iPTMnet Report for Q9UIQ6 (LNPEP)
Protein Information
UniProt AC / UniProt ID | Q9UIQ6 / LCAP_HUMAN |
Protein Name | Leucyl-cystinyl aminopeptidase |
Gene Name | Name: LNPEP Synonyms:OTASE; |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q9UIQ6 |
PRO Name | leucyl-cystinyl aminopeptidase (human) |
Definition | A leucyl-cystinyl aminopeptidase that is encoded in the genome of human. |
Short Label | hLNPEP |
Category | organism-gene |
Q9UIQ6 (LNPEP) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
M1 | Acetylation | score1 | UniProt | 22814378 | ||
S19 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y46 | Phosphorylation | score1 | PhosphoSitePlus | |||
S51 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y70 | Phosphorylation | score1 | PhosphoSitePlus | |||
S72 | Phosphorylation | score1 | PhosphoSitePlus | |||
S73 | Phosphorylation | score1 | PhosphoSitePlus | |||
K75 | Ubiquitination | score1 | PhosphoSitePlus | |||
S80 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648, 23186163 | ||
S91 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163, 24275569 | ||
T93 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y95 | Phosphorylation | score1 | PhosphoSitePlus | |||
C134 | Methylation | score1 | IEDB | 31844290 | ||
N145 | N-Glycosylation | score1 | GlyGen | 24190977 | ||
S147 | O-Glycosylation | score1 | GlyGen | 34019948, 35289036 | ||
K159 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y177 | Phosphorylation | score1 | PhosphoSitePlus | |||
N184 | N-Glycosylation | score2 | GlyGen UniProt | 23090970, 24190977, 19349973 | ||
N256 | N-Glycosylation | score1 | GlyGen | 24190977 | ||
K286 | Acetylation | score1 | IEDB | 34357683 | ||
K287 | Acetylation | score1 | IEDB | 34357683 | ||
K287 | Ubiquitination | score1 | PhosphoSitePlus | |||
S329 | Phosphorylation | score1 | PhosphoSitePlus | |||
K333 | Ubiquitination | score1 | PhosphoSitePlus | |||
K334 | Ubiquitination | score1 | PhosphoSitePlus | |||
N374 | N-Glycosylation | score1 | GlyGen | 24190977 | ||
N448 | N-Glycosylation | score2 | GlyGen UniProt | 24190977, 19349973 | ||
S506 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y508 | Phosphorylation | score1 | PhosphoSitePlus | |||
N525 | N-Glycosylation | score1 | GlyGen | 24190977 | ||
K608 | Ubiquitination | score1 | PhosphoSitePlus | |||
K626 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y665 | Phosphorylation | score1 | PhosphoSitePlus | |||
S666 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y668 | Phosphorylation | score1 | PhosphoSitePlus | |||
S670 | Phosphorylation | score1 | PhosphoSitePlus | |||
S672 | Phosphorylation | score1 | PhosphoSitePlus | |||
S678 | Phosphorylation | score1 | PhosphoSitePlus | |||
N682 | N-Glycosylation | score2 | GlyGen UniProt | 24190977, 19349973 | ||
K691 | Acetylation | score1 | PhosphoSitePlus | |||
Y784 | Phosphorylation | score1 | PhosphoSitePlus | |||
S789 | Phosphorylation | score1 | PhosphoSitePlus | |||
N831 | N-Glycosylation | score1 | GlyGen | 24190977 | ||
N834 | N-Glycosylation | score1 | GlyGen | 29741879, 24190977 | ||
N850 | N-Glycosylation | score2 | GlyGen UniProt | 29741879, 24190977, 19349973 | ||
S886 | Phosphorylation | score1 | PhosphoSitePlus | |||
R904 | Methylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
Y46 | H46 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ] | |
T93 | A93 | Biomuta | DOID:263 / kidney cancer [ cosmic, icgc ] | |
N145 | K145 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
S147 | P147 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
K159 | * | Biomuta | DOID:363 / uterine cancer [ cosmic ] | |
S329 | * | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
S506 | C506 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
N525 | H525 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
S678 | T678 | Biomuta | DOID:10534 / stomach cancer [ icgc ] | |
S789 | * | Biomuta | DOID:4362 / cervical cancer [ cosmic ] | |
R904 | Q904 | Biomuta | DOID:3571 / liver cancer [ cosmic ] |