhosphoSitePlus
T626 Phosphorylation PhosphoSitePlus
K653 Ubiquitination PhosphoSitePlus
K718 Ubiquitination PhosphoSitePlus
S822 Phosphorylation PhosphoSitePlus
S826 Phosphorylation PhosphoSitePlus
S829 Phosphorylation PhosphoSitePlus
T850 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S360 L360 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y510 H510 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T524 P524 Biomuta DOID:263 / kidney cancer [ cosmic ]
T524 M524 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
T626 A626 Biomuta DOID:3571 / liver cancer [ cosmic ]
S829 L829 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]