iPTMnet Report for Q9UK59 (DBR1)
Protein Information
UniProt AC / UniProt ID | Q9UK59 / DBR1_HUMAN |
Protein Name | Lariat debranching enzyme |
Gene Name | Name: DBR1 |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q9UK59 |
PRO Name | lariat debranching enzyme (human) |
Definition | A lariat debranching enzyme that is encoded in the genome of human. |
Short Label | hDBR1 |
Category | organism-gene |
Q9UK59 (DBR1) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S69 | Phosphorylation | score1 | PhosphoSitePlus | |||
K128 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
K186 | Ubiquitination | score1 | PhosphoSitePlus | |||
K240 | Ubiquitination | score1 | PhosphoSitePlus | |||
T245 | O-Glycosylation | score1 | GlyGen | 23301498, 30379171, 28510447 | ||
K250 | Ubiquitination | score1 | PhosphoSitePlus | |||
K256 | Ubiquitination | score1 | PhosphoSitePlus | |||
K330 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y396 | Phosphorylation | score1 | PhosphoSitePlus | |||
S464 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 24275569 | ||
S474 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648 | ||
S478 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648 | ||
S479 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648 | ||
S485 | Phosphorylation | score1 | PhosphoSitePlus | |||
K492 | Ubiquitination | score1 | PhosphoSitePlus | |||
S499 | Phosphorylation | score1 | PhosphoSitePlus | |||
S514 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 21406692, 23186163, 17081983, ... | ||
Y533 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
K330 | N330 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
K330 | Q330 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
S474 | C474 | Biomuta | DOID:9253 / gastrointestinal stromal tumor [ cosmic ] | |
S478 | Y478 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] |