iPTMnet Report for Q9UFC0 (LRWD1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UFC0 / LRWD1_HUMAN
Protein Name Leucine-rich repeat and WD repeat-containing protein 1
Gene Name Name: LRWD1
Synonyms:CENP-33;
Organism Homo sapiens (Human)

PRO ID PR:Q9UFC0
DAG View
PRO Name leucine-rich repeat and WD repeat-containing protein 1 (human)
Definition A leucine-rich repeat and WD repeat-containing protein 1 that is encoded in the genome of human.
Short Label hLRWD1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UFC0 (LRWD1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S17 Phosphorylation HPRD   PhosphoSitePlus 20068230
S25 Phosphorylation PhosphoSitePlus
K41 Ubiquitination PhosphoSitePlus
K125 Ubiquitination PhosphoSitePlus
K151 Ubiquitination PhosphoSitePlus
K171 Ubiquitination PhosphoSitePlus
S196 Phosphorylation PhosphoSitePlus
S212 Phosphorylation HPRD   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...19664995, 19651622, 18669648, 24275569, 19690332, 20068231
K224 Ubiquitination PhosphoSitePlus
S241 Phosphorylation HPRD   PhosphoSitePlus 20068231, 18452278
S243 Phosphorylation P24941 (CDK2) HPRD   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18847512, 19664995, 18452278, 19651622, 18669648, 19690332, 20068231, 17924679
S245 Phosphorylation P24941 (CDK2) HPRD   PhosphoSitePlus 18847512, 20068231, 18452278
K246 Ubiquitination PhosphoSitePlus
S251 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 23186163, 19664994, ...15302935, 19664995, 18452278, 18669648, 19415658, 20068231
S253 Phosphorylation HPRD   PhosphoSitePlus 19413330, 18669648, 19664995
S259 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 23186163, 18220336, ...15302935, 19664995, 19415658, 18669648, 24275569, 19690332, 20068231
S264 Phosphorylation PhosphoSitePlus   UniProt 24275569
S267 Phosphorylation HPRD   PhosphoSitePlus 17525332
T328 Phosphorylation PhosphoSitePlus
Y335 Phosphorylation PhosphoSitePlus
C399 Methylation IEDB 31844290
C449 Methylation IEDB 31844290
C483 Methylation IEDB 31844290
C562 Methylation IEDB 31844290


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S251 F251 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S253 L253 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S267 N267 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
Y335 * Biomuta DOID:4159 / skin cancer [ cosmic ]