iPTMnet Report for Q9UJ41 (RABGEF1)
Protein Information
UniProt AC / UniProt ID | Q9UJ41 / RABX5_HUMAN |
Protein Name | Rab5 GDP/GTP exchange factor |
Gene Name | Name: RABGEF1 Synonyms:RABEX5; |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q9UJ41 |
PRO Name | Rab5 GDP/GTP exchange factor (human) |
Definition | A Rab5 GDP/GTP exchange factor that is encoded in the genome of human. |
Short Label | hRABGEF1 |
Category | organism-gene |
Q9UJ41 (RABGEF1) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
K49 | Ubiquitination | score1 | PhosphoSitePlus | |||
K85 | Ubiquitination | score1 | PhosphoSitePlus | |||
K89 | Ubiquitination | score1 | PhosphoSitePlus | |||
K90 | Ubiquitination | score1 | PhosphoSitePlus | |||
K102 | Ubiquitination | score1 | PhosphoSitePlus | |||
K103 | Sumoylation | score1 | PhosphoSitePlus | |||
K103 | Ubiquitination | score1 | PhosphoSitePlus | |||
S106 | Phosphorylation | score1 | PhosphoSitePlus | |||
S108 | Phosphorylation | score1 | PhosphoSitePlus | |||
S113 | Phosphorylation | score1 | PhosphoSitePlus | |||
K115 | Sumoylation | score1 | PhosphoSitePlus | |||
K121 | Ubiquitination | score1 | PhosphoSitePlus | |||
S124 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 18669648, 23186163 | ||
T131 | Phosphorylation | score1 | PhosphoSitePlus | |||
S132 | Phosphorylation | score2 | IEDB PhosphoSitePlus UniProt | 30784271, 24275569 | ||
T135 | Phosphorylation | score1 | PhosphoSitePlus | |||
K140 | Ubiquitination | score1 | PhosphoSitePlus | |||
K147 | Ubiquitination | score1 | PhosphoSitePlus | |||
K151 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
K151 | Ubiquitination | score1 | PhosphoSitePlus | |||
K158 | Ubiquitination | score1 | PhosphoSitePlus | |||
K161 | Ubiquitination | score1 | PhosphoSitePlus | |||
K170 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
K170 | Ubiquitination | score1 | PhosphoSitePlus | |||
K206 | Ubiquitination | score1 | PhosphoSitePlus | |||
K213 | Acetylation | score1 | PhosphoSitePlus | |||
K221 | Ubiquitination | score1 | PhosphoSitePlus | |||
K234 | Ubiquitination | score1 | PhosphoSitePlus | |||
K240 | Ubiquitination | score1 | PhosphoSitePlus | |||
K281 | Ubiquitination | score1 | PhosphoSitePlus | |||
K287 | Ubiquitination | score1 | PhosphoSitePlus | |||
K293 | Ubiquitination | score1 | PhosphoSitePlus | |||
K303 | Sumoylation | score1 | PhosphoSitePlus | |||
K303 | Ubiquitination | score1 | PhosphoSitePlus | |||
S345 | Phosphorylation | score1 | PhosphoSitePlus | |||
S373 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 20068231 | ||
S377 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 20068231 | ||
S386 | Phosphorylation | score1 | PhosphoSitePlus | |||
T389 | Phosphorylation | score1 | PhosphoSitePlus | |||
S390 | Phosphorylation | score1 | PhosphoSitePlus | |||
K393 | Ubiquitination | score1 | PhosphoSitePlus | |||
S398 | Phosphorylation | score1 | PhosphoSitePlus | |||
S400 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
K408 | Ubiquitination | score1 | PhosphoSitePlus | |||
K412 | Ubiquitination | score1 | PhosphoSitePlus | |||
K436 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y456 | Phosphorylation | score1 | PhosphoSitePlus |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S124 | Phosphorylation | score0 | HPRD | 18691976, 18669648 | ||
S132 | Phosphorylation | score0 | HPRD | 18088087, 17081983, 20068231 | ||
T135 | Phosphorylation | score0 | HPRD | 20068231 | ||
S373 | Phosphorylation | score0 | HPRD | 20068231 | ||
S377 | Phosphorylation | score0 | HPRD | 20068231 | ||
Y384 | Phosphorylation | score0 | HPRD | 18691976, 18669648 | ||
S386 | Phosphorylation | score0 | HPRD | 18669648, 20068231 | ||
T389 | Phosphorylation | score0 | HPRD | 18691976, 18669648, 20068231 | ||
S390 | Phosphorylation | score0 | HPRD | 18669648, 20068231 | ||
S400 | Phosphorylation | score0 | HPRD | 19413330 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S108 | Y108 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] | |
S108 | F108 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
K115 | E115 | Biomuta | DOID:10283 / prostate cancer [ cosmic, icgc ] | |
S124 | T124 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
T131 | I131 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
T135 | A135 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
K206 | N206 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] | |
K287 | Q287 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
Y384 | H384 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] | |
Y384 | C384 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
K408 | T408 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
Y456 | C456 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] |