iPTMnet Report for Q9UH99 (SUN2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UH99 / SUN2_HUMAN
Protein Name SUN domain-containing protein 2
Gene Name Name: SUN2
Synonyms:FRIGG,KIAA0668,RAB5IP,UNC84B;
Organism Homo sapiens (Human)

PRO ID PR:Q9UH99
DAG View
PRO Name SUN domain-containing protein 2 (human)
Definition A SUN domain-containing protein 2 that is encoded in the genome of human.
Short Label hSUN2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UH99 (SUN2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T9 Phosphorylation PhosphoSitePlus   RLIMS-P 31515493
Y11 Phosphorylation PhosphoSitePlus
S12 Phosphorylation P17612 (PRKACA) , Q13535 (ATR) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 12239280, 18077418, 31515493
S19 Phosphorylation PhosphoSitePlus
S20 Phosphorylation PhosphoSitePlus
S21 Phosphorylation PhosphoSitePlus   RLIMS-P 31515493
S22 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S25 Phosphorylation PhosphoSitePlus
S26 Phosphorylation PhosphoSitePlus
S30 Phosphorylation PhosphoSitePlus
S32 Phosphorylation PhosphoSitePlus
T33 Phosphorylation PhosphoSitePlus
S38 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 23186163, 31515493, 19690332
T42 Phosphorylation PhosphoSitePlus
S54 Phosphorylation P17612 (PRKACA) IEDB   phospho.ELM   PhosphoSitePlus   UniProt 12239280, 17081983, 29786170, ...24275569, 32387766, 27869121
S63 Phosphorylation PhosphoSitePlus
S71 Phosphorylation PhosphoSitePlus
S73 Phosphorylation PhosphoSitePlus
S85 Phosphorylation PhosphoSitePlus
R105 Methylation PhosphoSitePlus
T107 Phosphorylation PhosphoSitePlus
S110 Phosphorylation PhosphoSitePlus
S112 Phosphorylation PhosphoSitePlus
S113 Phosphorylation PhosphoSitePlus
S116 Phosphorylation P17612 (PRKACA) phospho.ELM   PhosphoSitePlus   UniProt 12239280
T124 Phosphorylation PhosphoSitePlus
Y134 Phosphorylation PhosphoSitePlus
Y140 Phosphorylation PhosphoSitePlus
Y143 Phosphorylation PhosphoSitePlus
S267 Phosphorylation PhosphoSitePlus
K300 Ubiquitination PhosphoSitePlus
T328 Phosphorylation PhosphoSitePlus
K344 Ubiquitination PhosphoSitePlus
K375 Ubiquitination PhosphoSitePlus
S381 Phosphorylation PhosphoSitePlus
K392 Ubiquitination PhosphoSitePlus
K409 Ubiquitination PhosphoSitePlus
K491 Ubiquitination PhosphoSitePlus
K502 Ubiquitination PhosphoSitePlus
T514 Phosphorylation PhosphoSitePlus
K533 Ubiquitination PhosphoSitePlus
Y549 Phosphorylation PhosphoSitePlus
S634 O-Glycosylation GlyGen 34846842, 33214551, 35138101, ...30379171, 34725712, 30059200, 29351928, 34019948, 35289036, 35254053
N636 N-Glycosylation GlyGen   UniProt 29741879, 19159218, 24190977
S637 O-Glycosylation GlyGen 34846842, 33214551, 35138101, ...30379171, 34725712, 30059200, 29351928, 34019948, 35289036, 35254053
S640 O-Glycosylation GlyGen 34846842
S641 O-Glycosylation GlyGen 34846842, 33214551, 35138101, ...30379171, 34725712, 30059200, 29351928, 34019948, 35289036, 35254053
C705 Methylation IEDB 31844290
Site PTM Type PTM Enzyme Score Source PMID
T9 Phosphorylation HPRD 17081983
Y11 Phosphorylation HPRD 17081983
S12 Phosphorylation HPRD 12239280, 18077418
S19 Phosphorylation HPRD 17081983
S20 Phosphorylation HPRD 17081983
S21 Phosphorylation HPRD 17081983
S22 Phosphorylation HPRD 17081983
S25 Phosphorylation HPRD 17081983
S26 Phosphorylation HPRD 17081983
S30 Phosphorylation HPRD 17081983
S32 Phosphorylation HPRD 17081983
T33 Phosphorylation HPRD 17081983
S38 Phosphorylation HPRD 20068231
S54 Phosphorylation HPRD 12239280, 20058876, 14615979
T107 Phosphorylation HPRD 19651622
S110 Phosphorylation HPRD 19651622
S112 Phosphorylation HPRD 19651622, 14615979
S113 Phosphorylation HPRD 19651622
S116 Phosphorylation HPRD 19651622, 12239280, 14615979
T514 Phosphorylation HPRD 19413330
Site PTM Type PTM Enzyme Score Source PMID
T124 Phosphorylation PhosphoSitePlus
T152 Phosphorylation PhosphoSitePlus
T154 Phosphorylation PhosphoSitePlus


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:Q8WXH0-5 (hSYNE2/iso:5) Interaction PR:Q9UH99 (hSUN2) PRO 19933576


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S12 F12 Biomuta DOID:4159 / skin cancer [ cosmic ]
S30 G30 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T33 A33 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S116 R116 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y140 * Biomuta DOID:3571 / liver cancer [ cosmic ]
Y143 H143 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S267 L267 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T328 I328 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S381 F381 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ]