iPTMnet Report for Q9UHD8 (SEPTIN9)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UHD8 / SEPT9_HUMAN
Protein Name Septin-9
Gene Name Name: SEPTIN9
Synonyms:KIAA0991,MSF,SEPT9;
Organism Homo sapiens (Human)

PRO ID PR:Q9UHD8
DAG View
PRO Name septin-9 (human)
Definition A septin-9 that is encoded in the genome of human.
Short Label hSEPTIN9
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UHD8 (SEPTIN9) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
K2 Methylation PhosphoSitePlus
K3 Methylation PhosphoSitePlus
S6 Phosphorylation PhosphoSitePlus
R10 Methylation PhosphoSitePlus
T11 Phosphorylation PhosphoSitePlus
S12 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
S13 Phosphorylation PhosphoSitePlus
R15 Methylation PhosphoSitePlus
S22 Phosphorylation PhosphoSitePlus   UniProt 23186163
K28 Acetylation PhosphoSitePlus
K28 Methylation PhosphoSitePlus
K28 Ubiquitination PhosphoSitePlus
S30 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 16964243, ...18220336, 18669648, 19690332, 20068231
T38 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S41 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T42 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 16964243
R46 Methylation PhosphoSitePlus
T49 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 18220336
T55 O-Glycosylation GlyGen 23301498, 33214551, 30379171, ...34725712, 34019948, 25367160, 35254053, 35132862, 33465208, 34229054
S59 Phosphorylation PhosphoSitePlus
T60 Phosphorylation PhosphoSitePlus
K62 Acetylation PhosphoSitePlus
K62 Ubiquitination PhosphoSitePlus
S71 Phosphorylation PhosphoSitePlus
S80 Phosphorylation PhosphoSitePlus
S82 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17287340, 20068231
S85 Phosphorylation IEDB   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 16083285, 23186163, ...17081983, 32157095, 17287340, 20068231
S89 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17287340
S96 O-Glycosylation GlyGen 23301498, 33214551, 30379171, ...34725712, 34019948, 25367160, 35254053, 35132862, 33465208, 34229054
S96 Phosphorylation PhosphoSitePlus   UniProt 20068231
S111 Phosphorylation PhosphoSitePlus
S115 Phosphorylation PhosphoSitePlus
K141 Ubiquitination PhosphoSitePlus
T142 O-Glycosylation GlyGen 23301498, 33214551, 30379171, ...34725712, 34019948, 25367160, 35254053, 35132862, 33465208, 34229054
T142 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17287340, 23186163, 20068231
S160 Phosphorylation PhosphoSitePlus
S170 O-Glycosylation GlyGen 23301498, 33214551, 30379171, ...34725712, 34019948, 25367160, 35254053, 35132862, 33465208, 34229054
K186 Ubiquitination PhosphoSitePlus
S203 Phosphorylation PhosphoSitePlus
S211 Phosphorylation PhosphoSitePlus
S217 Phosphorylation PhosphoSitePlus
T235 Phosphorylation PhosphoSitePlus
S238 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T242 Phosphorylation PhosphoSitePlus
S247 O-Glycosylation GlyGen 23301498, 33214551, 30379171, ...34725712, 34019948, 25367160, 35254053, 35132862, 33465208, 34229054
S247 Phosphorylation PhosphoSitePlus
C248 S-Nitrosylation dbSNO 26338901
T255 Phosphorylation PhosphoSitePlus
K262 Ubiquitination PhosphoSitePlus
K271 Ubiquitination PhosphoSitePlus
Y278 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18083107, 19690332
S283 Phosphorylation PhosphoSitePlus
K291 Ubiquitination PhosphoSitePlus
T317 Phosphorylation PhosphoSitePlus
K320 Methylation PhosphoSitePlus
K320 Ubiquitination PhosphoSitePlus
K322 Methylation PhosphoSitePlus
K326 Ubiquitination PhosphoSitePlus
S327 Phosphorylation PhosphoSitePlus   UniProt 21406692
T331 Phosphorylation PhosphoSitePlus
S332 Phosphorylation PhosphoSitePlus   UniProt 23186163
K338 Ubiquitination PhosphoSitePlus
K343 Ubiquitination PhosphoSitePlus
K352 Acetylation PhosphoSitePlus
K352 Ubiquitination PhosphoSitePlus
K357 Ubiquitination PhosphoSitePlus
T363 Phosphorylation PhosphoSitePlus
K381 Ubiquitination PhosphoSitePlus
K389 Ubiquitination PhosphoSitePlus
K400 Ubiquitination PhosphoSitePlus
K431 Acetylation PhosphoSitePlus
K431 Ubiquitination PhosphoSitePlus
K435 Ubiquitination PhosphoSitePlus
K445 Ubiquitination PhosphoSitePlus
T448 Phosphorylation PhosphoSitePlus
K458 Ubiquitination PhosphoSitePlus
K476 Acetylation PhosphoSitePlus
K476 Ubiquitination PhosphoSitePlus
S482 Phosphorylation PhosphoSitePlus
R485 Methylation PhosphoSitePlus
K490 Ubiquitination PhosphoSitePlus
S502 Phosphorylation PhosphoSitePlus
Y506 Phosphorylation PhosphoSitePlus
K511 Acetylation PhosphoSitePlus
K511 Ubiquitination PhosphoSitePlus
K519 Ubiquitination PhosphoSitePlus
T543 Phosphorylation PhosphoSitePlus
K549 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S7 Phosphorylation PhosphoSitePlus
S12 Phosphorylation HPRD 18691976, 18491316, 16964243, ...19664994, 15302935, 19691289, 19664995, 19651622, 18669648, 18707149, 18452278, 20068231, 18212344
T20 Phosphorylation HPRD 18669648
S23 Phosphorylation HPRD 18669648, 19691289, 20068231, ...18452278
T24 Phosphorylation P06493 (CDK1) HPRD   PhosphoSitePlus 19413330, 16964243, 23990466, ...19691289, 18452278, 19664995, 18669648
T31 Phosphorylation HPRD 18669648, 18212344, 20068231
S62 Phosphorylation HPRD 19413330, 18691976, 20068231
S64 Phosphorylation HPRD 19413330, 19651622, 17287340, ...20166139, 20068231
S67 Phosphorylation HPRD 19413330, 17322306, 17287340, ...18767875, 18452278, 19651622, 20166139, 19415658, 20068231
S71 Phosphorylation HPRD 17287340
S78 Phosphorylation HPRD 20068231
T124 Phosphorylation HPRD 17287340, 20068231
S185 Phosphorylation HPRD 20068231
T217 Phosphorylation HPRD 20068231
S220 Phosphorylation HPRD 18669648
Y260 Phosphorylation HPRD 18083107
Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation PhosphoSitePlus
S23 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S6 Phosphorylation PhosphoSitePlus
K9 Methylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S2 W2 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ]
S6 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K9 R9 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R10 Q10 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:10534 / stomach cancer [ cosmic ]
T20 R20 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K28 R28 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T38 R38 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S59 Y59 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S59 A59 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S67 F67 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S71 * Biomuta DOID:10534 / stomach cancer [ cosmic ]
S78 * Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
S78 L78 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S85 F85 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S96 L96 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S96 * Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
S111 P111 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S115 L115 Biomuta DOID:4159 / skin cancer [ cosmic ]
T124 M124 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T142 M142 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S185 C185 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K186 Q186 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S203 C203 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S220 G220 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S238 G238 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S283 Y283 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K291 T291 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K381 R381 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
K400 N400 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K458 R458 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
R485 W485 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R485 Q485 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y506 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]