Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UGK8 / SRGEF_HUMAN
Protein Name Secretion-regulating guanine nucleotide exchange factor
Gene Name Name: SERGEF
Synonyms:DELGEF,GNEFR;
Organism Homo sapiens (Human)

PRO ID PR:Q9UGK8
DAG View
PRO Name secretion-regulating guanine nucleotide exchange factor (human)
Definition A secretion-regulating guanine nucleotide exchange factor that is encoded in the genome of human.
Short Label hSERGEF
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UGK8 (SERGEF) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K47 Ubiquitination PhosphoSitePlus
K201 Ubiquitination PhosphoSitePlus
K256 Ubiquitination PhosphoSitePlus
Y304 Phosphorylation PhosphoSitePlus
K308 Ubiquitination PhosphoSitePlus
Y416 Phosphorylation PhosphoSitePlus
S418 Phosphorylation PhosphoSitePlus
S427 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 23186163
Site PTM Type PTM Enzyme Score Source PMID
S427 Phosphorylation HPRD 17525332


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S418 F418 Biomuta DOID:3571 / liver cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]