iPTMnet Report Q9UGK3 STAP2

Protein Information

Cytoscape View

UniProt AC / UniProt ID	Q9UGK3 / STAP2_HUMAN
Protein Name	Signal-transducing adaptor protein 2
Gene Name	Name: STAP2 Synonyms:BKS;
Organism	Homo sapiens (Human)

PRO ID	PR:Q9UGK3 DAG View
PRO Name	signal-transducing adaptor protein 2 (human)
Definition	A signal-transducing adaptor protein 2 that is encoded in the genome of human.
Short Label	hSTAP2
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q9UGK3 (STAP2) as Substrate

Expanded View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	Y22	Phosphorylation	P12931 (SRC) , O60674 (JAK2)	score3	neXtProt phospho.ELM PhosphoSitePlus Signor UniProt	12540842
	C172	Methylation		score1	IEDB	31844290
	T191	Phosphorylation		score1	PhosphoSitePlus
	Y204	Phosphorylation		score1	PhosphoSitePlus
	Y250	Phosphorylation	Q13882 (PTK6) , P12931 (SRC) , O60674 (JAK2)	score4	neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	12540842, 19393627, 28478037, ...17368569
	Y256	Phosphorylation		score1	PhosphoSitePlus
	T282	Phosphorylation		score1	PhosphoSitePlus
	S289	Phosphorylation		score1	PhosphoSitePlus
	Y310	Phosphorylation	O60674 (JAK2)	score3	neXtProt phospho.ELM PhosphoSitePlus UniProt	12540842
	Y322	Phosphorylation	O60674 (JAK2) , P12931 (SRC)	score3	neXtProt phospho.ELM PhosphoSitePlus Signor UniProt	12540842
	K337	Ubiquitination		score1	PhosphoSitePlus
	T381	O-Glycosylation		score1	GlyGen	32574038
	T388	Phosphorylation		score1	PhosphoSitePlus

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	Y22	Phosphorylation	P12931 (SRC)	score1	HPRD	12540842
	Y250	Phosphorylation	O60674 (JAK2) , P12931 (SRC)	score1	HPRD	12540842
	Y310	Phosphorylation	O60674 (JAK2) , P12931 (SRC)	score1	HPRD	12540842
	Y322	Phosphorylation	P12931 (SRC)	score1	HPRD	12540842

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	Y22	Phosphorylation	P12931 (SRC)	score1	HPRD	12540842
	Y250	Phosphorylation	P12931 (SRC) , O60674 (JAK2)	score1	HPRD	12540842
	Y310	Phosphorylation	O60674 (JAK2) , P12931 (SRC)	score1	HPRD	12540842
	Y322	Phosphorylation	P12931 (SRC)	score1	HPRD	12540842

PTM-dependent PPI

	PTM type	Substrate	Site	Interactant	Association type	Source	PMID
	Phosphorylation	Q9UGK3 (STAP2)	Y250	Q14289 (PTK2B)	unknown	eFIP	28478037

PTM sites affected in variants

Site	Variant	Source	PMID	Disease [Sample source]
T191	M191	Biomuta		DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T388	M388	Biomuta		DOID:2531 / hematologic cancer [ cosmic ]