iPTMnet Report for Q9UIU6 (SIX4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UIU6 / SIX4_HUMAN
Protein Name Homeobox protein SIX4
Gene Name Name: SIX4
Organism Homo sapiens (Human)

PRO ID PR:Q9UIU6
DAG View
PRO Name homeobox protein SIX4 (human)
Definition A homeobox protein SIX4 that is encoded in the genome of human.
Short Label hSIX4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UIU6 (SIX4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 21406692
S2 Phosphorylation PhosphoSitePlus
S3 Phosphorylation PhosphoSitePlus
S5 Phosphorylation PhosphoSitePlus
K17 Sumoylation PhosphoSitePlus
S44 Phosphorylation PhosphoSitePlus
S147 Phosphorylation PhosphoSitePlus
Y162 Phosphorylation PhosphoSitePlus
R198 Methylation PhosphoSitePlus
R200 Methylation PhosphoSitePlus
S249 Phosphorylation PhosphoSitePlus
S286 Phosphorylation HPRD   PhosphoSitePlus 19651622
S426 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 32574038, 35254053, 34019948, 30059200, 35132862, 31492838, 30620550
T434 Phosphorylation PhosphoSitePlus
S437 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 32574038, 35254053, 34019948, 30059200, 35132862, 31492838, 30620550
S437 Phosphorylation PhosphoSitePlus
S439 Phosphorylation PhosphoSitePlus
S443 Phosphorylation PhosphoSitePlus
T451 Phosphorylation PhosphoSitePlus
K454 Sumoylation PhosphoSitePlus
S551 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 32574038, 35254053, 34019948, 30059200, 35132862, 31492838, 30620550
T556 O-Glycosylation GlyGen 32574038
K568 Sumoylation PhosphoSitePlus
S640 O-Glycosylation GlyGen 30620550
S640 Phosphorylation HPRD   PhosphoSitePlus   UniProt 17525332
S644 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 32574038, 35254053, 34019948, 30059200, 35132862, 31492838, 30620550
S649 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...30379171, 32574038, 35254053, 34019948, 30059200, 35132862, 31492838, 30620550


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S2 C2 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S439 I439 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S439 G439 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S443 L443 Biomuta DOID:4159 / skin cancer [ cosmic ]
T556 M556 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
S644 T644 Biomuta DOID:363 / uterine cancer [ icgc ]