iPTMnet Report for Q9UHV7 (MED13)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UHV7 / MED13_HUMAN
Protein Name Mediator of RNA polymerase II transcription subunit 13
Gene Name Name: MED13
Synonyms:ARC250,KIAA0593,THRAP1,TRAP240;
Organism Homo sapiens (Human)

PRO ID PR:Q9UHV7
DAG View
PRO Name mediator of RNA polymerase II transcription subunit 13 (human)
Definition A mediator of RNA polymerase II transcription subunit 13 that is encoded in the genome of human.
Short Label hMED13
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UHV7 (MED13) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R70 Methylation PhosphoSitePlus
S225 O-Glycosylation GlyGen 30379171, 33214551, 34725712, ...34019948
S227 O-Glycosylation GlyGen 30379171, 33214551, 34725712, ...34019948
T229 O-Glycosylation GlyGen 30379171, 33214551, 34725712, ...34019948
Y240 Phosphorylation PhosphoSitePlus
S243 Phosphorylation PhosphoSitePlus
T324 Phosphorylation PhosphoSitePlus
T326 Phosphorylation HPRD   PhosphoSitePlus 18691976, 18452278
T329 Phosphorylation HPRD 18691976
S330 Phosphorylation HPRD   PhosphoSitePlus 18452278
T336 Phosphorylation HPRD   PhosphoSitePlus 18691976
S349 Phosphorylation PhosphoSitePlus
K366 Acetylation PhosphoSitePlus
K366 Ubiquitination PhosphoSitePlus
Y394 Phosphorylation PhosphoSitePlus
S395 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18669648, 23186163
T474 Phosphorylation PhosphoSitePlus
S481 Phosphorylation HPRD   PhosphoSitePlus 18691976
S500 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 20068231
S504 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
T519 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S530 Phosphorylation PhosphoSitePlus
S537 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
S553 Phosphorylation PhosphoSitePlus
T554 Phosphorylation PhosphoSitePlus
S557 Phosphorylation PhosphoSitePlus
Y561 Phosphorylation PhosphoSitePlus
T565 Phosphorylation HPRD   PhosphoSitePlus 20068231
S572 Phosphorylation HPRD 20068231
S635 Phosphorylation PhosphoSitePlus
S687 Phosphorylation PhosphoSitePlus
K712 Acetylation PhosphoSitePlus
S749 Phosphorylation HPRD   PhosphoSitePlus   RLIMS-P 18691976, 33444446
K815 Ubiquitination PhosphoSitePlus
S823 Phosphorylation PhosphoSitePlus
S826 Phosphorylation PhosphoSitePlus   UniProt 23186163
T836 Phosphorylation HPRD   PhosphoSitePlus 20068231
S839 Phosphorylation PhosphoSitePlus
S848 Phosphorylation HPRD   PhosphoSitePlus 20068231
T863 Phosphorylation HPRD   PhosphoSitePlus 18691976
T867 Phosphorylation PhosphoSitePlus
S890 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 23186163, 17081983, ...20068231
K892 Ubiquitination PhosphoSitePlus
S894 Phosphorylation PhosphoSitePlus
T1006 Phosphorylation PhosphoSitePlus
T1011 Phosphorylation PhosphoSitePlus
T1014 Phosphorylation PhosphoSitePlus
R1022 Methylation PhosphoSitePlus
S1029 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 15302935, 20068231, ...24275569
S1033 Phosphorylation HPRD   PhosphoSitePlus 20068231
K1133 Sumoylation PhosphoSitePlus
S1138 Phosphorylation PhosphoSitePlus
K1157 Sumoylation PhosphoSitePlus
S1247 Phosphorylation PhosphoSitePlus
T1393 Phosphorylation PhosphoSitePlus
Y1396 Phosphorylation PhosphoSitePlus
T1421 Phosphorylation PhosphoSitePlus
S1423 Phosphorylation PhosphoSitePlus
K1448 Ubiquitination PhosphoSitePlus
Y1452 Phosphorylation HPRD   PhosphoSitePlus 20068231
T1634 Phosphorylation PhosphoSitePlus
S1683 Phosphorylation PhosphoSitePlus
T1684 Phosphorylation PhosphoSitePlus
S1686 Phosphorylation PhosphoSitePlus
Y1694 Phosphorylation PhosphoSitePlus
T1728 Phosphorylation HPRD 20068231
K1772 Ubiquitination PhosphoSitePlus
K1786 Ubiquitination PhosphoSitePlus
S1833 Phosphorylation PhosphoSitePlus
S1834 Phosphorylation PhosphoSitePlus
K1837 Acetylation PhosphoSitePlus
K1842 Acetylation PhosphoSitePlus
S1887 Phosphorylation PhosphoSitePlus
S1889 Phosphorylation PhosphoSitePlus
K1890 Ubiquitination PhosphoSitePlus
C1957 Methylation IEDB 31844290
S2018 Phosphorylation PhosphoSitePlus
S2022 Phosphorylation PhosphoSitePlus
S2026 Phosphorylation PhosphoSitePlus
S2042 Phosphorylation PhosphoSitePlus
S2048 Phosphorylation HPRD   PhosphoSitePlus 18691976, 18452278
T2049 Phosphorylation PhosphoSitePlus
S2070 Phosphorylation PhosphoSitePlus
T2071 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R70 Q70 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
T326 I326 Biomuta DOID:1319 / brain cancer [ cosmic ]
T474 I474 Biomuta [ cosmic ]
T554 I554 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S557 T557 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S826 G826 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T836 A836 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
S839 L839 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S848 F848 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1138 L1138 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T1421 I1421 Biomuta DOID:363 / uterine cancer [ icgc ]
T1634 M1634 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T1634 R1634 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
Y1694 C1694 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K1890 T1890 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
C1957 G1957 Biomuta DOID:1324 / lung cancer [ cosmic ]
S2022 Y2022 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
S2026 F2026 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S2042 N2042 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
S2070 A2070 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]