iPTMnet Report for Q9UJU2 (LEF1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UJU2 / LEF1_HUMAN
Protein Name Lymphoid enhancer-binding factor 1
Gene Name Name: LEF1
Organism Homo sapiens (Human)

PRO ID PR:Q9UJU2
DAG View
PRO Name lymphoid enhancer-binding factor 1 (human)
Definition A lymphoid enhancer-binding factor 1 that is encoded in the genome of human.
Short Label hLEF1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UJU2 (LEF1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S5 Phosphorylation PhosphoSitePlus
K36 Ubiquitination PhosphoSitePlus
S42 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus   RLIMS-P 17113388
K54 Ubiquitination PhosphoSitePlus
S61 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus   RLIMS-P 17113388
S79 Phosphorylation PhosphoSitePlus
Y83 Phosphorylation PhosphoSitePlus
K86 Acetylation PhosphoSitePlus
K86 Ubiquitination PhosphoSitePlus
K95 Acetylation PhosphoSitePlus
K95 Ubiquitination PhosphoSitePlus
Y102 Phosphorylation PhosphoSitePlus
Y114 Phosphorylation PhosphoSitePlus
N128 N-Glycosylation GlyGen 29671580
S132 Phosphorylation Q9UBE8 (NLK) PhosphoSitePlus   UniProt 19690332, 22373574
T155 Phosphorylation Q9UBE8 (NLK) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 24019581, 12556497, 22373574
T159 Phosphorylation PhosphoSitePlus
Y160 Phosphorylation PhosphoSitePlus
S161 Phosphorylation PhosphoSitePlus
S166 Phosphorylation Q9UBE8 (NLK) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 24019581, 12556497, 22373574
T195 Phosphorylation PhosphoSitePlus
Y197 Phosphorylation PhosphoSitePlus
S200 Phosphorylation Q9UBE8 (NLK) PhosphoSitePlus 22373574
T208 Phosphorylation PhosphoSitePlus
R226 Methylation PhosphoSitePlus
S238 Phosphorylation PhosphoSitePlus
S240 Phosphorylation PhosphoSitePlus
R241 Methylation PhosphoSitePlus
T265 Phosphorylation Q9UBE8 (NLK) PhosphoSitePlus 22373574
K283 Ubiquitination PhosphoSitePlus
K295 Ubiquitination PhosphoSitePlus
K301 Ubiquitination PhosphoSitePlus
K311 Ubiquitination PhosphoSitePlus
K324 Ubiquitination PhosphoSitePlus
K347 Ubiquitination PhosphoSitePlus
Y348 Phosphorylation PhosphoSitePlus
Y349 Phosphorylation PhosphoSitePlus
Y363 Phosphorylation PhosphoSitePlus
S367 Phosphorylation PhosphoSitePlus
K382 Ubiquitination PhosphoSitePlus
S386 Phosphorylation PhosphoSitePlus
T390 Phosphorylation PhosphoSitePlus
R393 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
N128 N-Glycosylation PRO 29671580
T155 Phosphorylation Q9UBE8 (NLK) HPRD 12556497
S166 Phosphorylation Q9UBE8 (NLK) HPRD 12556497
Site PTM Type PTM Enzyme Score Source PMID
S200 Phosphorylation PhosphoSitePlus
T208 Phosphorylation PhosphoSitePlus
T237 Phosphorylation PhosphoSitePlus
K363 Acetylation PhosphoSitePlus
K363 Ubiquitination PhosphoSitePlus
S366 Phosphorylation PhosphoSitePlus
K373 Ubiquitination PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048184 (hLEF1/Phos:1) pT155,pS166 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P35222 (CTNNB1) S191 Q9UJU2 (LEF1) increased_association eFIP 26403202
Phosphorylation Q9UJU2 (LEF1) S61 P35222 (CTNNB1) decreased_association eFIP 17113388


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000037190 (hCTNNB1/iso:1/Phos:7) decreased Interaction PR:Q9UJU2 (hLEF1) PRO 23617586


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K54 T54 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S61 C61 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S61 P61 Biomuta DOID:4159 / skin cancer [ cosmic ]
K86 E86 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K95 R95 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y114 H114 Biomuta DOID:1319 / brain cancer [ cosmic ]
Y160 * Biomuta DOID:5041 / esophageal cancer [ cosmic ]
Y160 N160 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S238 A238 Biomuta DOID:1324 / lung cancer [ cosmic ]
R241 K241 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K311 N311 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ]
K324 N324 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S386 F386 Biomuta [ cosmic ]